








PRECISION HEALING SPRAY
Soothes flare-ups + calms eczema-prone skin
This easy-to-use spray provides immediate & long-term relief for flare-ups in eczema-prone skin. Made with soothing allantoin and our patented TPZ-01™ enzyme to target and kill eczema-associated Staph aureus bacteria, this convenient spray can be applied to face, body, and hard-to-reach areas whenever irritated skin needs quick calming.
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Details







Ingredients
How To Use









KEY INGREDIENTS
0.5% Allantoin
This multifunctional skin protectant soothes and relieves irritation and flare-ups.
Betaine
Naturally derived from beets, betaine provides long-term hydration & protects against future irritation.
Pro-Vitamin B5 + Sorbitol
Two potent moisture magnets that hydrate, comfort, and help replenish the skin barrier.

KEY INGREDIENTS
0.5% Allantoin
This multifunctional skin protectant soothes and relieves irritation and flare-ups.
Betaine
Naturally derived from beets, betaine provides long-term hydration & protects against future irritation.
Pro-Vitamin B5 + Sorbitol
Two potent moisture magnets that hydrate, comfort, and help replenish the skin barrier.



MEET TPZ-01™
99.99% of S. aureus bacteria killed within 5 minutes*
In a breakthrough for eczema care, our patented TPZ-01™ enzyme strategically zeroes in on eczema-associated Staph aureus bacteria, leaving the rest of the microbiome balanced for a stronger, more resilient skin barrier.
*Based on in vitro data of TPZ-01™ enzyme
MEET TPZ-01™
99.99% of Staph aureus bacteria killed within 5 minutes*
In a breakthrough for eczema care, our patented TPZ-01™ enzyme strategically zeroes in on eczema-associated Staph aureus bacteria, leaving the rest of the microbiome balanced for a stronger, more resilient skin barrier.
*Based on in vitro data of TPZ-01™ enzyme
Clinically Proven to Restore the Skin Barrier

100 %
of participants saw immediate improvement in skin barrier function that lasted all day*
97 %
experienced instant improvement in hydration**
95 %
agreed the spray is non-irritating and gentle on skin**
*Based on a clinical trial of 33 adults with damaged skin barriers.
**Based on a 7-day clinical study of 34 adults with dry skin.
Within 1–2 days my inflammation is way down, and in less than a week it is almost gone...It really has worked better than anything that I have tried.
Where has this been my whole life? This formula is incredible and truly helped my eczema skin so much. …a spray product is something I have never tried for my eczema and now I don't think I can ever go back.


Smart Science, By Design




FAQS
How is this different from other eczema treatments?
Studies show that people with eczema have much higher levels of a bacteria called Staphylococcus aureus on their skin, particularly during flare-ups. Once on the skin, Staphylococcus aureus—also known as Staph, Staph aureus, or S. aureus—can secrete toxins that damage the skin barrier, increase itching, and activate the immune system. The more Staph aureus on skin, the more severe the eczema symptoms—yet standard eczema treatments like moisturizers and steroid creams do not address this underlying imbalance in the eczema skin microbiome.
At Hypothesis, we’re using the science of biotechnology to develop clinically validated skincare that tackles the eczema microbiome head on. Our patented TPZ-01™ precision enzyme targets and kills eczema-associated Staph aureus bacteria while preserving the rest of your skin’s helpful microbiome, helping to reestablish a healthy, balanced microbiome that breaks the cycle of itching, skin barrier damage, and flare-ups.
Does the Precision Healing Spray contain steroids?
All Hypothesis products are both steroid-free and fragrance-free. We avoid known irritants in our formulas and use rigorously screened, cutting-edge ingredients with proven track records of both gentleness and efficacy. Our clinically tested formulas are dermatologist-approved, accepted by the National Eczema Association (NEA), certified Microbiome Friendly by MyMicrobiome, safe for use in the delicate eye area, and hypoallergenic.
Does the Precision Healing Spray contain fragrance?
The Precision Healing Spray is fragrance-free. We avoid known irritants in our formulas and use rigorously screened, cutting-edge ingredients with proven track records of both gentleness and efficacy. You may notice a mild, naturally-occurring scent from the amino acid methionine. Methionine is an antioxidant that helps maintain the stability of our patented TPZ-01™ enzyme while protecting the skin from free radicals and supporting the skin barrier. Rather than covering this natural scent with potentially irritating synthetic fragrances or chemical masking agents, we choose to keep our formula as streamlined as possible to minimize irritation. Methionine's scent is completely normal and should quickly fade as the formula absorbs into your skin.
Where can I apply the Precision Healing Spray?
The Precision Healing Spray can be applied anywhere externally on your face or body where you’re experiencing eczema symptoms, including eyelids. The convenient spray format is particularly good for quick soothing in hard to reach areas like the scalp and back. As with all our products, this formula is safe for use in the delicate eye area, dermatologist approved, and accepted by the National Eczema Association (NEA). We recommend applying liberally to itchy, irritated, or dry skin, or anywhere you typically have eczema flare-ups.
As with all new skincare products, we recommend doing a patch test before first use, especially if you have very sensitive skin or known allergies. Apply a small amount to an area like the inside of your wrist or behind your ear, wait 24 hours, and check for any reaction before applying to larger areas or your face.
How do I use Hypothesis products in my daily routine?
Our Precision Healing Spray with TPZ-01™ is a convenient spray format designed for quick application to hard-to-reach areas or on-the-go use throughout the day. It can be used as a standalone soothing spray, or used in conjunction with our Eczema Precision Hydrogel for a double dose of the TPZ-01™ enzyme. Our Eczema Therapy Cream is a moisturizer designed to work in tandem with the TPZ-01™ enzyme, and can be used after the Precision Healing Spray or Eczema Precision Hydrogel to seal in additional moisture. Apply the Eczema Therapy Cream any time your skin needs immediate hydration or skin barrier repair.
How long does it take to see results?
In clinical studies, users experienced instant relief of dry, cracked skin immediately after using the Precision Healing Spray, and 97% saw improved hydration within 30 minutes. Most users saw additional improvement in flare-ups and irritation within a week, with best results after 2–4 weeks of twice-daily use.
Is the Precision Healing Spray safe for babies and children?
Yes, all of our hypoallergenic, dermatologist-approved formulas are extensively tested by independent certifying organizations to meet the highest standards for safety and gentleness on sensitive skin. Our formulas are steroid-free and fragrance-free, have received the National Eczema Association (NEA) Seal of Acceptance, and meet stringent standards for safety and sustainability. Our products are also certified Microbiome Friendly by MyMicrobiome.
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Clinically tested, next-generation formulas that treat the bacteria behind flare-ups to visibly transform skin.