Our Mission
To radically transform the way we treat skin conditions by unlocking the microbiome’s potential. We anchor our solutions in rigorous scientific research and clinical validation to provide lasting, real relief.
Pioneers in Microbiome Science
Hypothesis was founded by four scientists who have spent decades researching microbiomes—the complex, interwoven microbial communities that exist throughout the natural world, including on our own skin.
Our research on repairing the skin microbiome through enzyme technology is funded by the National Institutes of Health (NIH) and is peer-reviewed by experts in the field.
THE BREAKTHROUGH
Our proprietary enzyme
To fill this gap in eczema care, we created the patented TPZ-01™ enzyme, which addresses the skin’s microbiome imbalances head on.
Our enzyme’s superpower is precision: it targets and kills eczema-associated Staph aureus bacteria, leaving beneficial microbes so the microbiome is restored to a healthy, balanced state.
THE BREAKTHROUGH
Our proprietary enzyme
To fill this gap in eczema care, we created the patented TPZ-01™ enzyme, which addresses the skin’s microbiome imbalances head on.
Our enzyme’s superpower is precision: it targets and kills eczema-associated Staph aureus bacteria, leaving beneficial microbes so the microbiome is restored to a healthy, balanced state.
The JOURNEY
Rethinking Conventional Eczema Treatments
Over the past 15 years, scientists have uncovered the central role that Staph aureus and the skin microbiome play in eczema. But eczema treatments still use the same ingredients we’ve had for decades—ones that either ignore the underlying microbiome imbalances that drive eczema, or damage the entire microbiome, including all beneficial microorganisms.
This is where we knew we could make a difference.
The JOURNEY
Rethinking Conventional Eczema Treatments
Over the past 15 years, scientists have uncovered the central role that Staph aureus and the skin microbiome play in eczema. But eczema treatments still use the same ingredients we’ve had for decades—ones that either ignore the underlying microbiome imbalances that drive eczema, or damage the entire microbiome, including all beneficial microorganisms.
This is where we knew we could make a difference.
Purposeful ingredients with real results
We believe in results-driven ingredients that minimize environmental impact, and our streamlined formulas are safe, multifunctional, and simple to use. Above all, every ingredient has a purpose: Our formulas include nothing more and nothing less than what is needed to provide meaningful eczema relief and support a healthy microbiome.