Hypothesis Bio

Studies show that people with eczema have much higher levels of a bacteria called Staphylococcus aureus on their skin, particularly during flare-ups.  Once on the skin, Staphylococcus aureus—also known as Staph, Staph aureus, or S. aureus—can secrete toxins that damage the skin barrier, increase itching, and activate the immune system. The more Staph aureus on skin, the more severe the eczema symptoms—yet standard eczema treatments like moisturizers and steroid creams do not address this underlying imbalance in the eczema skin microbiome.

At Hypothesis, we’re using biotechnology to develop clinically validated skincare that tackles the eczema microbiome head on. Our patented TPZ-01™ precision enzyme targets and kills eczema-associated Staph aureus bacteria while preserving the rest of your skin’s helpful microbiome, helping to reestablish a healthy, balanced microbiome that breaks the cycle of itching, skin barrier damage, and flare-ups.

We recommend using our Eczema Precision Hydrogel with our patented TPZ-01™ precision enzyme at least twice a day (morning and night), but more often if needed for additional soothing. Our Precision Healing Spray with TPZ-01™ is a convenient spray format designed for quick application to hard-to-reach areas or on-the-go use throughout the day. It can be used as a standalone soothing spray, or used in conjunction with our Eczema Precision Hydrogel for a double dose of the TPZ-01™ enzyme. Our Eczema Therapy Cream is a moisturizer designed to work in tandem with the TPZ-01™ enzyme, and can be used after the Precision Healing Spray or Eczema Precision Hydrogel to seal in additional moisture. Apply the Eczema Therapy Cream any time your skin needs immediate hydration or skin barrier repair.

All Hypothesis products can be applied anywhere externally on your face or body where you’re experiencing eczema symptoms, including eyelids. All of our formulas are safe for use around the eyes, dermatologist tested, and have received the National Eczema Association (NEA) Seal of Acceptance. We recommend applying liberally to itchy, irritated, or dry skin, or anywhere you typically have eczema flare-ups. 

As with all new skincare products, we recommend doing a patch test before first use, especially if you have very sensitive skin or known allergies. Apply a small amount to an area like the inside of your wrist or behind your ear, wait 24 hours, and check for any reaction before applying to larger areas or your face.

All Hypothesis products are both steroid-free and fragrance-free. We avoid known irritants in our formulas and use rigorously screened, cutting-edge ingredients with proven track records of both gentleness and efficacy. Our clinically tested formulas are dermatologist-approved, accepted by the National Eczema Association (NEA), EWG Verified™, certified Microbiome Friendly by MyMicrobiome for both infants and adults with eczema, safe for use in the delicate eye area, and hypoallergenic. 

Yes, our hypoallergenic, dermatologist-approved formulas are extensively tested by independent certifying organizations to meet the highest standards for safety and gentleness on sensitive skin. Our formulas are steroid-free and fragrance-free, have received the National Eczema Association (NEA) Seal of Acceptance, and are EWG Verified™ for meeting stringent standards for safety and sustainability. Our products are also certified Microbiome Friendly by MyMicrobiome for both infants and adults.

Yes, our formulas made with TPZ-01™ enzyme are designed to work alongside existing eczema treatments and skincare regimens, including moisturizers, steroid creams, and prescription products. All three formulations (Eczema Precision Hydrogel, Precision Healing Spray, and Eczema Therapy Cream) can be integrated into your current routine. 

When using the Eczema Precision Hydrogel, we suggest waiting 5 minutes before layering on any additional products to allow the formula to fully absorb into skin. Let our Precision Healing Spray absorb before layering on additional products. Because no other products are focused on specifically reducing Staph aureus, adding TPZ-01™ to your regimen lets you address a root cause of eczema flares that is otherwise untreated. 

While our TPZ-01™ products focus on Staph aureus, our Eczema Therapy Cream focuses on the other side of the equation—repairing and restoring the skin barrier. Our Eczema Therapy Cream is optimized to be compatible with the TPZ-01™ enzyme.