












Eczema Travel Trio
Limited Time Value Kit
($69.97 value)
A limited-edition, travel-friendly eczema care trio, tailored for life on the go: Our easy-to-use Precision Healing Spray delivers real relief with our patented TPZ-01™ enzyme to keep Staph aureus bacteria in check—perfect for quick application to face, body, and hard-to-reach areas. Plus, you get portable travel sizes of our Eczema Precision Hydrogel & Eczema Therapy Cream to strategically target Staph aureus & seal in moisture for real relief when you’re out and about.
3-piece Eczema Travel Trio includes:
Precision Healing Spray 100 mL
Eczema Precision Hydrogel 30 ml
Eczema Therapy Cream 30 ml
Free shipping on US orders over $50
Details
Dermatologist Approved
NEA Accepted
EWG Verified®
Safe for Eye Area
Certified Microbiome Friendly
Hypoallergenic
Fragrance Free
Steroid FreeIngredients
How To Use













ECZEMA THERAPY CREAM
This deeply hydrating moisturizer is designed to work in parallel with our patented TPZ-01™ enzyme to repair the skin barrier. Made with 1% colloidal oatmeal and ceramides, this pH-balanced formula relieves the itch of eczema and supports an optimal pH level for a healthy microbiome.

PRECISION HEALING SPRAY + ECZEMA PRECISION HYDROGEL
Made with our patented TPZ-01™ enzyme, these two formulas are the first treatments to address the skin’s microbiome imbalance head on, targeting and killing eczema-associated Staph aureus bacteria to break the cycle of damage and irritation so skin can finally heal.
Our Eczema Precision Hydrogel delivers advanced eczema relief in a cooling gel texture, with pro-vitamin B5 and colloidal oatmeal for lasting comfort and symptom reduction. Our easy-to-use Precision Healing Spray offers the same patented TPZ-01™enzyme technology in a convenient spray format with soothing allantoin—perfect for face, body, and hard-to-reach areas whenever irritated skin needs quick calming.



ECZEMA THERAPY CREAM
This deeply hydrating moisturizer is designed to work in parallel with our patented TPZ-01™ enzyme to repair the skin barrier. Made with 1% colloidal oatmeal and ceramides, this pH-balanced formula relieves the itch of eczema and supports an optimal pH level for a healthy microbiome.
PRECISION HEALING SPRAY + ECZEMA PRECISION HYDROGEL
Made with our patented TPZ-01™ enzyme, these two formulas are the first treatments to address the skin’s microbiome imbalance head on, targeting and killing eczema-associated Staph aureus bacteria to break the cycle of damage and irritation so skin can finally heal.
Our Eczema Precision Hydrogel delivers advanced eczema relief in a cooling gel texture, with pro-vitamin B5 and colloidal oatmeal for lasting comfort and symptom reduction. Our easy-to-use Precision Healing Spray offers the same patented TPZ-01™enzyme technology in a convenient spray format with soothing allantoin—perfect for face, body, and hard-to-reach areas whenever irritated skin needs quick calming.









Eczema Precision Hydrogel
Relieves irritation + itching from eczema


RESULTS
2.5x
more effective than a standard eczema treatment*
85%
reduction in eczema-associated Staph aureus bacteria on the skin*
100%
of participants saw reduced eczema symptoms within 2 weeks*
*Based on a 2-week clinical trial of 24 adults with moderate to severe eczema comparing Hypothesis Eczema Precision Hydrogel to a product containing over-the-counter levels of colloidal oatmeal.
Precision Healing Spray
Soothes flare-ups + calms eczema-prone skin


RESULTS
100%
100% of participants saw immediate improvement in skin barrier function that lasted all day*
97%
experienced instant improvement in hydration**
95%
agreed the spray is non-irritating and gentle on skin**
*Based on a clinical trial of 33 adults with damaged skin barriers.
**Based on a 7-day clinical study of 34 adults with dry skin.
Eczema Therapy Cream
Hydrates dry skin + restores the skin barrier


RESULTS
96%
said it nourished and improved dry skin*
91%
saw improved hydration for 24 hours after a single use*
100%
of participants saw immediate improvement in skin barrier function that lasted all day**
*Based on a 7-day clinical study of 34 adults with dry skin.
**Based on a clinical trial of 33 adults with damaged skin barriers.
Within 1–2 days my inflammation is way down, and in less than a week it is almost gone...It really has worked better than anything that I have tried.
I noticed improvements after the first couple of uses and within a few weeks the flaking is now very minimal. I'm pretty mind-blown…I really can't get over how well this worked on my skin. 10/10 can't recommend this enough.
Not gonna lie, I stole some of this product I got for my daughter for myself!…Helps relieve the tightness and soothes the cracks both she and I get. It feels rich and thick—we both really enjoy using it!



Smart Science, By Design
WITH TPZ-01™ |
COLLOIDAL OATMEAL |
BLEACH BATHS |
STEROID CREAMS |
PRESCRIPTION DRUGS |
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|---|---|---|---|---|---|
| Treats eczema symptoms | ![]() |
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| Targets eczema-associated S. aureus | ![]() |
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| Preserves the skin’s beneficial microbiome | ![]() |
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| Patented technology | ![]() |
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| No side effects | ![]() |
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FAQS
How is this different from other eczema treatments?
Studies show that people with eczema have much higher levels of a bacteria called Staphylococcus aureus on their skin, particularly during flare-ups. Once on the skin, Staphylococcus aureus—also known as Staph, Staph aureus, or S. aureus—can secrete toxins that damage the skin barrier, increase itching, and activate the immune system. The more Staph aureus on skin, the more severe the eczema symptoms—yet standard eczema treatments like moisturizers and steroid creams do not address this underlying imbalance in the eczema skin microbiome.
At Hypothesis, we’re using biotechnology to develop clinically validated skincare that tackles the eczema microbiome head on. Our patented TPZ-01™ precision enzyme targets and kills eczema-associated Staph aureus bacteria while preserving the rest of your skin’s helpful microbiome, helping to reestablish a healthy, balanced microbiome that breaks the cycle of itching, skin barrier damage, and flare-ups.
Do Hypothesis products contain steroids or fragrance?
All Hypothesis products are both steroid-free and fragrance-free. We avoid known irritants in our formulas and use rigorously screened, cutting-edge ingredients with proven track records of both gentleness and efficacy. Our clinically tested formulas are dermatologist-approved, accepted by the National Eczema Association (NEA), EWG Verified™ for Eczema, certified Microbiome Friendly by MyMicrobiome for both infants and adults with eczema, safe for use in the delicate eye area, and hypoallergenic.
Where can I apply Hypothesis products?
The Eczema Precision Hydrogel, Precision Healing Spray, and Eczema Therapy Cream can all be applied anywhere externally on your face or body where you’re experiencing eczema symptoms, including eyelids. All formulas are safe for use around the eyes, dermatologist approved, and accepted by the National Eczema Association (NEA). We recommend applying liberally to itchy, irritated, or dry skin, or anywhere you typically have eczema flare-ups.
How do I use Hypothesis products in my daily routine?
We recommend using our Eczema Precision Hydrogel with our patented TPZ-01™ precision enzyme at least twice a day (morning and night), but more often if needed for additional soothing. Our Precision Healing Spray with TPZ-01™ is a convenient spray format designed for quick application to hard-to-reach areas or on-the-go use throughout the day. It can be used as a standalone soothing spray, or used in conjunction with our Eczema Precision Hydrogel for a double dose of the TPZ-01™ enzyme. Our Eczema Therapy Cream is a moisturizer designed to work in tandem with the TPZ-01™ enzyme, and can be used after the Precision Healing Spray or Eczema Precision Hydrogel to seal in additional moisture. Apply the Eczema Therapy Cream any time your skin needs immediate hydration or skin barrier repair.
How long does it take to see results?
In clinical studies of the Eczema Precision Hydrogel, most users saw initial improvement in their eczema symptoms within a week, with best results after 2–4 weeks of twice-daily use and an 85% reduction in eczema-associated Staph aureus bacteria on the skin. In clinical studies of the Precision Healing Spray, users experienced instant relief of dry, cracked skin immediately after use and 97% saw improved hydration within 30 minutes. Most users saw additional improvement in flare-ups and irritation within a week, with best results after 2–4 weeks of twice-daily use.In clinical studies, the Eczema Therapy Cream immediately hydrates and strengthens the skin barrier with benefits that last all day.
Reviews
Clinically tested, next-generation formulas that treat the bacteria behind flare-ups to visibly transform skin.







WITH TPZ-01™
