Fight Acne. Not Your Skin.
Finally, smarter acne care without the dryness, redness, and irritation.
Powered by CUT-02™, our patented precision enzyme that selectively targets acne bacteria without the collateral damage.
Try the 3-Step Precision Acne Routine risk-free with our 60-day money-back guarantee.
Rethink the Pimple Patch
Typical patches sit on the surface. Our microdarts go deeper, delivering CUT-02™ beneath the skin to stop early-stage pimples before they form.
A Smarter Spray for Clear Skin
Hypochlorous acid sprays kill all bacteria, good and bad. CUT-02™ targets only the bacteria driving your breakouts—without disrupting your microbiome.
Fight acne. Not your skin.
Finally, a smarter acne routine without the dryness, redness, and irritation.
Powered by CUT-02™, our patented precision enzyme that selectively targets acne bacteria without the collateral damage.
Try the 3-Step Precision Acne Routine risk-free with our 60-day money-back guarantee.
Dermatologist Approved
Designed for Sensitive Skin
No benzoyl peroxide
Non-comedogenic
Acne Care Reimagined. Powered by CUT-02™.
YOUR DAILY ROUTINE
Use morning and night to treat and prevent acne.
WHEN SKIN NEEDS IT
Apply anytime to restore skin to its balanced state.
YOUR DAILY ROUTINE
Use morning and night to treat and prevent acne.
WHEN SKIN NEEDS IT
Apply anytime to restore skin to its balanced state.
Your Skin. Your Stories.
#SKINWARRIORSSHOP ACNE CARE BUNDLES
The precision care and advanced bacteria control that acne-prone skin needs.
DAILY REGIMEN
3-STEP PRECISION ACNE ROUTINE
Your three essentials for everyday acne prevention: gentle cleansing, precision bacteria control + weightless moisture.
COMPLETE CARE
Complete Acne Care Set
Everything acne-prone skin needs, from daily prevention to on-the-go soothing and early-stage pimple control.
SPOT TREAT
Precision Patch 3-Pack
3 packs of our microdart blemish patches to deliver bacteria-targeting CUT-02™ deep into early-stage pimples.
CLEANSE + TREAT
Acne Essentials Duo
Our simple two-step routine to unclog pores, cleanse skin, and target acne bacteria at the source.
Real People, Real Results
I loved these products for treating my acne. I think I’ve improved by about 70–80%, which has pleasantly surprised me since I had tried several products before and none of them worked for me!! ✨
JULIETH
One use actually lowered my inflammation and irritation! I feel like overnight the microdarts helped to lower the overall redness and appearance, and they stayed on pretty well. I did not feel them while I was sleeping, and they were easy to apply as well as take off. Would recommend!
HAILEY
I've been struggling with acne for a really long time, so I'm always careful with trying new skincare. But I honestly loved these products. My inflamed breakouts disappeared and I didn't really get new ones during that time. Overall, my skin looks calmer and healthier now.
MARYNA
I can't believe how much these blemish patches reduced the irritation, redness and even pain of my acne. I get hormonal acne during that time of the month and these have been a lifesaver. They didn't budge through the night, are easy to apply & take off, plus definitely reduced my urge to pick at my skin.
BRIANA
Meet CUT-02™
Our Proprietary Enzyme
The CUT-02™ enzyme is made for precision: it specifically kills C. acnes, the bacteria responsible for acne, and leaves the skin's beneficial bacteria unharmed.
Unlike traditional acne treatments like antibiotics or benzoyl peroxide that destroy all bacteria, good and bad, the CUT-02™ enzyme's targeted approach means clearer skin, less drying and irritation, and a quicker return to a healthy, balanced microbiome.
99.9 %
of C. acnes bacteria killed within 1 hour without harming beneficial bacteria*
93 %
with mild to severe acne saw improvement after 2 weeks **
89 %
said their skin had less redness**
95 %
said it was non-irritating**
*Based on in vitro data of CUT 02™ enzyme
**Based on 8-week clinical trial of 19 adults with mild to severe acne.
99.9 %
of C. acnes bacteria killed within 1 hour without harming beneficial bacteria*
97 %
saw fewer breakouts**
81 %
reduction in inflamed pimples**
95 %
experienced no irritation**
*Based on in vitro data of CUT-02™ enzyme
**Based on a clinical trial of 32 adults with mild to severe acne
Meet CUT-02™
Our Proprietary Enzyme
The CUT-02™ enzyme is made for precision: it specifically kills C. acnes, the bacteria responsible for acne, and leaves the skin's beneficial bacteria unharmed.
Unlike traditional acne treatments like antibiotics or benzoyl peroxide that destroy all bacteria, good and bad, the CUT-02™ enzyme's targeted approach means clearer skin, less drying and irritation, and a quicker return to a healthy, balanced microbiome.
ACNE + THE MICROBIOME
The skin’s microbiome is an ecosystem in miniature, with countless microorganisms living on and within our skin.
Clear skin starts with balance
Your skin is home to millions of tiny microbes — and that’s a good thing.
In a healthy pore, oil production is balanced, dead skin sheds naturally, and helpful bacteria keep everything in check.
The pore gets clogged + C. acnes bacteria proliferates
Sometimes your skin produces too much oil. When it mixes with dead skin, your pore gets clogged.
Inside this blocked pore, acne-causing C. acnes bacteria multiply rapidly, triggering inflammation that leads to redness, swelling, and painful breakouts.
CUT-02 is a smarter, precision solution
CUT-02™ is a patented precision enzyme designed to target C. acnes without disrupting the good bacteria on your skin.
It helps restore the balance of your microbiome so your skin can actually function the way it’s supposed to.
Harsh treatments can lead to more problems
In contrast, traditional acne treatments like benzoyl peroxide and antibiotics don’t just target bad bacteria—they wipe out your entire skin ecosystem.
This can disrupt your skin’s natural balance, causing dryness, irritation, and even more breakouts over time.
MEET OUR CLINICAL ADVISORY TEAM
FAQS
How are hypothesis™ acne products different from other acne treatments?
Acne treatments like benzoyl peroxide and antibiotics kill bacteria broadly — including the good bacteria your skin needs — and often cause dryness, redness, and irritation. Our patented CUT-02 precision enzyme is different: it targets only acne-causing C. acnes bacteria while preserving the rest of your skin’s helpful microbiome. The result is effective acne care that's gentle enough for daily use, without the harsh side effects that make conventional treatments hard to stick with, and a healthier, more balanced microbiome.
How do I use hypothesis™ acne products in my daily routine?
Start with one application daily: in the evening, cleanse skin with the Daily Acne Cleanser, then apply the Acne Precision Serum. Once the Acne Precision Serum has fully absorbed into the skin, apply a moisturizer as needed and leave on overnight. Increase to twice daily application (morning and evening) if well-tolerated. Apply Precision Microdart Blemish Patches as needed to clean, dry skin to address early, under-the-surface pimples.
Our acne products are designed to work synergistically with one another, and the Daily Acne Cleanser is specifically formulated to be compatible with our precision acne products with the CUT-02™ enzyme. If you use other serums or treatments in your regimen, we recommend applying them after the Daily Acne Cleanser and before the Acne Precision Serum.
Note: As products with salicylic acid can increase your skin’s sun sensitivity, use an SPF during the day.
Where can I apply hypothesis™ acne products?
Our acne formulas can be applied anywhere on your face or body where you’re experiencing breakouts. As with all our products, our acne formulas are safe for use around the eyes, dermatologist approved, and rigorously clinically tested for safety and efficacy. We recommend applying liberally to irritated, acne-prone skin, or anywhere you typically have acne blemishes.
How long does it take to see results?
You should typically start to see improvements within one to two weeks, with the most substantial results building over the full 8 weeks — particularly during weeks 4–8. In our 8-week clinical trial, 71% of participants noticed improvement after one week and 93% saw a reduction in acne within two weeks. Over the full 8 weeks, participants reported reduced oiliness, redness, and comedones, as well as more even skin tone.
As with many acne treatments, consistent daily use is key — it takes time for the microbiome to rebalance and inflammation to calm.
For the Precision Microdart Blemish Patches, results are visible after a single 6–8 hour application. In clinical testing, 94% of participants said the patch reduced the progression of a pimple after one application.
Are hypothesis™ acne products safe for sensitive skin?
Yes, hypothesis™ acne products are specifically formulated with sensitive skin in mind. Our CUT-02™ enzyme works by targeting C. acnes bacteria only, and has no effect on skin cells or the skin barrier. That means it doesn't cause the dryness, peeling, or irritation associated with conventional acne treatments like benzoyl peroxide. All hypothesis™ acne products have been tested on sensitive skin panels using the gold-standard HRIPT (Human Repeat Insult Patch Test) protocol and found to be non-irritating and safe for sensitive skin. Our products have also undergone EpiOcular testing, confirming they are safe for use around the delicate eye area. In our clinical trial, 95% of participants said the Acne Precision Serum was non-irritating after 8 weeks of daily use.