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PRECISION HEALING SPRAY
4.4
Rated 4.4 out of 5 stars
4.4
ECZEMA THERAPY CREAM
4.6
Rated 4.6 out of 5 stars
4.6
ECZEMA PRECISION HYDROGEL
4.4
Rated 4.4 out of 5 stars
4.4
ECZEMA PRECISION KIT
4.7
Rated 4.7 out of 5 stars
4.7
$59.99 $69.97

Eczema Travel Trio

Bundle and Save
($69.97 value)

4.4
Rated 4.4 out of 5 stars
4.4

A travel-friendly eczema care trio, tailored for life on the go: Our easy-to-use Precision Healing Spray delivers real relief with our patented TPZ-01™ enzyme to keep Staph aureus bacteria in check—perfect for quick application to face, body, and hard-to-reach areas. Plus, you get portable travel sizes of our Eczema Precision Hydrogel & Eczema Therapy Cream to strategically target Staph aureus & seal in moisture for real relief when you’re out and about.

3-piece Eczema Travel Trio includes:
Precision Healing Spray 100 mL
Eczema Precision Hydrogel 30 ml
Eczema Therapy Cream 30 ml

Benefits

Precision Healing Spray

  • Targets and kills flare-causing Staph aureus bacteria from head to toe
  • Provides instant, convenient relief 
  • Soothes irritated flare-ups on the go

Eczema Precision Hydrogel

  • Targets and kills eczema-causing Staph aureus bacteria
  • Relieves itching, redness, and irritation from eczema
  • Preserves the skin’s beneficial microbiome

Eczema Therapy Cream

  • Repairs and strengthens the skin barrier
  • Provides all-day hydration and relief for dry skin
  • Relieves itching and irritation from eczema
Dermatologist Approved
NEA Accepted
EWG Verified®
Safe for Eye Area
Certified Microbiome Friendly
Hypoallergenic
Fragrance Free
Steroid Free
Ingredients

TPZ-01™ Enzyme 
Our patented TPZ-01™ enzyme selectively targets and kills 99.99% of eczema-associated Staph aureus bacteria within 5 minutes while preserving beneficial microorganisms.

Colloidal Oatmeal 
This oat-derived skin protectant soothes itching and calms irritation from eczema.

0.5% Allantoin
This multifunctional skin protectant soothes and relieves irritation and flare-ups.

Betaine
Naturally derived from beets, betaine provides long-term hydration & protects against future irritation.

Pro-Vitamin B5 + Sorbitol
Two potent moisture magnets that hydrate, comfort, and help replenish the skin barrier.

Full Ingredient List

Precision Healing Spray
Active Ingredient: 0.5% Allantoin
Inactive Ingredients:
Water/Aqua/Eau, Betaine, Sorbitol, Arginine HCl, Hydroxyethylpiperazine Ethane Sulfonic Acid, Panthenol, Sodium Chloride, Methionine, Calcium Chloride, Methylparaben, Sodium Hydroxide, Acetyl Cysteine, Hydrochloric Acid, sr-(Staphylococcus sp. Polypeptide-1 Dipeptide-81 Streptococcus Suis Phage Polypeptide-1 Dipeptide-19 Hexapeptide-40), Hydroxypropyl Methylcellulose

Eczema Precision Hydrogel
Active Ingredient: 0.01% Colloidal Oatmeal
Inactive Ingredients:
Water/Aqua/Eau, Sorbitol, Arginine HCl, Hydroxyethylpiperazine Ethane Sulfonic Acid, Panthenol, Sodium Chloride, Hydroxypropyl Methylcellulose, Methionine, Calcium Chloride, Methylparaben, Sodium Hydroxide, Acetyl Cysteine, sr-(Staphylococcus sp. Polypeptide-1 Dipeptide-81 Streptococcus Suis Phage Polypeptide-1 Dipeptide-19 Hexapeptide-40), Hydrochloric Acid

Eczema Therapy Cream
Active Ingredient: 1% Colloidal Oatmeal
Inactive Ingredients:
Water/Aqua/Eau, Glycerin, Caprylic/Capric Triglyceride, Cetyl Alcohol, Bis-Diglyceryl Polyacyladipate-2, Jojoba Esters, Polyglyceryl-2 Stearate, Butyrospermum Parkii (Shea) Butter, Bisabolol, Zingiber Officinale (Ginger) Extract, Ceramide NP, Ceramide AP, Ceramide EOP, Phytosphingosine, Cholesterol, Sodium PCA, Urea, Trehalose, Sodium Hyaluronate, Hexylene Glycol, Polyquaternium-51, Triacetin, Caprylyl Glycol, Sodium Lauroyl Lactylate, Tocopherol, Tocopheryl Acetate, Dimethicone, Ammonium Acryloyldimethyltaurate/VP Copolymer, Hydroxyacetophenone, Glyceryl Stearate, Stearyl Alcohol, Carbomer, Xanthan Gum, 1,2-Hexanediol, Citric Acid, Sodium Hydroxide, Tetrasodium Glutamate Diacetate, Ethylhexylglycerin

How To Use

Shake and apply Eczema Precision Hydrogel to eczema-prone skin at least twice daily (morning and evening) or as often as desired. Let absorb into the skin for 5 minutes before layering on other skincare. Apply Precision Healing Spray onto face and body throughout the day to soothe irritation and keep Staph aureus bacteria in check. Apply Eczema Therapy Cream all over body and face as often as needed to lock in moisture, soothe itch, and calm dry, eczema-prone skin.

ECZEMA THERAPY CREAM

This deeply hydrating moisturizer is designed to work in parallel with our patented TPZ-01™ enzyme to repair the skin barrier. Made with 1% colloidal oatmeal and ceramides, this pH-balanced formula relieves the itch of eczema and supports an optimal pH level for a healthy microbiome.

PRECISION HEALING SPRAY + ECZEMA PRECISION HYDROGEL

Made with our patented TPZ-01™ enzyme, these two formulas are the first treatments to address the skin’s microbiome imbalance head on, targeting and killing eczema-associated Staph aureus bacteria to break the cycle of damage and irritation so skin can finally heal.

Our Eczema Precision Hydrogel delivers advanced eczema relief in a cooling gel texture, with pro-vitamin B5 and colloidal oatmeal for lasting comfort and symptom reduction. Our easy-to-use Precision Healing Spray offers the same patented TPZ-01™enzyme technology in a convenient spray format with soothing allantoin—perfect for face, body, and hard-to-reach areas whenever irritated skin needs quick calming.

ECZEMA THERAPY CREAM

This deeply hydrating moisturizer is designed to work in parallel with our patented TPZ-01™ enzyme to repair the skin barrier. Made with 1% colloidal oatmeal and ceramides, this pH-balanced formula relieves the itch of eczema and supports an optimal pH level for a healthy microbiome.

PRECISION HEALING SPRAY + ECZEMA PRECISION HYDROGEL

Made with our patented TPZ-01™ enzyme, these two formulas are the first treatments to address the skin’s microbiome imbalance head on, targeting and killing eczema-associated Staph aureus bacteria to break the cycle of damage and irritation so skin can finally heal.

Our Eczema Precision Hydrogel delivers advanced eczema relief in a cooling gel texture, with pro-vitamin B5 and colloidal oatmeal for lasting comfort and symptom reduction. Our easy-to-use Precision Healing Spray offers the same patented TPZ-01™enzyme technology in a convenient spray format with soothing allantoin—perfect for face, body, and hard-to-reach areas whenever irritated skin needs quick calming.

Real People, Real Results

I LOVE that I can use it on my child repeatedly, for as long as needed…I didn’t have to be concerned about how long she was using it, like I do with topical steroids, and the fact that IT WORKED made both of us feel better.

KIM

I knew I had a staph problem on my skin…I noticed improvements after the first couple of uses and within a few weeks the flaking is now very minimal.  I’m pretty mind blown…10/10 can’t recommend this enough.

DARCI

My 6-year old has struggled with eczema since he was a baby…To say the results were incredible is an understatement.  Within just a couple of weeks, his red, itchy skin completely returned to normal.

CHRISTA

I had this angry red patch on my hand for about 3 months.  The doctors prescribed me antibiotics, steroid creams, etc. and nothing worked.  I ordered Hypothesis as a last ditch effort and was shocked by the results…My patch was cleared up in a week and a half.

SOPHIA

I have tried everything on the market & I had lost hope.  I ran into an Instagram profile of a young woman…I was her results and decided to try this brand.  Initial reaction, I loved that it relieved the itching…in no time, it cleared up my flare.

HELEN

Within 1 to 2 days my inflammation is way down, and in less than a week it is almost gone…It really has worked better than anything that I have tried.

ERIN

I love the texture of the product.  It soothes my skin and applies very easily…can put it on right before bed or right before applying makeup.  My redness and flakiness have improved and feels so much better

JESSICA

Where has this been my whole life? This formula is incredible and truly helped my eczema skin so much. It also helped me to realize that staph aureus was definitely playing a role in my flares…

BRYANA

If Hypothesis didn’t exist, I would have thrown in the towel and let urgent care shoot me up with steroids after 3.5 years of battling TSW…My skin felt immense relief after using the Eczema Therapy Cream

CHELSEA

Y’all please get this!!  I’ve been having eczema flares on my hands and arm for about 3 years now and no product has worked…Hypothesis has been a game changer.  I’m less flakey, not that irritated when I put on long sleeves, and minimal itching.

TAHJ

It definitely has been a god send to finally have something that helps me to manage my eczema.

JANE

I love how smoothly it goes on and that it is easy to apply on the most sensitive of skin. The improvements in my skin were noticeable after just a few uses. I have added this as a permanent product in my eczema rotation!

BRYANA

Eczema Precision Hydrogel

Relieves irritation + itching from eczema

RESULTS

2.5x

more effective than a standard eczema treatment*

85%

reduction in eczema-associated Staph aureus bacteria on the skin*

100%

of participants saw reduced eczema symptoms within 2 weeks*

*Based on a 2-week clinical trial of 24 adults with moderate to severe eczema comparing Hypothesis Eczema Precision Hydrogel to a product containing over-the-counter levels of colloidal oatmeal.

Precision Healing Spray

Soothes flare-ups + calms eczema-prone skin

RESULTS

100%

100% of participants saw immediate improvement in skin barrier function that lasted all day*

97%

experienced instant improvement in hydration**

95%

agreed the spray is non-irritating and gentle on skin**

*Based on a clinical trial of 33 adults with damaged skin barriers.
**Based on a 7-day clinical study of 34 adults with dry skin.

Eczema Therapy Cream

Hydrates dry skin + restores the skin barrier

RESULTS

96%

said it nourished and improved dry skin*

91%

saw improved hydration for 24 hours after a single use*

100%

of participants saw immediate improvement in skin barrier function that lasted all day**

*Based on a 7-day clinical study of 34 adults with dry skin.
**Based on a clinical trial of 33 adults with damaged skin barriers.

Smart Science, By Design

COLLOIDAL
OATMEAL
BLEACH
BATHS
STEROID
CREAMS
PRESCRIPTION
DRUGS
Treats eczema symptoms
Targets eczema-associated S. aureus
Preserves the skin’s beneficial microbiome
Patented technology
No side effects
*data on file

FAQS

How is this different from other eczema treatments?

​​Studies show that people with eczema have much higher levels of a bacteria called Staphylococcus aureus on their skin, particularly during flare-ups.  Once on the skin, Staphylococcus aureus—also known as Staph, Staph aureus, or S. aureus—can secrete toxins that damage the skin barrier, increase itching, and activate the immune system. The more Staph aureus on skin, the more severe the eczema symptoms—yet standard eczema treatments like moisturizers and steroid creams do not address this underlying imbalance in the eczema skin microbiome.

At Hypothesis, we’re using biotechnology to develop clinically validated skincare that tackles the eczema microbiome head on. Our patented TPZ-01™ precision enzyme targets and kills eczema-associated Staph aureus bacteria while preserving the rest of your skin’s helpful microbiome, helping to reestablish a healthy, balanced microbiome that breaks the cycle of itching, skin barrier damage, and flare-ups.

Do Hypothesis products contain steroids or fragrance?

All Hypothesis products are both steroid-free and fragrance-free. We avoid known irritants in our formulas and use rigorously screened, cutting-edge ingredients with proven track records of both gentleness and efficacy. Our clinically tested formulas are dermatologist-approved, accepted by the National Eczema Association (NEA), EWG Verified™ for Eczema, certified Microbiome Friendly by MyMicrobiome for both infants and adults with eczema, safe for use in the delicate eye area, and hypoallergenic.

Where can I apply Hypothesis products?

The Eczema Precision Hydrogel, Precision Healing Spray, and Eczema Therapy Cream can all be applied anywhere externally on your face or body where you’re experiencing eczema symptoms, including eyelids. All formulas are safe for use around the eyes, dermatologist approved, and accepted by the National Eczema Association (NEA). We recommend applying liberally to itchy, irritated, or dry skin, or anywhere you typically have eczema flare-ups.

How do I use Hypothesis products in my daily routine?

We recommend using our Eczema Precision Hydrogel with our patented TPZ-01™ precision enzyme at least twice a day (morning and night), but more often if needed for additional soothing. Our Precision Healing Spray with TPZ-01™ is a convenient spray format designed for quick application to hard-to-reach areas or on-the-go use throughout the day. It can be used as a standalone soothing spray, or used in conjunction with our Eczema Precision Hydrogel for a double dose of the TPZ-01™ enzyme. Our Eczema Therapy Cream is a moisturizer designed to work in tandem with the TPZ-01™ enzyme, and can be used after the Precision Healing Spray or Eczema Precision Hydrogel to seal in additional moisture. Apply the Eczema Therapy Cream any time your skin needs immediate hydration or skin barrier repair.

How long does it take to see results?

In clinical studies of the Eczema Precision Hydrogel, most users saw initial improvement in their eczema symptoms within a week, with best results after 2–4 weeks of twice-daily use and an 85% reduction in eczema-associated Staph aureus bacteria on the skin. In clinical studies of the Precision Healing Spray, users experienced instant relief of dry, cracked skin immediately after use and 97% saw improved hydration within 30 minutes. Most users saw additional improvement in flare-ups and irritation within a week, with best results after 2–4 weeks of twice-daily use.In clinical studies, the Eczema Therapy Cream immediately hydrates and strengthens the skin barrier with benefits that last all day.

Reviews

89%would recommend these products
4.4
Rated 4.4 out of 5 stars
Based on 188 reviews
Total 5 star reviews: 113 Total 4 star reviews: 54 Total 3 star reviews: 16 Total 2 star reviews: 2 Total 1 star reviews: 3
188 reviews
  • NR
    Naiya R.
    Reviewing
    ECZEMA PRECISION HYDROGEL
    I recommend this product
    What are your skin challenges? Eczema, Redness, Itchiness, Skin thickening, Dryness
    What is your primary area of concern? Scalp, Arms
    What did you like about the product? Visible results, Soothed irritation, Itch relief, Barrier repair, Hydrating
    Would you recommend this product? Yes
    Rated 5 out of 5 stars
    8 months ago
    Eczema journey

    Great product, definitely would recommend improved my eczema and decreased itching over time with use especially at night which I was really happy about. Skin texture also improved and is now less rough. I believe with continued use it will continue to improve even more.

  • KW
    Kim W.
    Reviewing
    ECZEMA PRECISION HYDROGEL
    I recommend this product
    What are your skin challenges? Psoriasis, Itchiness, Dryness, Redness, Skin thickening
    What is your primary area of concern? Hands
    What did you like about the product? Visible results, Everyday use, Gentle formula, Fast absorbing
    Would you recommend this product? Yes
    Rated 5 out of 5 stars
    8 months ago
    Quickly reduced predictable flare up

    My daughter always has her hands flare up at the start of school, with the new environment and soaps and sharing things with other kids. It can get really bad and be super painful. This year I got the Hypothesis Precision Hydrogel to treat it. It immediately prevented her itching, redness, and swelling from getting any worse, which was a big win for us. After two days she still complained about some discomfort, so I gave her one treatment of topical steroids and continued using the Precision Hydrogel. That reduced the swelling, and the Hypothesis did the rest! Only one treatment of steroid cream, and the Hypothesis healed the bumps, redness, itchiness, swelling. I like that it absorbs quickly, and leaves a smooth feel to the skin. It was fast and easy to use, and didn't leave any residue on things the way ointments can. And I LOVE that I can use it on my child repeatedly, for as long as needed, without worrying about any negative effects from steroids, or stickiness from thick creams or ointments. The fact that I didn't have to be concerned about how long she was using it, like I do with topical steroids, and the fact that IT WORKED made both of us feel better. Next year, I'm just going to start treating her with the Hypothesis from the start of the school year, not even wait for any signs of an issue. There's no down side, and I hope that it will prevent any uncomfortable symptoms before they even start. Very happy that this new treatment option available!!

  • NR
    Naiya R.
    Reviewing
    ECZEMA THERAPY CREAM
    I recommend this product
    What are your skin challenges? Eczema, Redness, Itchiness, Skin thickening, Dryness
    What is your primary area of concern? Arms, Scalp
    What did you like about the product? Soothing relief, Redness reduction, Fast absorbing
    Rated 5 out of 5 stars
    8 months ago
    Eczema journey

    I loved the cream it was awesome and total game changer. Definitely helped with itching and soothing my skin. Texture is improved so much and skin looks so much healthier

  • NW
    Natalie W.
    Reviewing
    ECZEMA THERAPY CREAM
    I recommend this product
    What are your skin challenges? Psoriasis, Redness, Skin thickening
    What is your primary area of concern? Legs, Arms
    What did you like about the product? Hydrating, Gentle formula, Fast absorbing, Versatile
    Rated 5 out of 5 stars
    9 months ago
    Moisturized the dry patches on my skin

    I really loved this cream. It's unscented and calms the dry patches that my psoriasis creates. I used it once a day on my whole body and another targeted on the dry spots where I also applied the spray. I have used it up and would love to use more!

  • AE
    Ariane E.
    Reviewing
    ECZEMA THERAPY CREAM
    I recommend this product
    What are your skin challenges? Eczema, Itchiness, Dryness
    What is your primary area of concern? Face, Legs, Trunk
    What did you like about the product? Hydrating, Everyday use, Gentle formula, Fast absorbing
    Rated 5 out of 5 stars
    9 months ago
    Gentle enough for toddler skin!

    We loved the cream for everything. I found that I needed less of the product over time as the dryness improved immediately and a little went a long way to keeping the skin hydrated.