Complete Acne Care Set

Name: Complete Acne Care Set
Brand: Hypothesis Bio
SKU: 20014
Price: 129.99 USD
Availability: InStock

A full precision acne regimen for clear, balanced skin

4.7

Rated 4.7 out of 5 stars

4.7

Everything that acne-prone skin needs in one complete collection: Daily Acne Cleanser purifies without stripping, Acne Precision Serum targets acne-causing bacteria with our patented CUT-02™ enzyme, Balancing + Brightening Gel Cream restores the barrier, Precision Microdart Blemish Patches stop early-stage pimples before they surface, and Precision Clarifying Spray with CUT-02™ delivers on-the-go bacterial control. Our first-of-its-kind system is clinically proven to clear breakouts without harsh side effects.

Complete Acne Routine includes:

Daily Acne Cleanser 180mL
Acne Precision Serum 50mL
Balancing + Brightening Gel Cream 50mL
Precision Microdart Blemish Patches (9 count)
Precision Clarifying Spray 50mL

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Benefits

Specifically targets acne-causing C. acnes bacteria while preserving the microbiome
Reduces acne breakouts and redness
Non-stripping cleanser exfoliates clogged pores and purifies skin
Weightless gel cream hydrates, evens skin tone, and visibly brightens
Dissolving microdarts stop early-stage pimples before they fully develop
Convenient spray delivers precision bacterial control to hard-to-reach areas
Helps prevent new acne blemishes from forming
Minimizes the appearance of pores and comedones
Restores the skin's protective microbiome
Formulated for all acne types, including cystic and hormonal breakouts

Safe for Sensitive Skin

Dermatologist Approved

Hypoallergenic

Non-comedogenic

Safe for Eye Area

No Added

Oils
Phthalates
Dyes
Drying alcohols
Sulfates
Benzoyl peroxide
Fragrance

Ingredients

CUT-02™ Enzyme
A patented first-of-its-kind precision enzyme that selectively targets acne-causing C. acnes bacteria while preserving the skin's beneficial microbiome.

Salicylic Acid
An FDA-approved acne-fighting ingredient that gently exfoliates inside the pore to dissolve excess oil and dead skin cells, helping to clear breakouts and prevent new ones from forming.

Pro-Vitamin B5
This moisture-attracting ingredient reduces visible redness, adds weightless hydration, and helps replenish the skin barrier.

Centella Asiatica
Rich in antioxidants, centella helps to calm irritation and strengthen the skin's naturally protective barrier.

Tea Tree Oil
Derived from the tea tree plant, this ingredient features antioxidant, antibacterial, and anti-inflammatory properties to purify and help calm inflamed skin.

Hyaluronic Acid
This gentle but powerful humectant attracts weightless moisture to the skin to restore balance.

Niacinamide
A form of Vitamin B3, niacinamide helps visibly reduce post-blemish marks and minimize the appearance of pores.

Licorice Extract
Derived from the licorice plant root, this brightening extract helps visibly fade post-acne discoloration.

Azelaic Acid Derivative
A multitasking ingredient that helps regulate excess oil production, calm irritation, and even skin tone.

Allantoin
A multifunctional skin protectant that soothes and relieves irritation in breakout-prone skin.

Full Ingredient List

Acne Precision Serum
Active Ingredient: Salicylic Acid 0.5%
Inactive Ingredients: Water/Aqua/Eau, Betaine, Methylpropanediol, Glycerin, Panthenol, Hydroxyethylpiperazine Ethane Sulfonic Acid, Sodium Chloride, Arginine HCl, Methionine, Hydroxypropyl Methylcellulose, Centella Asiatica Herb Extract, Caprylhydroxamic Acid, 1,2-Hexanediol, Propanediol, Sodium Hydroxide, Hydrochloric Acid, sr-(Caudoviricetes Polypeptide-1 Depeptide-81 Cutibacterium Acnes Polypeptide-1 Pentapeptide-124 Dipeptide-19 Hexapeptide-40)

Daily Acne Cleanser
Active Ingredient: Salicylic Acid 1%
Inactive Ingredients: Water/Aqua/Eau, Aloe Barbadensis Leaf Juice, Cocamidopropyl Hydroxysultaine, Glycerin, Sodium C14-16 Olefin Sulfonate, Sodium Laurylglucosides Hydroxypropylsulfonate, Sodium Methyl Cocoyl Taurate, Glycolic Acid, Gluconolactone, Zinc PCA, Sorbitan Oleate Decylglucoside Crosspolymer, Melaleuca Alternifolia (Tea Tree) Leaf Oil, Tetrasodium Glutamate Diacetate, Sodium Benzoate, Sodium Hydroxide, Sodium Chloride, Coconut Acid, Calcium Gluconate

Balancing + Brightening Gel Cream
Ingredients: Water, Glycerin, Propanediol, Dicaprylyl Ether, Niacinamide, Polyglycerin-3, Potassium Azeloyl Diglycinate, Polyglyceryl-3 Distearate, Sodium Carbomer, Squalane, Cetyl Alcohol, Dimethicone, Glyceryl Stearate Citrate, Dipotassium Glycyrrhizate, C9-12 Alkane, Polysilicone-11, Sodium Hyaluronate, Caprylhydroxamic Acid, 1,2-Hexanediol, Polyacrylate-13, Polyisobutene, Polysorbate 20, Sorbitan Isostearate, Tocopherol

Precision Microdart Blemish Patches
Ingredients: Hyaluronic Acid, Centella Asiatica Extract, Amino Acids, sr-(Caudoviricetes Polypeptide-1 Depeptide-81 Cutibacterium Acnes Polypeptide-1 Pentapeptide-124 Dipeptide-19 Hexapeptide-40)

Precision Clarifying Spray
Ingredients: Water/Aqua/Eau, Betaine, Aloe Barbadensis Leaf Juice, Allantoin, sr-(Caudoviricetes Polypeptide-1 Depeptide-81 Cutibacterium Acnes Polypeptide-1 Pentapeptide-124 Dipeptide-19 Hexapeptide-40), Caprylhydroxamic Acid, 1,2-Hexanediol, Propanediol, Hydroxyethylpiperazine Ethane Sulfonic Acid, Sodium Chloride, Arginine HCl, Methionine, Sodium Hydroxide, Hydrochloric Acid

How To Use

Start with a once-daily application in the evening. Cleanse with Daily Acne Cleanser, then apply Acne Precision Serum and let it fully absorb. Finish with Balancing + Brightening Gel Cream for weightless hydration. Increase to twice daily (morning and evening) if well-tolerated. Apply Precision Clarifying Spray as needed throughout the day to instantly calm skin and keep C. acnes bacteria in check. Apply Precision Microdart Blemish Patches as needed to clean, dry skin to address early, under-the-surface pimples.

Note: As products with salicylic acid can increase your skin's sun sensitivity, use an SPF during the day.

Acne Care Reimagined. Powered by CUT-02™.

YOUR DAILY ROUTINE

Use morning and night to treat and prevent acne.

WHEN SKIN NEEDS IT

Apply anytime to restore skin to its balanced state.

Cleanse

Clear clogged pores and gently purify with Daily Acne Cleanser

Shop Cleanser

Treat

Target acne-causing C. acnes bacteria with Acne Precision Serum

Shop Serum

Hydrate

Rebuild the protective barrier with Balancing + Brightening Gel Cream

Shop Cream

Spot Treat

Stop early-stage pimples with Microdart Blemish Patches

Shop Patches

Spray

Control bacteria and soothe skin on the go with Precision Clarifying Spray

Shop Spray

Real People, Real Results

Smart Science, By Design

	Benzoyl Peroxide	Antibiotics	Accutane
Specifically targets acne bacteria
Supports the microbiome
Low risk of skin irritation	Dryness, peeling, redness	Irritation + rashes	Severe dryness
No other side effects	Possible benzene exposure	Antibiotic resistance	Significant potential side effects
Safe for long-term use	Limited by irritation

*data on file

FAQS

What's included in the Complete Acne Care Set?

The Complete Acne Care System includes Daily Acne Cleanser (180mL), Acne Precision Serum (50mL), Balancing + Brightening Gel Cream (50mL), Precision Microdart Blemish Patches (9 count), and Precision Clarifying Spray (50mL)—everything you need for a complete precision acne care regimen.

How is the Complete Acne Care Set different from conventional acne treatments?

Most acne treatments target all bacteria, disrupting your skin's microbiome and causing harsh side effects like dryness and irritation. The 5-part Complete Acne Care Set is built around the patented CUT-02™ enzyme, which selectively targets only acne-causing C. acnes bacteria while preserving your skin's beneficial microbiome. The result is effective acne care gentle enough for daily use.

How long does it take to see results?

You should typically start to see improvements within one to two weeks, with the most substantial results building over the full 8 weeks. In our clinical trial, 97% of participants reported fewer breakouts and saw an 81% reduction in inflamed pimples. 95% experienced no irritation over 8 weeks of daily use. Consistent daily use is key—it takes time for the microbiome to rebalance and inflammation to calm.

Does this acne care set contain fragrance?

None of the products in the Complete Acne Care Set contain added fragrances. You may notice a faint natural aroma from our active and therapeutic ingredients, particularly the amino acid methionine in the Acne Precision Serum and Precision Clarifying Spray and the tea tree oil in our Daily Acne Cleanser. We choose not to add unnecessary ingredients to mask our formulas' natural aromas.

Is this acne care set safe for sensitive skin?

Yes. All five products are dermatologist approved, hypoallergenic, non-comedogenic, and safe for sensitive skin and the eye area. Our precision approach targets only acne-causing bacteria, meaning fewer harsh side effects than conventional treatments.

Note: The Daily Acne Cleanser and Acne Precision Serum contain salicylic acid. As products with salicylic acid can increase your skin’s sun sensitivity, use an SPF during the day.

How is the Complete Acne Care Set different from the 3-Step Precision Acne Routine?

Our 3-Step Precision Acne Routine covers your essential daily regimen: cleanse, treat, and restore. The 5-part Complete Acne Care Set adds two precision essentials made with our patented CUT-02™enzyme for clear, balanced skin: Precision Microdart Blemish Patches for early-stage pimple control, and Precision Clarifying Spray for on-the-go targeted bacterial control and soothing throughout the day.

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96%would recommend these products

4.7

Rated 4.7 out of 5 stars

Based on 102 reviews

Reviews Summary

Customers say this acne system feels lightweight and hydrating without heaviness or greasiness. The cleanser gently removes impurities while leaving skin soft and balanced, and the serum absorbs quickly without irritation. Many reviews highlight visible improvements in breakouts and redness within days to weeks, with users appreciating that these products work effectively without over-drying sensitive skin. The patches stay on well and noticeably reduce blemish size and redness overnight. Common feedback notes a strong herbal or unusual scent, though most find results outweigh this minor concern. Users report smoother skin texture, fewer breakouts, and faster healing of existing blemishes.

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102 reviews

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AW
Ashley W.
Verified Buyer
Reviewing
Acne Precision Serum
I recommend this product
What is your skin type? Combination, Acne-Prone, Sensitive
What are your skin challenges? Pimples
What did you like about the product? Visible results, Non-drying, Easy to apply, Lightweight
Rated 4 out of 5 stars
3 weeks ago
Really working for my skin!
I’ve had a noticeable decrease in breakouts since using.
Was this helpful?
JD
Joanne D.
Verified Buyer
Reviewing
Balancing + Brightening Gel Cream
I recommend this product
What is your skin type? Oily
What are your skin challenges? Pimples, Hyperpigmentation
What did you like about the product? Hydrating
Rated 5 out of 5 stars
4 weeks ago
Very creamy and soothing
Didn't break me out and helped moisturize my face well
Was this helpful?
KD
Katherine D.
Verified Buyer
Reviewing
Balancing + Brightening Gel Cream
I recommend this product
What is your skin type? Dry, Sensitive
What are your skin challenges? Redness
What did you like about the product? Everyday Use, Hydrating, Lightweight, Visible Results, Gentle Formula
Rated 5 out of 5 stars
2 months ago
Balancing and brightening gel cream
This product clears and moisturizes my skin. It also takes the redness away.
Was this helpful?
BD
Brie D. V.
Reviewing
Balancing + Brightening Gel Cream
I recommend this product
What is your skin type? Combination
What are your skin challenges? Whiteheads, Blackheads/Clogged Pores, Pimples, Oiliness
What did you like about the product? Lightweight, Hydrating, Visible Results
Rated 5 out of 5 stars
2 months ago
My skin feels much more hydrated!
This hydrating creme has left my skin feeling more hydrated than the other products I have used in the past. It's easy to apply and meter out consistently with the pump head. I will be going back for more.
Was this helpful?
KL
Kelly L.
Reviewing
Balancing + Brightening Gel Cream
I recommend this product
What is your skin type? Combination
What are your skin challenges? Whiteheads, Blackheads/Clogged Pores, Pimples, Oiliness, Redness
What did you like about the product? Lightweight, Hydrating
Rated 5 out of 5 stars
2 months ago
Love the gel cream!
This was a great product. I like having skincare products that feel lightweight on my skin and this product was lightweight, moisturizing, and didn’t give me any negative effects on my skin because my skin is pretty sensitive. Also love that it doesn’t have a super strong smell/scent to it. Nice to apply on my face and dries nicely, doesn’t feel sticky or heavy.
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Clinically tested formulas that specifically target and kill the bacteria behind acne, leaving your skin’s beneficial microbiome balanced and restored.