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Precision Healing Spray
4.4
Rated 4.4 out of 5 stars
4.4
#size_standard size 200ml
4.6
Rated 4.6 out of 5 stars
4.6
#size_standard size 80ml
4.3
Rated 4.3 out of 5 stars
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Eczema Precision Kit
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$59.99 $69.98

Eczema Relief + Repair Duo

4.4
Rated 4.4 out of 5 stars
4.4

This essential eczema care duo addresses eczema flare-ups at their source, with our patented TPZ-01™ enzyme that targets and kills Staph aureus bacteria while restoring your skin's natural balance. Our Eczema Precision Hydrogel delivers lasting relief and balances the microbiome, while our Eczema Therapy Cream replenishes your skin barrier and locks in moisture. Together, they soothe itching and reduce irritation for real relief.

2-piece Eczema Relief + Repair Duo includes:
Eczema Precision Hydrogel 80 mL (temporarily 2 x Travel Size Hydrogel 30 mL)
Eczema Therapy Cream 200 mL

Currently available

Relief + Repair bundles with 2 travel-size Hydrogels at a special price. Full-size version coming back soon.

Benefits

Eczema Precision Hydrogel

  • Targets and kills eczema-causing Staph aureus bacteria
  • Relieves itching, redness, and irritation from eczema
  • Preserves the skin’s beneficial microbiome

Eczema Therapy Cream

  • Repairs and strengthens the skin barrier
  • Provides all-day hydration and relief for dry skin
  • Relieves itching and irritation from eczema
Dermatologist Approved
NEA Accepted
EWG Verified®
Safe for Eye Area
Certified Microbiome Friendly
Hypoallergenic
Fragrance Free
Steroid Free
Ingredients

TPZ-01™ Enzyme 
Our patented TPZ-01™ enzyme selectively targets and kills 99.99% of eczema-associated Staph aureus bacteria within 5 minutes while preserving beneficial microorganisms.

Colloidal Oatmeal 
This oat-derived skin protectant soothes itching and calms irritation from eczema.

3 Essential Ceramides
These bioidentical skin lipids work in tandem to help restore the skin’s natural moisture barrier.

Advanced Moisture Complex (Hyaluronic Acid, Sodium PCA, Urea, Glycerin)
Four potent moisture attractors provide immediate hydration for dry, irritated skin.

Full Ingredient List

Eczema Precision Hydrogel
Active Ingredient: 0.01% Colloidal Oatmeal
Inactive Ingredients:
Water/Aqua/Eau, Sorbitol, Arginine HCl, Hydroxyethylpiperazine Ethane Sulfonic Acid, Panthenol, Sodium Chloride, Hydroxypropyl Methylcellulose, Methionine, Calcium Chloride, Methylparaben, Sodium Hydroxide, Acetyl Cysteine, sr-(Staphylococcus sp. Polypeptide-1 Dipeptide-81 Streptococcus Suis Phage Polypeptide-1 Dipeptide-19 Hexapeptide-40), Hydrochloric Acid

Eczema Therapy Cream
Active Ingredient: 1% Colloidal Oatmeal
Inactive Ingredients:
Water/Aqua/Eau, Glycerin, Caprylic/Capric Triglyceride, Cetyl Alcohol, Bis-Diglyceryl Polyacyladipate-2, Jojoba Esters, Polyglyceryl-2 Stearate, Butyrospermum Parkii (Shea) Butter, Bisabolol, Zingiber Officinale (Ginger) Extract, Ceramide NP, Ceramide AP, Ceramide EOP, Phytosphingosine, Cholesterol, Sodium PCA, Urea, Trehalose, Sodium Hyaluronate, Hexylene Glycol, Polyquaternium-51, Triacetin, Caprylyl Glycol, Sodium Lauroyl Lactylate, Tocopherol, Tocopheryl Acetate, Dimethicone, Ammonium Acryloyldimethyltaurate/VP Copolymer, Hydroxyacetophenone, Glyceryl Stearate, Stearyl Alcohol, Carbomer, Xanthan Gum, 1,2-Hexanediol, Citric Acid, Sodium Hydroxide, Tetrasodium Glutamate Diacetate, Ethylhexylglycerin

How To Use

Shake and apply Eczema Precision Hydrogel to eczema-prone skin at least twice daily (morning and evening) or as often as desired. Let absorb into the skin for 5 minutes before layering on other skincare. Use as a standalone treatment, or follow with Eczema Therapy Cream as part of a comprehensive eczema regimen. Apply Eczema Therapy Cream to body and face as often as needed to lock in moisture, soothe itch, and calm dry, eczema-prone skin.

ECZEMA THERAPY CREAM

This deeply hydrating moisturizer is designed to work in parallel with the Eczema Precision Hydrogel to repair the skin barrier. Made with 1% colloidal oatmeal and ceramides, this pH-balanced formula relieves the itch of eczema and supports an optimal pH level for a healthy microbiome.

ECZEMA PRECISION HYDROGEL

Made with our patented TPZ-01™ enzyme, this lightweight hydrogel is the first eczema treatment to address the skin’s microbiome imbalance head on, targeting and killing eczema-associated Staph aureus bacteria to break the cycle of damage and irritation so skin can finally heal.

ECZEMA THERAPY CREAM

This deeply hydrating moisturizer is designed to work in parallel with the Eczema Precision Hydrogel to repair the skin barrier. Made with 1% colloidal oatmeal and ceramides, this pH-balanced formula relieves the itch of eczema and supports an optimal pH level for a healthy microbiome.

ECZEMA PRECISION HYDROGEL

Made with our patented TPZ-01™ enzyme, this lightweight hydrogel is the first eczema treatment to address the skin’s microbiome imbalance head on, targeting and killing eczema-associated Staph aureus bacteria to break the cycle of damage and irritation so skin can finally heal.

Real People, Real Results

I LOVE that I can use it on my child repeatedly, for as long as needed…I didn’t have to be concerned about how long she was using it, like I do with topical steroids, and the fact that IT WORKED made both of us feel better.

KIM

I knew I had a staph problem on my skin…I noticed improvements after the first couple of uses and within a few weeks the flaking is now very minimal.  I’m pretty mind blown…10/10 can’t recommend this enough.

DARCI

My 6-year old has struggled with eczema since he was a baby…To say the results were incredible is an understatement.  Within just a couple of weeks, his red, itchy skin completely returned to normal.

CHRISTA

I had this angry red patch on my hand for about 3 months.  The doctors prescribed me antibiotics, steroid creams, etc. and nothing worked.  I ordered Hypothesis as a last ditch effort and was shocked by the results…My patch was cleared up in a week and a half.

SOPHIA

I have tried everything on the market & I had lost hope.  I ran into an Instagram profile of a young woman…I was her results and decided to try this brand.  Initial reaction, I loved that it relieved the itching…in no time, it cleared up my flare.

HELEN

Within 1 to 2 days my inflammation is way down, and in less than a week it is almost gone…It really has worked better than anything that I have tried.

ERIN

I love the texture of the product.  It soothes my skin and applies very easily…can put it on right before bed or right before applying makeup.  My redness and flakiness have improved and feels so much better

JESSICA

Where has this been my whole life? This formula is incredible and truly helped my eczema skin so much. It also helped me to realize that staph aureus was definitely playing a role in my flares…

BRYANA

If Hypothesis didn’t exist, I would have thrown in the towel and let urgent care shoot me up with steroids after 3.5 years of battling TSW…My skin felt immense relief after using the Eczema Therapy Cream

CHELSEA

Y’all please get this!!  I’ve been having eczema flares on my hands and arm for about 3 years now and no product has worked…Hypothesis has been a game changer.  I’m less flakey, not that irritated when I put on long sleeves, and minimal itching.

TAHJ

It definitely has been a god send to finally have something that helps me to manage my eczema.

JANE

I love how smoothly it goes on and that it is easy to apply on the most sensitive of skin. The improvements in my skin were noticeable after just a few uses. I have added this as a permanent product in my eczema rotation!

BRYANA

Eczema Precision Hydrogel

Relieves irritation + itching from eczema

RESULTS

2.5x

more effective than a standard eczema treatment*

85%

reduction in eczema-associated Staph aureus bacteria on the skin*

100%

of participants saw reduced eczema symptoms within 2 weeks*

*Based on a 2-week clinical trial of 24 adults with moderate to severe eczema comparing Hypothesis Eczema Precision Hydrogel to a product containing over-the-counter levels of colloidal oatmeal.

Eczema Therapy Cream

Hydrates dry skin + restores the skin barrier

RESULTS

96%

said it nourished and improved dry skin*

91%

saw improved hydration for 24 hours after a single use*

100%

of participants saw immediate improvement in skin barrier function that lasted all day**

*Based on a 7-day clinical study of 34 adults with dry skin.
**Based on a clinical trial of 33 adults with damaged skin barriers.

Smart Science, By Design

COLLOIDAL
OATMEAL
BLEACH
BATHS
STEROID
CREAMS
PRESCRIPTION
DRUGS
Treats eczema symptoms
Targets eczema-associated S. aureus
Preserves the skin’s beneficial microbiome
Patented technology
No side effects
*data on file

FAQS

How is this different from other eczema treatments?

​​Studies show that people with eczema have much higher levels of a bacteria called Staphylococcus aureus on their skin, particularly during flare-ups.  Once on the skin, Staphylococcus aureus—also known as Staph, Staph aureus, or S. aureus—can secrete toxins that damage the skin barrier, increase itching, and activate the immune system. The more Staph aureus on skin, the more severe the eczema symptoms—yet standard eczema treatments like moisturizers and steroid creams do not address this underlying imbalance in the eczema skin microbiome.

At Hypothesis, we’re using biotechnology to develop clinically validated skincare that tackles the eczema microbiome head on. Our patented TPZ-01™ precision enzyme targets and kills eczema-associated Staph aureus bacteria while preserving the rest of your skin’s helpful microbiome, helping to reestablish a healthy, balanced microbiome that breaks the cycle of itching, skin barrier damage, and flare-ups.

Do Hypothesis products contain steroids or fragrance?

All Hypothesis products are both steroid-free and fragrance-free. We avoid known irritants in our formulas and use rigorously screened, cutting-edge ingredients with proven track records of both gentleness and efficacy. Our clinically tested formulas are dermatologist-approved, accepted by the National Eczema Association (NEA), EWG Verified™, certified Microbiome Friendly by MyMicrobiome for both infants and adults with eczema, safe for use in the delicate eye area, and hypoallergenic.

Where can I apply Hypothesis products?

The Eczema Precision Hydrogel and Eczema Therapy Cream can be applied anywhere externally on your face or body where you’re experiencing eczema symptoms, including eyelids. As with all our products, these formulas are safe for use around the eyes, dermatologist approved, and accepted by the National Eczema Association (NEA). We recommend applying liberally to itchy, irritated, or dry skin, or anywhere you typically have eczema flare-ups.

How do I use Hypothesis products in my daily routine?

We recommend using our Eczema Precision Hydrogel with our patented TPZ-01™ precision enzyme at least twice a day (morning and night), but more often if needed for additional soothing. Our Precision Healing Spray with TPZ-01™ is a convenient spray format designed for quick application to hard-to-reach areas or on-the-go use throughout the day. It can be used as a standalone soothing spray, or used in conjunction with our Eczema Precision Hydrogel for a double dose of the TPZ-01™ enzyme. Our Eczema Therapy Cream is a moisturizer designed to work in tandem with the TPZ-01™ enzyme, and can be used after the Precision Healing Spray or Eczema Precision Hydrogel to seal in additional moisture. Apply the Eczema Therapy Cream any time your skin needs immediate hydration or skin barrier repair.

How long does it take to see results?

In clinical studies of the Eczema Precision Hydrogel, most users saw initial improvement in their eczema symptoms within a week, with best results after 2–4 weeks of twice-daily use and an 85% reduction in eczema-associated Staph aureus bacteria on the skin. In clinical studies, the Eczema Therapy Cream immediately hydrates and strengthens the skin barrier with benefits that last all day.

Reviews

86%would recommend these products
4.4
Rated 4.4 out of 5 stars
Based on 159 reviews
Reviews Summary
Customers say this eczema skincare line delivers noticeable relief for many users, with the hydrogel praised for its lightweight texture, quick absorption, and cooling sensation that reduces itching and redness. The therapy cream is frequently described as lightweight, non-greasy, and hydrating, with smooth application and fast absorption. Common feedback highlights significant improvement in flare-ups and calmer skin within days to weeks. Many users appreciate the gentle formula that doesn't irritate sensitive skin or cause stinging. Some note the products have a distinctive smell and may require reapplication or layering for optimal hydration. A few users report minimal results or dryness with initial use.
159 reviews
  • J
    Jennifer
    Verified Buyer
    Reviewing
    Eczema Precision Hydrogel
    I recommend this product
    What are your skin challenges? Eczema, Redness, Itchiness, Texture, Dryness
    What is your primary area of concern? Face
    What did you like about the product? Visible results, Redness reduction, Barrier repair, Everyday use, Fast absorbing
    Rated 5 out of 5 stars
    7 months ago
    Infant Eczema Success

    My now 5 month old has been dealing with eczema since he was just a month old which mainly affects the cheeks of his face- causing them to be "weepy" and red. I've tried so many things (probiotics, hypochlorous spray, Manuka honey, Dead Sea salt baths.... you name it and I most likely tried it). My biggest promise was to avoid steroids and I'm glad I didn't give in. Within two weeks of consistent use this is the best his skin has looked since coming home from the hospital. I am overjoyed and grateful for this product. It's a staple in his skincare routine!

  • SN
    Sophia N.
    Verified Buyer
    Reviewing
    Eczema Precision Hydrogel
    I recommend this product
    What are your skin challenges? Eczema, Dryness, Itchiness, Texture, Redness
    What is your primary area of concern? Hands, Trunk, Legs, Arms
    What did you like about the product? Visible results, Soothing relief, Itch relief, Barrier repair, Everyday use
    Rated 5 out of 5 stars
    10 months ago
    Magic in a Bottle!

    I had this angry red patch on my hand for about 3 months. The doctors prescribed me antibiotics, steroid creams, etc. and nothing worked. I developed these patches all over my body, and the doctors kept insisting that steroid creams were the best/only way to heal my eczema. I ordered Hypothesis immediately as a last ditch effort and was shocked by the results. After using the gel, spray, and cream on my hand, my patch was cleared up in a week and a half. The spot is almost completely gone and my skin is so close to feeling like it used to. After using my hand as a test patch and having no reaction, I’ve started using this all over my body and am still amazed by the results! Couldn’t recommend this more. (Before and After Pictures for Proof!!)

  • DW
    Darci W.
    Reviewing
    Eczema Precision Hydrogel
    I recommend this product
    What are your skin challenges? Eczema, Redness, Itchiness, Skin thickening, Dryness
    What is your primary area of concern? Face, Hands, Legs, Arms
    What did you like about the product? Visible results, Soothing relief, Itch relief, Redness reduction
    Rated 5 out of 5 stars
    12 months ago
    It worked.

    I started using this product mid flare on my face, I know I had a staph problem on my skin because I had previously had a skin scraping from my dermatologist to confirm it was staph. After a round of antibiotics I was still having issues with the bacteria causing another flare. I had redness, a burning sensation when applying cream, pretty intense flaking with an all over puffiness/swollen complexion. I noticed improvements after the first couple of uses and within a few weeks the flaking is now very minimal, I have no more redness or burning and as a by product my skin is less puffy. I'm pretty mind blown. Make sure you wait the 5 minutes before applying any other creams after - which is the only annoying part of using this product but I really can't get over how well this worked on my skin. I will be using this as a regular part of my routine. 10/10 can't recommend this enough.

  • AE
    Ariane E.
    Reviewing
    Eczema Therapy Cream
    I recommend this product
    What are your skin challenges? Eczema, Itchiness, Dryness
    What is your primary area of concern? Face, Legs, Trunk
    What did you like about the product? Hydrating, Everyday use, Gentle formula, Fast absorbing
    Rated 5 out of 5 stars
    1 year ago
    Gentle enough for toddler skin!

    We loved the cream for everything. I found that I needed less of the product over time as the dryness improved immediately and a little went a long way to keeping the skin hydrated.

  • AD
    Alexia D.
    Reviewing
    Eczema Therapy Cream
    I recommend this product
    What are your skin challenges? Eczema, Redness, Itchiness, Dryness
    What is your primary area of concern? Face
    What did you like about the product? Hydrating, Everyday use, Gentle formula, Fast absorbing, Versatile
    Rated 5 out of 5 stars
    1 year ago
    Deeply hydrating everyday lotion for dry skin

    I've been very impressed with the eczema therapy cream. As a person with dry, sensitive skin, I've had a lot of negative reactions to lotions -- even those that are listed as "sensitive" or "hypoallergenic". With this one, I didn't have any of that sensitivity or irritation pop up. Instead, it felt like a light, soothing lotion with a surprisingly deep and long-lasting hydrating effect. I also appreciate the lack of perfume in this, since that can also be a trigger for my skin to react. The eczema therapy cream has a mild oatmeal scent that is pleasant and not distracting. I'm looking forward to using this with our family's dry hands in the winter!