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PRECISION HEALING SPRAY
4.6
Rated 4.6 out of 5 stars
4.6
#size_standard size 200ml
4.6
Rated 4.6 out of 5 stars
4.6
#size_standard size 80ml
4.4
Rated 4.4 out of 5 stars
4.4
ECZEMA PRECISION KIT
4.8
Rated 4.8 out of 5 stars
4.8

PRECISION HEALING SPRAY

Soothes flare-ups + calms eczema-prone skin

4.6
Rated 4.6 out of 5 stars
4.6

This easy-to-use spray provides immediate & long-term relief for flare-ups in eczema-prone skin. Made with soothing allantoin and our patented TPZ-01™ enzyme to target and kill eczema-associated Staph aureus bacteria, this convenient spray can be applied to face, body, and hard-to-reach areas whenever irritated skin needs quick calming.

Details

Backed by independent testing and some of the most rigorous certifications in skincare, our formulas represent a new standard in safe, effective eczema care.

Dermatologist Approved
Safe for Eye Area
NEA Accepted
Hypoallergenic
Steroid Free
Certified Microbiome Friendly
Fragrance Free
Ingredients

TPZ-01™ Enzyme 
Our patented TPZ-01™ enzyme selectively targets and kills 99.99% of eczema-associated Staph aureus bacteria within 5 minutes while preserving beneficial microorganisms.

0.5% Allantoin
This multifunctional skin protectant soothes and relieves irritation and flare-ups.

Betaine
Naturally derived from beets, betaine provides long-term hydration & protects against future irritation.

Pro-Vitamin B5 + Sorbitol
Two potent moisture magnets that hydrate, comfort, and help replenish the skin barrier.

Full Ingredient List
Active Ingredient: 0.5% Allantoin
Inactive Ingredients:
Water/Aqua/Eau, Betaine, Sorbitol, Arginine HCl, Hydroxyethylpiperazine Ethane Sulfonic Acid, Panthenol, Sodium Chloride, Methionine, Calcium Chloride, Methylparaben, Sodium Hydroxide, Acetyl Cysteine, Hydrochloric Acid, sr-(Staphylococcus sp. Polypeptide-1 Dipeptide-81 Streptococcus Suis Phage Polypeptide-1 Dipeptide-19 Hexapeptide-40), Hydroxypropyl Methylcellulose

How To Use

Apply to eczema-prone skin at least twice a day. Spray onto face and body throughout the day to keep Staph aureus bacteria in check. Use as a standalone soothing treatment, or use in conjunction with the Eczema Precision Hydrogel for a double dose of our patented TPZ-01™ enzyme. Follow with Eczema Therapy Cream to lock in moisture.

KEY INGREDIENTS

0.5% Allantoin

This multifunctional skin protectant soothes and relieves irritation 
and flare-ups.

Betaine

Naturally derived from beets, betaine provides long-term hydration & protects against future irritation.

Pro-Vitamin B5 + Sorbitol

Two potent moisture magnets that hydrate, comfort, and help replenish the skin barrier.

KEY INGREDIENTS

0.5% Allantoin

This multifunctional skin protectant soothes and relieves irritation 
and flare-ups.

Betaine

Naturally derived from beets, betaine provides long-term hydration & protects against future irritation.

Pro-Vitamin B5 + Sorbitol

Two potent moisture magnets that hydrate, comfort, and help replenish the skin barrier.

MEET TPZ-01™

 99.99% of S. aureus bacteria killed within 5 minutes*

In a breakthrough for eczema care, our patented TPZ-01™ enzyme strategically zeroes in on eczema-associated Staph aureus bacteria, leaving the rest of the microbiome balanced for a stronger, more resilient skin barrier.

*Based on in vitro data of TPZ-01™ enzyme

MEET TPZ-01™

99.99% of Staph aureus bacteria killed within 5 minutes*

In a breakthrough for eczema care, our patented TPZ-01™ enzyme strategically zeroes in on eczema-associated Staph aureus bacteria, leaving the rest of the microbiome balanced for a stronger, more resilient skin barrier.

*Based on in vitro data of TPZ-01™ enzyme

Clinically Proven to Restore the Skin Barrier

100%

of participants saw immediate improvement in skin barrier function that lasted all day*

97%

experienced instant improvement in hydration**

95%

agreed the spray is non-irritating and gentle on skin**

*Based on a clinical trial of 33 adults with damaged skin barriers.
**Based on a 7-day clinical study of 34 adults with dry skin.

erin s.

Within 1–2 days my inflammation is way down, 
and in less than a week it is almost gone...It really has worked better than anything that I have tried.

Bryana B

Where has this been my whole life? This formula is incredible and truly helped my eczema skin so much. …a spray product is something I have never tried for my eczema and now I don't think I can ever go back.

Smart Science, By Design

COLLOIDAL
OATMEAL
BLEACH
BATHS
STEROID
CREAMS
PRESCRIPTION
DRUGS
Treats eczema symptoms
Targets eczema-associated S. aureus
Preserves the skin’s beneficial microbiome
Patented technology
No side effects
*data on file

FAQS

How is this different from other eczema treatments?

​​Studies show that people with eczema have much higher levels of a bacteria called Staphylococcus aureus on their skin, particularly during flare-ups.  Once on the skin, Staphylococcus aureus—also known as Staph, Staph aureus, or S. aureus—can secrete toxins that damage the skin barrier, increase itching, and activate the immune system. The more Staph aureus on skin, the more severe the eczema symptoms—yet standard eczema treatments like moisturizers and steroid creams do not address this underlying imbalance in the eczema skin microbiome.

At Hypothesis, we’re using the science of biotechnology to develop clinically validated skincare that tackles the eczema microbiome head on. Our patented TPZ-01™ precision enzyme targets and kills eczema-associated Staph aureus bacteria while preserving the rest of your skin’s helpful microbiome, helping to reestablish a healthy, balanced microbiome that breaks the cycle of itching, skin barrier damage, and flare-ups.

Does the Precision Healing Spray contain steroids?

All Hypothesis products are both steroid-free and fragrance-free. We avoid known irritants in our formulas and use rigorously screened, cutting-edge ingredients with proven track records of both gentleness and efficacy. Our clinically tested formulas are dermatologist-approved, accepted by the National Eczema Association (NEA), certified Microbiome Friendly by MyMicrobiome, safe for use in the delicate eye area, and hypoallergenic.

Does the Precision Healing Spray contain fragrance?

The Precision Healing Spray is fragrance-free. We avoid known irritants in our formulas and use rigorously screened, cutting-edge ingredients with proven track records of both gentleness and efficacy. You may notice a mild, naturally-occurring scent from the amino acid methionine. Methionine is an antioxidant that helps maintain the stability of our patented TPZ-01™ enzyme while protecting the skin from free radicals and supporting the skin barrier. Rather than covering this natural scent with potentially irritating synthetic fragrances or chemical masking agents, we choose to keep our formula as streamlined as possible to minimize irritation. Methionine's scent is completely normal and should quickly fade as the formula absorbs into your skin.

Where can I apply the Precision Healing Spray? 

The Precision Healing Spray can be applied anywhere externally on your face or body where you’re experiencing eczema symptoms, including eyelids. The convenient spray format is particularly good for quick soothing in hard to reach areas like the scalp and back. As with all our products, this formula is safe for use in the delicate eye area, dermatologist approved, and accepted by the National Eczema Association (NEA). We recommend applying liberally to itchy, irritated, or dry skin, or anywhere you typically have eczema flare-ups.

As with all new skincare products, we recommend doing a patch test before first use, especially if you have very sensitive skin or known allergies. Apply a small amount to an area like the inside of your wrist or behind your ear, wait 24 hours, and check for any reaction before applying to larger areas or your face.

How do I use Hypothesis products in my daily routine?

Our Precision Healing Spray with TPZ-01™ is a convenient spray format designed for quick application to hard-to-reach areas or on-the-go use throughout the day. It can be used as a standalone soothing spray, or used in conjunction with our Eczema Precision Hydrogel for a double dose of the TPZ-01™ enzyme. Our Eczema Therapy Cream is a moisturizer designed to work in tandem with the TPZ-01™ enzyme, and can be used after the Precision Healing Spray or Eczema Precision Hydrogel to seal in additional moisture. Apply the Eczema Therapy Cream any time your skin needs immediate hydration or skin barrier repair.

How long does it take to see results?

In clinical studies, users experienced instant relief of dry, cracked skin immediately after using the Precision Healing Spray, and 97% saw improved hydration within 30 minutes. Most users saw additional improvement in flare-ups and irritation within a week, with best results after 2–4 weeks of twice-daily use.

Is the Precision Healing Spray safe for babies and children?

Yes, all of our hypoallergenic, dermatologist-approved formulas are extensively tested by independent certifying organizations to meet the highest standards for safety and gentleness on sensitive skin. Our formulas are steroid-free and fragrance-free, have received the National Eczema Association (NEA) Seal of Acceptance, and meet stringent standards for safety and sustainability. Our products are also certified Microbiome Friendly by MyMicrobiome.

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93%would recommend this product
4.6
Rated 4.6 out of 5 stars
Based on 30 reviews
Total 5 star reviews: 19 Total 4 star reviews: 9 Total 3 star reviews: 2 Total 2 star reviews: 0 Total 1 star reviews: 0
30 reviews
  • SN
    Sophia N.
    Verified Buyer
    I recommend this product
    What are your skin challenges? Eczema, Redness, Itchiness, Dryness, Texture
    What is your primary area of concern? Hands, Legs, Arms, Trunk
    What did you like about the product? Visible results, Soothing relief, Itch relief, Barrier repair, Everyday use
    Rated 5 out of 5 stars
    1 week ago
    Magic in a Bottle

    I had this angry red patch on my hand for about 3 months. The doctors prescribed me antibiotics, steroid creams, etc. and nothing worked. I developed these patches all over my body, and the doctors kept insisting that steroid creams were the best/only way to heal my eczema. I ordered Hypothesis immediately as a last ditch effort and was shocked by the results. After using the gel, spray, and cream on my hand, my patch was cleared up in a week and a half. The spot is almost completely gone and my skin is so close to feeling like it used to. After using my hand as a test patch and having no reaction, I’ve started using this all over my body and am still amazed by the results! Couldn’t recommend this more. (Before and After Pictures for Proof!!)

  • HE
    Helen E.
    I recommend this product
    What are your skin challenges? Eczema
    What is your primary area of concern? Hands, Neck
    What did you like about the product? Itch relief, Hydrating, Everyday use, Gentle formula
    Rated 5 out of 5 stars
    2 weeks ago
    Spray away the flares

    The spray had me at first spritz, instant relief & it calmed my skin.

  • NS
    Natalyn S.
    I recommend this product
    What are your skin challenges? Eczema, Redness, Itchiness, Skin thickening, Dryness
    What is your primary area of concern? Face, Neck, Legs, Arms
    What did you like about the product? Hydrating, Everyday use
    Rated 5 out of 5 stars
    4 weeks ago
    Great for quick on the go

    Out of all the three products I was sent my favorite one had to be the spray I like to put it before and to seal my moisture after . I found that this product works best for me in the car. When I’m blasting the cold a/c air in my face, it helps cooled down that sensation and makes my face feel hydrated!!

  • MM
    Marybeth M.
    I recommend this product
    What are your skin challenges? Redness, Itchiness, Skin thickening, Dryness
    What is your primary area of concern? Hands, Neck, Legs, Arms
    What did you like about the product? Soothing relief, Itch relief, Everyday use
    Rated 5 out of 5 stars
    1 month ago
    Relief

    I love this product so much!!! When I felt like I needed to scratch and itch all I had to do was spray it and the I didn’t feel the need to scratch anymore. This relief allowed for me to not break skin as I wasn’t scratching and my scars were lightening.

  • CM
    Chelsea M.
    I recommend this product
    What did you like about the product? Hydrating
    Rated 4 out of 5 stars
    1 month ago
    Hypochlorous Acid Alternative

    My favorite thing about this product was the spritzer. It sprays so gently and comes out nicely. There is a slight scent to it like the hydrogel, but it’s tolerable. I asked my family how they felt about it and they were fine. It didn’t bother them.