Our Mission
To radically transform the way we treat skin conditions by unlocking the microbiome’s potential. We anchor our solutions in rigorous scientific research and clinical validation to provide lasting, real relief.
Pioneers in Microbiome Science
Hypothesis was founded by four scientists who have spent decades researching microbiomes—the complex, interwoven microbial communities that exist throughout the natural world, including on our own skin.
Our research on repairing the skin microbiome through enzyme technology is funded by the National Institutes of Health (NIH) and is peer-reviewed by experts in the field.
THE BREAKTHROUGH
Precision Enzyme Technology
To address this gap in skincare, we developed our proprietary technology: enzymes that target specific harmful bacteria while preserving beneficial microbes.
Our TPZ-01™ enzyme targets Staph aureus, the bacteria behind up to 90% of eczema flares.
Our CUT-02™ enzyme targets C. acnes, the bacteria driving acne breakouts.
Both enzymes share the same superpower: precision. They eliminate only the harmful bacteria on skin, leaving the good bacteria intact so the microbiome can return to a healthy, balanced state.
THE BREAKTHROUGH
Precision Enzyme Technology
To address this gap in skincare, we developed our proprietary technology: enzymes that target specific harmful bacteria while preserving beneficial microbes.
Our TPZ-01™ enzyme targets Staph aureus, the bacteria behind up to 90% of eczema flares.
Our CUT-02™ enzyme targets C. acnes, the bacteria driving acne breakouts.
Both enzymes share the same superpower: precision. They eliminate only the harmful bacteria on skin, leaving the good bacteria intact so the microbiome can return to a healthy, balanced state.
The JOURNEY
Rethinking Conventional Eczema Treatments
We started by questioning conventional approaches to skin conditions.
Scientists have uncovered the central role of skin microbiome imbalances in conditions like eczema and acne, but most treatments still rely on the same all-or-nothing approaches that have been used for decades. Some treatments address only symptoms and ignore bacterial imbalances entirely, while others wipe out all bacteria, good and bad, leaving the entire microbiome damaged and vulnerable.
This is where we knew we could make a difference.
The JOURNEY
Rethinking Conventional Skincare Treatments
We started by questioning conventional approaches to skin conditions.
Scientists have uncovered the central role of skin microbiome imbalances in conditions like eczema and acne, but most treatments still rely on the same all-or-nothing approaches that have been used for decades. Some treatments address only symptoms and ignore bacterial imbalances entirely, while others wipe out all bacteria, good and bad, leaving the entire microbiome damaged and vulnerable.
This is where we knew we could make a difference.
Purposeful ingredients with real results
We believe in results-driven ingredients that minimize environmental impact, and our streamlined formulas are safe, multifunctional, and simple to use. Above all, every ingredient has a purpose: Our formulas include nothing more and nothing less than what is needed to restore skin health and a balanced microbiome.