OUR INGREDIENTS
Our in-house lab is the heart of our scientists' work, where each ingredient—including our patented TPZ-01™and CUT-02™ enzymes—is meticulously selected for clinically proven efficacy, purity, and safety.
The Science of Subtractions
When it comes to sensitive, reactive skin, what isn’t in our formulas matters just as much as what is.
Fragrance Free
Steroid Free
Phthalate Free
Propylene Glycol Free
No Dyes
Cruelty Free
Alcohol Free
Our Key Ingredients
Results-driven, rigorously researched, and approved by dermatologists.
TPZ-01™ ENZYME
Produced via fermentation, our proprietary patented TPZ-01™ enzyme specifically targets Staph aureus microbiome imbalances in eczema-prone skin.
CUT-02™ Enzyme
A patented first-of-its-kind precision enzyme that selectively targets acne-causing C. acnes bacteria while preserving the skin’s beneficial microbiome.
Salicylic Acid
An FDA-approved acne-fighting ingredient that gently exfoliates inside the pore to dissolve excess oil and dead skin cells, helping to clear breakouts and prevent new ones from forming.
COLLOIDAL OATMEAL
An FDA-approved anti-inflammatory skin protectant that relieves the itchiness and redness of eczema.
Allantoin
An FDA-approved multifunctional skin protectant known for soothing irritation and softening skin.
Essential Ceramide Complex
Three bio-identical skin lipids that boost hydration levels and soften flaky, dry skin.
Advanced Moisture Complex
Hyaluronic acid, glycerin, urea, sodium PCA, and trehalose work synergistically to draw moisture deep into skin.
Used In
Hyaluronic acid, glycerin, urea, sodium PCA, and trehalose work synergistically to draw moisture deep into skin.
Hyaluronic acid, glycerin, urea, sodium PCA, and trehalose work synergistically to draw moisture deep into skin.
Hyaluronic acid, glycerin, urea, sodium PCA, and trehalose work synergistically to draw moisture deep into skin.
Allantoin
An FDA-approved multifunctional skin protectant known for soothing irritation and softening skin.
Used In
An FDA-approved multifunctional skin protectant known for soothing irritation and softening skin.
An FDA-approved multifunctional skin protectant known for soothing irritation and softening skin.
An FDA-approved multifunctional skin protectant known for soothing irritation and softening skin.
Aloe
The anti-inflammatory extract from the aloe plant helps soothe irritated skin and reduce visible redness.
Used In
The anti-inflammatory extract from the aloe plant helps soothe irritated skin and reduce visible redness.
The anti-inflammatory extract from the aloe plant helps soothe irritated skin and reduce visible redness.
The anti-inflammatory extract from the aloe plant helps soothe irritated skin and reduce visible redness.
Amino Acids
Amino acids like L-Arginine HCl, L-Methionine, and N-Acetyl-L-Cysteine (NAC) are essential building blocks that moisturize and help support antioxidant protection to replenish the skin barrier.
Amino acids like L-Arginine HCl, L-Methionine, and N-Acetyl-L-Cysteine (NAC) are essential building blocks that moisturize and help support antioxidant protection to replenish the skin barrier.
Amino acids like L-Arginine HCl, L-Methionine, and N-Acetyl-L-Cysteine (NAC) are essential building blocks that moisturize and help support antioxidant protection to replenish the skin barrier.
Amino acids like L-Arginine HCl, L-Methionine, and N-Acetyl-L-Cysteine (NAC) are essential building blocks that moisturize and help support antioxidant protection to replenish the skin barrier.
Betaine
A potent humectant that attracts moisture and protects against environmental stressors to skin.
Used In
A potent humectant that attracts moisture and protects against environmental stressors to skin.
A potent humectant that attracts moisture and protects against environmental stressors to skin.
A potent humectant that attracts moisture and protects against environmental stressors to skin.
Bisabolol + Ginger Extract
A synergistic blend of two anti-inflammatory plant extracts that help to reduce redness in skin and minimize flare-ups.
Used In
A synergistic blend of two anti-inflammatory plant extracts that help to reduce redness in skin and minimize flare-ups.
A synergistic blend of two anti-inflammatory plant extracts that help to reduce redness in skin and minimize flare-ups.
A synergistic blend of two anti-inflammatory plant extracts that help to reduce redness in skin and minimize flare-ups.
Centella Asiatica Extract
Rich in antioxidants, centella helps to calm irritation and strengthen the skin’s naturally protective barrier.
Rich in antioxidants, centella helps to calm irritation and strengthen the skin’s naturally protective barrier.
Rich in antioxidants, centella helps to calm irritation and strengthen the skin’s naturally protective barrier.
Rich in antioxidants, centella helps to calm irritation and strengthen the skin’s naturally protective barrier.
Colloidal Oatmeal
An FDA-approved anti-inflammatory skin protectant that relieves the itchiness and redness of eczema.
An FDA-approved anti-inflammatory skin protectant that relieves the itchiness and redness of eczema.
An FDA-approved anti-inflammatory skin protectant that relieves the itchiness and redness of eczema.
An FDA-approved anti-inflammatory skin protectant that relieves the itchiness and redness of eczema.
CUT-02™ Enzyme
A patented first-of-its-kind precision enzyme that selectively targets acne-causing C. acnes bacteria while preserving the skin’s beneficial microbiome.
A patented first-of-its-kind precision enzyme that selectively targets acne-causing C. acnes bacteria while preserving the skin’s beneficial microbiome.
A patented first-of-its-kind precision enzyme that selectively targets acne-causing C. acnes bacteria while preserving the skin’s beneficial microbiome.
A patented first-of-its-kind precision enzyme that selectively targets acne-causing C. acnes bacteria while preserving the skin’s beneficial microbiome.
Essential Ceramide Complex
Three bio-identical skin lipids that boost hydration levels and soften flaky, dry skin.
Used In
Three bio-identical skin lipids that boost hydration levels and soften flaky, dry skin.
Three bio-identical skin lipids that boost hydration levels and soften flaky, dry skin.
Three bio-identical skin lipids that boost hydration levels and soften flaky, dry skin.
Glycolic Acid
A powerful but gentle alpha hydroxy acid that exfoliates and helps to even skin tone and fade discoloration from acne.
Used In
A powerful but gentle alpha hydroxy acid that exfoliates and helps to even skin tone and fade discoloration from acne.
A powerful but gentle alpha hydroxy acid that exfoliates and helps to even skin tone and fade discoloration from acne.
A powerful but gentle alpha hydroxy acid that exfoliates and helps to even skin tone and fade discoloration from acne.
Jojoba Esters
A jojoba oil-derived emollient that mimics wax esters found on the skin, working seamlessly with skin’s natural oils to improve moisturization, address itchiness, and combat dry, rough skin.
Used In
A jojoba oil-derived emollient that mimics wax esters found on the skin, working seamlessly with skin’s natural oils to improve moisturization, address itchiness, and combat dry, rough skin.
A jojoba oil-derived emollient that mimics wax esters found on the skin, working seamlessly with skin’s natural oils to improve moisturization, address itchiness, and combat dry, rough skin.
A jojoba oil-derived emollient that mimics wax esters found on the skin, working seamlessly with skin’s natural oils to improve moisturization, address itchiness, and combat dry, rough skin.
Pro-Vitamin B5
A moisture magnet ingredient that boosts hydration and helps maintain skin integrity by improving its protective barrier function.
A moisture magnet ingredient that boosts hydration and helps maintain skin integrity by improving its protective barrier function.
A moisture magnet ingredient that boosts hydration and helps maintain skin integrity by improving its protective barrier function.
A moisture magnet ingredient that boosts hydration and helps maintain skin integrity by improving its protective barrier function.
Salicylic Acid
An FDA-approved acne-fighting ingredient that gently exfoliates inside the pore to dissolve excess oil and dead skin cells, helping to clear breakouts and prevent new ones from forming.
An FDA-approved acne-fighting ingredient that gently exfoliates inside the pore to dissolve excess oil and dead skin cells, helping to clear breakouts and prevent new ones from forming.
An FDA-approved acne-fighting ingredient that gently exfoliates inside the pore to dissolve excess oil and dead skin cells, helping to clear breakouts and prevent new ones from forming.
An FDA-approved acne-fighting ingredient that gently exfoliates inside the pore to dissolve excess oil and dead skin cells, helping to clear breakouts and prevent new ones from forming.
Shea Butter
A plant-derived ingredient rich in essential fatty acids that deeply moisturizes and fortifies the skin barrier.
Used In
A plant-derived ingredient rich in essential fatty acids that deeply moisturizes and fortifies the skin barrier.
A plant-derived ingredient rich in essential fatty acids that deeply moisturizes and fortifies the skin barrier.
A plant-derived ingredient rich in essential fatty acids that deeply moisturizes and fortifies the skin barrier.
Sorbitol
A non-irritating, naturally occurring compound found in fruits that attracts moisture to maintain a healthy skin barrier.
A non-irritating, naturally occurring compound found in fruits that attracts moisture to maintain a healthy skin barrier.
A non-irritating, naturally occurring compound found in fruits that attracts moisture to maintain a healthy skin barrier.
A non-irritating, naturally occurring compound found in fruits that attracts moisture to maintain a healthy skin barrier.
Tea Tree Oil
Derived from the tea tree plant, this ingredient features antioxidant, antibacterial, and anti-inflammatory properties to purify and help calm inflamed skin.
Used In
Derived from the tea tree plant, this ingredient features antioxidant, antibacterial, and anti-inflammatory properties to purify and help calm inflamed skin.
Derived from the tea tree plant, this ingredient features antioxidant, antibacterial, and anti-inflammatory properties to purify and help calm inflamed skin.
Derived from the tea tree plant, this ingredient features antioxidant, antibacterial, and anti-inflammatory properties to purify and help calm inflamed skin.
TPZ-01™ Enzyme
Produced via fermentation, our proprietary patented TPZ-01™ enzyme specifically targets Staph aureus microbiome imbalances in eczema-prone skin.
Produced via fermentation, our proprietary patented TPZ-01™ enzyme specifically targets Staph aureus microbiome imbalances in eczema-prone skin.
Produced via fermentation, our proprietary patented TPZ-01™ enzyme specifically targets Staph aureus microbiome imbalances in eczema-prone skin.
Produced via fermentation, our proprietary patented TPZ-01™ enzyme specifically targets Staph aureus microbiome imbalances in eczema-prone skin.
WATER
High-purity deionized water processed through carbon filtration, mixed-bed deionizers, UV disinfection, and final sterile filtration—and rigorously tested for pH and microbiological purity.
High-purity deionized water processed through carbon filtration, mixed-bed deionizers, UV disinfection, and final sterile filtration—and rigorously tested for pH and microbiological purity.
High-purity deionized water processed through carbon filtration, mixed-bed deionizers, UV disinfection, and final sterile filtration—and rigorously tested for pH and microbiological purity.
High-purity deionized water processed through carbon filtration, mixed-bed deionizers, UV disinfection, and final sterile filtration—and rigorously tested for pH and microbiological purity.
Zinc
This anti-inflammatory mineral helps lower sebum production and can help inhibit the growth of C. acnes bacteria.
Used In
This anti-inflammatory mineral helps lower sebum production and can help inhibit the growth of C. acnes bacteria.
This anti-inflammatory mineral helps lower sebum production and can help inhibit the growth of C. acnes bacteria.
This anti-inflammatory mineral helps lower sebum production and can help inhibit the growth of C. acnes bacteria.
Science-First Formulas
Every hypothesis™ formula is carefully calibrated to deliver real, meaningful results and restore the microbiome. We use high-purity deionized water as the foundation of every product—purified through multiple filtration systems and tested to ensure it's clean and safe. We don’t stop there: All our formulas for both acne and eczema have been rigorously validated in clinical studies to prove they’re effective, stable, and gentle on skin.