









ECZEMA THERAPY CREAM
Hydrates dry skin + restores the skin barrier
Free shipping on US orders over $50
Benefits
Dermatologist Approved
Safe for Eye Area
NEA Accepted
Hypoallergenic
EWG Verified®
Steroid Free
Certified Microbiome Friendly
Fragrance FreeIngredients
How To Use










KEY INGREDIENTS
1% Colloidal Oatmeal
This oat-derived skin protectant soothes itching and calms irritation from eczema.
3 Essential Ceramides
These bioidentical skin lipids work in tandem to help restore the skin’s natural moisture barrier.
Advanced Moisture Complex (Hyaluronic Acid, Sodium PCA, Urea, Glycerin)
Four potent moisture attractors provide immediate hydration for dry, irritated skin.
Bisabolol
The key calming component in chamomile, this anti-inflammatory ingredient helps to reduce redness.

KEY INGREDIENTS
1% Colloidal Oatmeal
This oat-derived skin protectant soothes itching and calms irritation from eczema.
3 Essential Ceramides
These bioidentical skin lipids work in tandem to help restore the skin’s natural moisture barrier.
Advanced Moisture Complex (Hyaluronic Acid, Sodium PCA, Urea, Glycerin)
Four potent moisture attractors provide immediate hydration for dry, irritated skin.
Bisabolol
The key calming component in chamomile, this anti-inflammatory ingredient helps to reduce redness



OUR INGREDIENTS
Every ingredient we use is thoughtfully chosen for its clinically proven ability to soothe irritation, strengthen the skin's protective barrier, and support a healthy microbiome balance. Our formulas deliver real results you can feel: reduced itching, lasting comfort, and resilient skin over time. All backed by rigorous research, approved by dermatologists, accepted by the National Eczema Association, EWG Verified™, and certified Microbiome Friendly by MyMicrobiome.
OUR INGREDIENTS
Every ingredient we use is thoughtfully chosen for its clinically proven ability to soothe irritation, strengthen the skin's protective barrier, and support a healthy microbiome balance. Our formulas deliver real results you can feel: reduced itching, lasting comfort, and resilient skin over time. All backed by rigorous research, approved by dermatologists, accepted by the National Eczema Association, EWG Verified®, and certified Microbiome Friendly by MyMicrobiome.
Real People, Real Results
See how our precision enzyme technology visibly calms and transforms eczema-prone skin.
I LOVE that I can use it on my child repeatedly, for as long as needed…I didn’t have to be concerned about how long she was using it, like I do with topical steroids, and the fact that IT WORKED made both of us feel better.
KIM
I knew I had a staph problem on my skin…I noticed improvements after the first couple of uses and within a few weeks the flaking is now very minimal. I’m pretty mind blown…10/10 can’t recommend this enough.
DARCI
My 6-year old has struggled with eczema since he was a baby…To say the results were incredible is an understatement. Within just a couple of weeks, his red, itchy skin completely returned to normal.
CHRISTA
I had this angry red patch on my hand for about 3 months. The doctors prescribed me antibiotics, steroid creams, etc. and nothing worked. I ordered Hypothesis as a last ditch effort and was shocked by the results…My patch was cleared up in a week and a half.
SOPHIA
I have tried everything on the market & I had lost hope. I ran into an Instagram profile of a young woman…I was her results and decided to try this brand. Initial reaction, I loved that it relieved the itching…in no time, it cleared up my flare.
HELEN
I love the texture of the product. It soothes my skin and applies very easily…can put it on right before bed or right before applying makeup. My redness and flakiness have improved and feels so much better
JESSICA
Where has this been my whole life? This formula is incredible and truly helped my eczema skin so much. It also helped me to realize that staph aureus was definitely playing a role in my flares…
BRYANA
If Hypothesis didn’t exist, I would have thrown in the towel and let urgent care shoot me up with steroids after 3.5 years of battling TSW…My skin felt immense relief after using the Eczema Therapy Cream
CHELSEA
Y’all please get this!! I’ve been having eczema flares on my hands and arm for about 3 years now and no product has worked…Hypothesis has been a game changer. I’m less flakey, not that irritated when I put on long sleeves, and minimal itching.
TAHJ
I love how smoothly it goes on and that it is easy to apply on the most sensitive of skin. The improvements in my skin were noticeable after just a few uses. I have added this as a permanent product in my eczema rotation!
BRYANA
Clinically proven to nourish dry skin + soothe irritation

96 %
said it nourished and improved dry skin*
91 %
saw improved hydration for 24 hours after a single use*
100 %
of participants saw immediate improvement in skin barrier function that lasted all day**
*Based on a 7-day clinical study of 34 adults with dry skin.
**Based on a clinical trial of 33 adults with damaged skin barriers.


FAQS
Does the Eczema Therapy Cream contain steroids or fragrance?
All Hypothesis products are both steroid-free and fragrance-free. We avoid known irritants in our formulas and use rigorously screened, cutting-edge ingredients with proven track records of both gentleness and efficacy. Our clinically tested formulas are dermatologist-approved, accepted by the National Eczema Association (NEA), EWG Verified®, certified Microbiome Friendly by MyMicrobiome for both infants and adults with eczema, safe for use in the delicate eye area, and hypoallergenic.
Where can I apply the Eczema Therapy Cream?
The Eczema Therapy Cream can be applied anywhere externally on your face or body where you’re experiencing eczema symptoms, including eyelids. As with all our products, this formula is safe for use around the eyes, dermatologist approved, and accepted by the National Eczema Association (NEA). We recommend applying liberally to itchy, irritated, or dry skin, or anywhere you typically have eczema flare-ups.
As with all new skincare products, we recommend doing a patch test before first use, especially if you have very sensitive skin or known allergies. Apply a small amount to an area like the inside of your wrist or behind your ear, wait 24 hours, and check for any reaction before applying to larger areas or your face.
How do I use Hypothesis products in my daily routine?
Our Eczema Therapy Cream is a moisturizer designed to work in tandem with our patented TPZ-01™ enzyme, and can be used after the Precision Healing Spray or Eczema Precision Hydrogel to seal in additional moisture. Apply the Eczema Therapy Cream any time your skin needs immediate hydration or skin barrier repair. We recommend using our Eczema Precision Hydrogel with the TPZ-01™ precision enzyme at least twice a day (morning and night), but more often if needed for additional soothing. Our Precision Healing Spray with TPZ-01™ is a convenient spray format designed for quick application to hard-to-reach areas or on-the-go use throughout the day. It can be used as a standalone soothing spray, or used in conjunction with our Eczema Precision Hydrogel for a double dose of the TPZ-01™ enzyme.
How long does it take to see results?
In clinical studies, the Eczema Therapy Cream immediately hydrates and strengthens the skin barrier with benefits that last all day.
Is the Eczema Therapy Cream safe for babies and children?
Yes, all of our hypoallergenic, dermatologist-approved formulas are extensively tested by independent certifying organizations to meet the highest standards for safety and gentleness on sensitive skin. Our formulas are steroid-free and fragrance-free, have received the National Eczema Association (NEA) Seal of Acceptance, and are EWG Verified® for meeting stringent standards for safety and sustainability. Our products are also certified Microbiome Friendly by MyMicrobiome for both infants and adults.
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Clinically tested, next-generation formulas that treat the bacteria behind flare-ups to visibly transform skin.





