Studies show that people with eczema have much higher levels of a bacteria called Staphylococcus aureus on their skin, particularly during flare-ups.  Once on the skin, Staphylococcus aureus—also known as Staph, Staph aureus, or S. aureus—can secrete toxins that damage the skin barrier, increase itching, and activate the immune system. The more Staph aureus on skin, the more severe the eczema symptoms—yet standard eczema treatments like moisturizers and steroid creams do not address this underlying imbalance in the eczema skin microbiome.

At Hypothesis, we’re using biotechnology to develop clinically validated skincare that tackles the eczema microbiome head on. Our patented TPZ-01™ precision enzyme targets and kills eczema-associated Staph aureus bacteria while preserving the rest of your skin’s helpful microbiome, helping to reestablish a healthy, balanced microbiome that breaks the cycle of itching, skin barrier damage, and flare-ups.

All Hypothesis products can be applied anywhere externally on your face or body where you’re experiencing eczema symptoms, including eyelids. All of our formulas are safe for use around the eyes, dermatologist tested, and have received the National Eczema Association (NEA) Seal of Acceptance. We recommend applying liberally to itchy, irritated, or dry skin, or anywhere you typically have eczema flare-ups. 

As with all new skincare products, we recommend doing a patch test before first use, especially if you have very sensitive skin or known allergies. Apply a small amount to an area like the inside of your wrist or behind your ear, wait 24 hours, and check for any reaction before applying to larger areas or your face.

We recommend using our Eczema Precision Hydrogel with our patented TPZ-01™ precision enzyme at least twice a day (morning and night), but more often if needed for additional soothing. Our Precision Healing Spray with TPZ-01™ is a convenient spray format designed for quick application to hard-to-reach areas or on-the-go use throughout the day. It can be used as a standalone soothing spray, or used in conjunction with our Eczema Precision Hydrogel for a double dose of the TPZ-01™ enzyme. Our Eczema Therapy Cream is a moisturizer designed to work in tandem with the TPZ-01™ enzyme, and can be used after the Precision Healing Spray or Eczema Precision Hydrogel to seal in additional moisture. Apply the Eczema Therapy Cream any time your skin needs immediate hydration or skin barrier repair.

Yes, our hypoallergenic, dermatologist-approved formulas are extensively tested by independent certifying organizations to meet the highest standards for safety and gentleness on sensitive skin. Our formulas are steroid-free and fragrance-free, have received the National Eczema Association (NEA) Seal of Acceptance, and are EWG Verified™ for meeting stringent standards for safety and sustainability. Our products are also certified Microbiome Friendly by MyMicrobiome for both infants and adults.

Yes,  all of our products are dermatologist tested and meet the highest standards for safety. In addition, our products are EWG Verified™ for Eczema, certified Microbiome Friendly by MyMicrobiome for infants and adults, and NEA Accepted.

Our eczema products are formulated without ingredients that are contraindicated during pregnancy, such as retinoids, hydroquinone, high-level salicylic acid, essential oils, or certain organic/chemical sunscreen filters. As with all new skincare products, we recommend consulting with your doctor or healthcare provider before use.

Our products are formulated and manufactured in the United States with globally sourced ingredients.

Yes, you can use our products even if you don’t have eczema. All of our ingredients are carefully selected to strengthen the skin’s protective moisture barrier, calm irritation, and support the skin’s beneficial microbiome. 

We're committed to sustainable packaging that protects both our formulas and the environment. All Hypothesis packaging is made with 50% post-consumer recycled (PCR) materials and our outer boxes are printed on FSC-certified paper, ensuring responsible sourcing and reduced environmental impact.

Our Eczema Precision Hydrogel and Precision Healing Spray feature airless packaging components that protect the stability and efficacy of our patented TPZ-01™ enzyme. This airless technology prevents contamination and extends product freshness.

All Hypothesis products are both steroid-free and fragrance-free. We avoid known irritants in our formulas and use rigorously screened, cutting-edge ingredients with proven track records of both gentleness and efficacy. Our clinically tested formulas are dermatologist-approved, accepted by the National Eczema Association (NEA), EWG Verified™, certified Microbiome Friendly by MyMicrobiome for both infants and adults with eczema, safe for use in the delicate eye area, and hypoallergenic. 

Yes. We’ve applied rigorous scientific standards to ensure every Hypothesis formula is both safe and effective. All of our dermatologist-approved, hypoallergenic products carry the most stringent certifications from leading organizations: EWG Verified™, accepted by the National Eczema Association (NEA), and certified Microbiome Friendly by MyMicrobiome for infants and adults.

Our formulations are carefully designed without common irritants: they are fragrance-free, steroid-free, phthalate-free, propylene glycol-free, and free of dyes and essential oils.

To preserve stability and protect sensitive skin, some of our products use methylparaben (0.15%), a short-chain preservative proven to be both safe and effective. Regulatory bodies including the FDA, the European Scientific Committee on Consumer Safety, and the Environmental Working Group have confirmed its safety at low concentrations. Importantly, robust preservation is essential for products supporting compromised skin barriers, helping prevent contamination from harmful bacteria and mold while maintaining the effectiveness of our breakthrough TPZ-01™ enzyme.

By prioritizing science-backed ingredient choices and maintaining the highest safety certifications across our line, we ensure every Hypothesis product delivers consistent, reliable relief you can trust.

TPZ-01™is a patented new precision enzyme (US patent no. 12,263,208) that specifically targets and kills eczema-associated Staphylococcus aureus (S. aureus) bacteria while preserving the skin’s beneficial microbiome. Existing eczema treatments like steroid creams and colloidal oatmeal moisturizers try to calm symptoms, but they don’t do anything to address the Staph aureus bacteria helping to drive those symptoms in the first place.  Reducing S. aureus bacteria is both the biggest gap and biggest opportunity for better eczema treatments. Our high-precision TPZ-01™ enzyme is designed to selectively target S. aureus while preserving the good bacteria on your skin, helping to restore a healthy microbiome and break the cycle that drives flare-ups. It's a key addition to your existing eczema regimen, not only reducing symptoms but killing the bacteria that cause those symptoms in the first place.

The TPZ-01™enzyme  is the product of 3+ years of research and development. It’s a new patented enzyme ingredient that specifically targets the harmful bacteria Staph aureus while protecting the good bacteria your skin needs to stay healthy. Treatments like steroid creams or moisturizers try to calm symptoms, but don’t do anything about the Staph aureus driving those symptoms in the first place, so flares can continue.

In an independent clinical study of formulations with the TPZ-01™ enzyme, Staph aureus on the skin was reduced by 85%. Our Eczema Precision Hydrogel was 2.5x more effective at reducing eczema symptoms than a standard colloidal oatmeal product.

Yes, our formulas made with TPZ-01™ enzyme are designed to work alongside existing eczema treatments and skincare regimens, including moisturizers, steroid creams, and prescription products. All three formulations (Eczema Precision Hydrogel, Precision Healing Spray, and Eczema Therapy Cream) can be integrated into your current routine. 

When using the Eczema Precision Hydrogel, we suggest waiting 5 minutes before layering on any additional products to allow the formula to fully absorb into skin. Let our Precision Healing Spray absorb before layering on additional products. Because no other products are focused on specifically reducing Staph aureus, adding TPZ-01™ to your regimen lets you address a root cause of eczema flares that is otherwise untreated. 

While our TPZ-01™ products focus on Staph aureus, our Eczema Therapy Cream focuses on the other side of the equation—repairing and restoring the skin barrier. Our Eczema Therapy Cream is optimized to be compatible with the TPZ-01™ enzyme.

In clinical studies of our Eczema Precision Hydrogel, most people noticed reduced itching, inflammation, and eczema symptoms within the first week, with even more significant improvement by week two. On average, users saw a 61% reduction in symptom intensity compared to 25% with a standard colloidal oatmeal treatment. Unlike some treatments that may initially cause irritation, our formulations typically provide immediate comfort and steady improvement. By reducing Staph aureus on the skin, you can break the cycle of inflammation and skin barrier damage and finally allow the skin to recover. 

Our steroid-free, NEA Accepted formulas are safe for children and certified Microbiome Friendly by MyMicrobiome for both adults and infants. All of our formulas have been extensively tested for safety and used in clinical trials with no side effects, including with long-term use. 

We recognize that everyone's skin is different and there are cases where Staph aureus may not play as central a role in causing symptoms. In our clinical trials, about 80% of people see very significant improvement when using our products with TPZ-01™, while the remaining 20% see more modest effects. The contribution of Staph aureus to symptoms is also stronger during active flare-ups, so it’s worth trying our products with TPZ-01™ at different points in your eczema cycle.

If you don't see the results you're hoping for, it may mean your eczema has different primary triggers that need different approaches.  We are always seeking feedback and data on people’s experiences with our products so we can better understand how our products can be the most effective.

All Hypothesis products are available for purchase on Hypothesis.bio. If you need assistance with your order, please contact customer service at hello@hypothesis.bio.

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Orders typically take 2–3 business days to process before shipping. You'll receive a confirmation email when your order ships, along with tracking information so you can follow its progress.

Please note that processing times may be slightly longer during peak periods or holidays. If you have any questions about your specific order, feel free to contact our customer service at hello@hypothesis.bio.

Once your purchase has been dispatched, you’ll receive an email with your tracking number. You can track your progress by viewing 'My Orders' in your account. Please note that during peak periods, deliveries may take longer than usual.

We start preparing orders right away, so cancellations aren’t always possible. If you’d like to cancel, email us as soon as you can at hello@hypothesis.bio. If your order is already on its way, no problem—you’ll still be able to return it once it arrives.

Yes! Our eczema care products are typically eligible for HSA and FSA spending. Since plans can vary, we suggest confirming eligibility with your provider.