Free Back-to-School Gift
WITH ORDERS $60+
Spend $60 and receive four of our favorite back-to-school picks, on us: Hypothesis™ Precision Microdart Blemish Patches, Well People Expressionist Curling Mascara Mini, Make It Skin Superband bandages, and Kind Laundry Detergent Sheets.*
*Offer valid while supplies last. No code required. Limit one gift per order.
You've tried stronger skincare.
It's time to try smarter.
First-of-their-kind precision enzymes that selectively target the bacteria driving your acne breakouts and eczema flare-ups.
Free Back-to-School Gift
WITH ORDERS $60+
Spend $60 and receive four of our favorite back-to-school picks, on us: Hypothesis™ Precision Microdart Blemish Patches, Well People Expressionist Curling Mascara Mini, Make It Skin Superband bandages, and Kind Laundry Detergent Sheets.*
*Offer valid while supplies last. No code required. Limit one gift per order.
85%
reduction in Staph aureus on the skin*
2.5x
more effective than a standard eczema treatment*
97%
saw fewer breakouts**
81%
reduction in
inflamed pimples**
*Based on a clinical trial of 24 adults with moderate to severe eczema comparing hypothesis™ to a product containing over-the-counter levels of colloidal oatmeal
**Based on a clinical trial of 32 adults with mild to severe acne
Real People, Real Results
I knew I had a staph problem on my skin…I noticed improvements after the first couple of uses and within a few weeks the flaking is now very minimal. I’m pretty mind blown…10/10 can’t recommend this enough.
DARCI
I loved these products for treating my acne. I think I’ve improved by about 70–80%, which has pleasantly surprised me since I had tried several products before and none of them worked for me!! ✨
JULIETH
My 6-year old has struggled with eczema since he was a baby…To say the results were incredible is an understatement. Within just a couple of weeks, his red, itchy skin completely returned to normal.
CHRISTA
One use actually lowered my inflammation and irritation! I feel like overnight the microdarts helped to lower the overall redness and appearance, and they stayed on pretty well. I did not feel them while I was sleeping, and they were easy to apply as well as take off. Would recommend!
HAILEY
Within 1 to 2 days my inflammation is way down, and in less than a week it is almost gone…It really has worked better than anything that I have tried.
ERIN
I've been struggling with acne for a really long time, so I'm always careful with trying new skincare. But I honestly loved these products. My inflamed breakouts disappeared and I didn't really get new ones during that time. Overall, my skin looks calmer and healthier now.
MARYNA
I LOVE that I can use it on my child repeatedly, for as long as needed…I didn’t have to be concerned about how long she was using it, like I do with topical steroids, and the fact that IT WORKED made both of us feel better.
KIM
I can't believe how much these blemish patches reduced the irritation, redness and even pain of my acne. I get hormonal acne during that time of the month and these have been a lifesaver. They didn't budge through the night, are easy to apply & take off, plus definitely reduced my urge to pick at my skin.
BRIANA
Two conditions. Two precision solutions.
The Hypothesis Difference
Traditional eczema and acne care either ignore the specific bacteria driving flares and breakouts—or wipe out all bacteria, including the good ones your skin needs.
We believed there was a smarter way. So we built it. Three years of NIH-supported research. Two awarded patents. The result: TPZ-01™ and CUT-02™, the first precision enzymes to target only the bad bacteria.
In the Blog
Acne isn't caused by too much bacteria—it's caused by the wrong kind dominating your skin’s microbiome. Learn why precisely targeting C. acnes changes everything.
New research shows the eczema microbiome plays a key role in flares. Learn how Staph aureus drives atopic dermatitis, and why standard treatments often fall short.
Three different approaches to managing the bacterial driver of eczema flares, and understanding what each one does to your skin's microbiome.