Skip to content

Cart(0)

Your cart is empty.

Continue shopping

Popular searches

Featured products

PRECISION HEALING SPRAY
4.4
Rated 4.4 out of 5 stars
4.4
#size_standard size 200ml
4.6
Rated 4.6 out of 5 stars
4.6
#size_standard size 80ml
4.4
Rated 4.4 out of 5 stars
4.4
ECZEMA PRECISION KIT
4.7
Rated 4.7 out of 5 stars
4.7

PRECISION HEALING SPRAY

Soothes flare-ups + calms eczema-prone skin

4.4
Rated 4.4 out of 5 stars
4.4

This easy-to-use spray provides immediate & long-term relief for flare-ups in eczema-prone skin. Made with soothing allantoin and our patented TPZ-01™ enzyme to target and kill eczema-associated Staph aureus bacteria, this convenient spray can be applied to face, body, and hard-to-reach areas whenever irritated skin needs quick calming.

Details

Backed by independent testing and some of the most rigorous certifications in skincare, our formulas represent a new standard in safe, effective eczema care.

Dermatologist Approved
Safe for Eye Area
NEA Accepted
Hypoallergenic
Steroid Free
Certified Microbiome Friendly
Fragrance Free
Ingredients

TPZ-01™ Enzyme 
Our patented TPZ-01™ enzyme selectively targets and kills 99.99% of eczema-associated Staph aureus bacteria within 5 minutes while preserving beneficial microorganisms.

0.5% Allantoin
This multifunctional skin protectant soothes and relieves irritation and flare-ups.

Betaine
Naturally derived from beets, betaine provides long-term hydration & protects against future irritation.

Pro-Vitamin B5 + Sorbitol
Two potent moisture magnets that hydrate, comfort, and help replenish the skin barrier.

Full Ingredient List
Active Ingredient: 0.5% Allantoin
Inactive Ingredients:
Water/Aqua/Eau, Betaine, Sorbitol, Arginine HCl, Hydroxyethylpiperazine Ethane Sulfonic Acid, Panthenol, Sodium Chloride, Methionine, Calcium Chloride, Methylparaben, Sodium Hydroxide, Acetyl Cysteine, Hydrochloric Acid, sr-(Staphylococcus sp. Polypeptide-1 Dipeptide-81 Streptococcus Suis Phage Polypeptide-1 Dipeptide-19 Hexapeptide-40), Hydroxypropyl Methylcellulose

How To Use

Apply to eczema-prone skin at least twice a day. Spray onto face and body throughout the day to keep Staph aureus bacteria in check. Use as a standalone soothing treatment, or use in conjunction with the Eczema Precision Hydrogel for a double dose of our patented TPZ-01™ enzyme. Follow with Eczema Therapy Cream to lock in moisture.

KEY INGREDIENTS

0.5% Allantoin

This multifunctional skin protectant soothes and relieves irritation 
and flare-ups.

Betaine

Naturally derived from beets, betaine provides long-term hydration & protects against future irritation.

Pro-Vitamin B5 + Sorbitol

Two potent moisture magnets that hydrate, comfort, and help replenish the skin barrier.

KEY INGREDIENTS

0.5% Allantoin

This multifunctional skin protectant soothes and relieves irritation 
and flare-ups.

Betaine

Naturally derived from beets, betaine provides long-term hydration & protects against future irritation.

Pro-Vitamin B5 + Sorbitol

Two potent moisture magnets that hydrate, comfort, and help replenish the skin barrier.

MEET TPZ-01™

 99.99% of S. aureus bacteria killed within 5 minutes*

In a breakthrough for eczema care, our patented TPZ-01™ enzyme strategically zeroes in on eczema-associated Staph aureus bacteria, leaving the rest of the microbiome balanced for a stronger, more resilient skin barrier.

*Based on in vitro data of TPZ-01™ enzyme

MEET TPZ-01™

99.99% of Staph aureus bacteria killed within 5 minutes*

In a breakthrough for eczema care, our patented TPZ-01™ enzyme strategically zeroes in on eczema-associated Staph aureus bacteria, leaving the rest of the microbiome balanced for a stronger, more resilient skin barrier.

*Based on in vitro data of TPZ-01™ enzyme

Clinically Proven to Restore the Skin Barrier

100%

of participants saw immediate improvement in skin barrier function that lasted all day*

97%

experienced instant improvement in hydration**

95%

agreed the spray is non-irritating and gentle on skin**

*Based on a clinical trial of 33 adults with damaged skin barriers.
**Based on a 7-day clinical study of 34 adults with dry skin.

erin s.

Within 1–2 days my inflammation is way down, 
and in less than a week it is almost gone...It really has worked better than anything that I have tried.

Bryana B

Where has this been my whole life? This formula is incredible and truly helped my eczema skin so much. …a spray product is something I have never tried for my eczema and now I don't think I can ever go back.

Smart Science, By Design

FAQS

How is this different from other eczema treatments?

​​Studies show that people with eczema have much higher levels of a bacteria called Staphylococcus aureus on their skin, particularly during flare-ups.  Once on the skin, Staphylococcus aureus—also known as Staph, Staph aureus, or S. aureus—can secrete toxins that damage the skin barrier, increase itching, and activate the immune system. The more Staph aureus on skin, the more severe the eczema symptoms—yet standard eczema treatments like moisturizers and steroid creams do not address this underlying imbalance in the eczema skin microbiome.

At Hypothesis, we’re using the science of biotechnology to develop clinically validated skincare that tackles the eczema microbiome head on. Our patented TPZ-01™ precision enzyme targets and kills eczema-associated Staph aureus bacteria while preserving the rest of your skin’s helpful microbiome, helping to reestablish a healthy, balanced microbiome that breaks the cycle of itching, skin barrier damage, and flare-ups.

Does the Precision Healing Spray contain steroids?

All Hypothesis products are both steroid-free and fragrance-free. We avoid known irritants in our formulas and use rigorously screened, cutting-edge ingredients with proven track records of both gentleness and efficacy. Our clinically tested formulas are dermatologist-approved, accepted by the National Eczema Association (NEA), certified Microbiome Friendly by MyMicrobiome, safe for use in the delicate eye area, and hypoallergenic.

Does the Precision Healing Spray contain fragrance?

The Precision Healing Spray is fragrance-free. We avoid known irritants in our formulas and use rigorously screened, cutting-edge ingredients with proven track records of both gentleness and efficacy. You may notice a mild, naturally-occurring scent from the amino acid methionine. Methionine is an antioxidant that helps maintain the stability of our patented TPZ-01™ enzyme while protecting the skin from free radicals and supporting the skin barrier. Rather than covering this natural scent with potentially irritating synthetic fragrances or chemical masking agents, we choose to keep our formula as streamlined as possible to minimize irritation. Methionine's scent is completely normal and should quickly fade as the formula absorbs into your skin.

Where can I apply the Precision Healing Spray? 

The Precision Healing Spray can be applied anywhere externally on your face or body where you’re experiencing eczema symptoms, including eyelids. The convenient spray format is particularly good for quick soothing in hard to reach areas like the scalp and back. As with all our products, this formula is safe for use in the delicate eye area, dermatologist approved, and accepted by the National Eczema Association (NEA). We recommend applying liberally to itchy, irritated, or dry skin, or anywhere you typically have eczema flare-ups.

As with all new skincare products, we recommend doing a patch test before first use, especially if you have very sensitive skin or known allergies. Apply a small amount to an area like the inside of your wrist or behind your ear, wait 24 hours, and check for any reaction before applying to larger areas or your face.

How do I use Hypothesis products in my daily routine?

Our Precision Healing Spray with TPZ-01™ is a convenient spray format designed for quick application to hard-to-reach areas or on-the-go use throughout the day. It can be used as a standalone soothing spray, or used in conjunction with our Eczema Precision Hydrogel for a double dose of the TPZ-01™ enzyme. Our Eczema Therapy Cream is a moisturizer designed to work in tandem with the TPZ-01™ enzyme, and can be used after the Precision Healing Spray or Eczema Precision Hydrogel to seal in additional moisture. Apply the Eczema Therapy Cream any time your skin needs immediate hydration or skin barrier repair.

How long does it take to see results?

In clinical studies, users experienced instant relief of dry, cracked skin immediately after using the Precision Healing Spray, and 97% saw improved hydration within 30 minutes. Most users saw additional improvement in flare-ups and irritation within a week, with best results after 2–4 weeks of twice-daily use.

Is the Precision Healing Spray safe for babies and children?

Yes, all of our hypoallergenic, dermatologist-approved formulas are extensively tested by independent certifying organizations to meet the highest standards for safety and gentleness on sensitive skin. Our formulas are steroid-free and fragrance-free, have received the National Eczema Association (NEA) Seal of Acceptance, and meet stringent standards for safety and sustainability. Our products are also certified Microbiome Friendly by MyMicrobiome.

Header

Use this content to share information about your store and products.

93%would recommend this product
4.4
Rated 4.4 out of 5 stars
Based on 14 reviews
Total 5 star reviews: 7 Total 4 star reviews: 6 Total 3 star reviews: 1 Total 2 star reviews: 0 Total 1 star reviews: 0
14 reviews
  • B
    Beyoncec_21
    Verified Reviewer
    I recommend this product
    What are your skin challenges? Eczema, Itchiness, Redness, Dryness, Skin thickening
    What is your primary area of concern? Face, Legs, Hands, Arms, Trunk
    What did you like about the product? Microbiome friendly, Hydrating, Gentle formula, Everyday use, Visible results
    Rated 5 out of 5 stars
    Yesterday
    Highly recommended

    I just started this new product about a week ago and I already am see drastic improvements. My skin is so glowy and NO MORE FLAKES! I love how this spray is super easy and effective to use especially if busy at work and need a quickly pick me up. I’ve been using this spray the hydrogel and the cream all together and it’s doing wonders

  • KR
    Karen R.
    What are your skin challenges? Eczema
    What is your primary area of concern? Arms
    What did you like about the product? Fast absorbing
    Rated 3 out of 5 stars
    2 weeks ago
    Feels nice going on

    It felt nice going on. I was hoping for visible results an will keep trying. Possibly slight improvement

  • BB
    Bryana B.
    I recommend this product
    What are your skin challenges? Eczema, Redness, Itchiness, Skin thickening, Dryness
    What is your primary area of concern? Face, Hands, Legs, Arms, Trunk
    What did you like about the product? Soothing relief, Everyday use, Fast absorbing
    Rated 5 out of 5 stars
    2 weeks ago
    Where has this been my whole life?

    I am obsessed with this stuff, seriously. This formula is incredible and truly helped my eczema skin so much. It also helped me to realize that staph aureus was definitely playing a role in my flares. Beyond that, a spray product is something I have never tried for my eczema and now I don't think I can ever go back. Especially for folks with widespread flares like myself, a spray is easier to apply and also brings some much needed cooling relief. when flares are irritated. Would absolutely recommend!

  • OW
    Oliver W.
    I recommend this product
    What are your skin challenges? Eczema, Redness, Itchiness, Dryness
    What is your primary area of concern? Legs, Arms
    What did you like about the product? Redness reduction
    Rated 5 out of 5 stars
    2 weeks ago
    Eczema spray review

    It worked really well, thank you! The pictures don't really show much change, but the skin is much better to the touch and itchiness is completely gone. We will keep using it as the winter and dry air come.

  • JP
    Jeremy P.
    I recommend this product
    What are your skin challenges? Eczema, Redness, Itchiness, Skin thickening, Dryness
    What is your primary area of concern? Face, Neck, Legs, Arms
    What did you like about the product? Soothing relief, Itch relief, Microbiome friendly, Everyday use, Fast absorbing
    Rated 4 out of 5 stars
    4 weeks ago
    Spray

    I liked the spray. It's easier to use than the gel for behind my knees, inside of my elbows, back of my neck though I'm careful on my neck not to get it into my eyes. It does have that same bad smell as the gel I like to put it in the fridge so it's cold when I use it. that helps to calm my skin and make it feel better