Soothe + Repair Duo
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($62.98 value)
A pair for head-to-toe eczema care: Made with the patented TPZ-01™ enzyme that targets and kills eczema-associated Staph aureus bacteria, our Precision Healing Spray delivers instant and long-lasting relief in a a convenient format that reaches everywhere: face, body, and hard-to-reach areas like back and scalp. Seal in moisture with our Eczema Therapy Cream, which deeply hydrates, repairs the skin barrier, and calms the itch and irritation of eczema.
2-piece Soothe + Repair Duo includes:
Precision Healing Spray 100 mL
Eczema Therapy Cream 200 mL
Free shipping on US orders over $50
Details
Dermatologist Approved
NEA Accepted
EWG Verified®
Safe for Eye Area
Certified Microbiome Friendly
Hypoallergenic
Fragrance Free
Steroid FreeIngredients
How To Use
ECZEMA THERAPY CREAM
This deeply hydrating moisturizer is designed to work in parallel with the Precision Healing Spray to repair the skin barrier. Made with 1% colloidal oatmeal and ceramides, this pH-balanced formula relieves the itch of eczema and supports an optimal pH level for a healthy microbiome.
ECZEMA THERAPY CREAM
This deeply hydrating moisturizer is designed to work in parallel with the Precision Healing Spray to repair the skin barrier. Made with 1% colloidal oatmeal and ceramides, this pH-balanced formula relieves the itch of eczema and supports an optimal pH level for a healthy microbiome.
PRECISION HEALING SPRAY
This easy-to-use spray provides immediate & long-term relief for flare-ups in eczema-prone skin. Made with soothing allantoin and our patented TPZ-01™ enzyme to target and kill eczema-associated Staph aureus bacteria, this convenient spray can be applied to face, body, and hard-to-reach areas whenever irritated skin needs quick calming.
PRECISION HEALING SPRAY
This easy-to-use spray provides immediate & long-term relief for flare-ups in eczema-prone skin. Made with soothing allantoin and our patented TPZ-01™ enzyme to target and kill eczema-associated Staph aureus bacteria, this convenient spray can be applied to face, body, and hard-to-reach areas whenever irritated skin needs quick calming.
Real People, Real Results
I LOVE that I can use it on my child repeatedly, for as long as needed…I didn’t have to be concerned about how long she was using it, like I do with topical steroids, and the fact that IT WORKED made both of us feel better.
KIM
I knew I had a staph problem on my skin…I noticed improvements after the first couple of uses and within a few weeks the flaking is now very minimal. I’m pretty mind blown…10/10 can’t recommend this enough.
DARCI
My 6-year old has struggled with eczema since he was a baby…To say the results were incredible is an understatement. Within just a couple of weeks, his red, itchy skin completely returned to normal.
CHRISTA
I had this angry red patch on my hand for about 3 months. The doctors prescribed me antibiotics, steroid creams, etc. and nothing worked. I ordered Hypothesis as a last ditch effort and was shocked by the results…My patch was cleared up in a week and a half.
SOPHIA
I have tried everything on the market & I had lost hope. I ran into an Instagram profile of a young woman…I was her results and decided to try this brand. Initial reaction, I loved that it relieved the itching…in no time, it cleared up my flare.
HELEN
Within 1 to 2 days my inflammation is way down, and in less than a week it is almost gone…It really has worked better than anything that I have tried.
ERIN
I love the texture of the product. It soothes my skin and applies very easily…can put it on right before bed or right before applying makeup. My redness and flakiness have improved and feels so much better
JESSICA
Where has this been my whole life? This formula is incredible and truly helped my eczema skin so much. It also helped me to realize that staph aureus was definitely playing a role in my flares…
BRYANA
If Hypothesis didn’t exist, I would have thrown in the towel and let urgent care shoot me up with steroids after 3.5 years of battling TSW…My skin felt immense relief after using the Eczema Therapy Cream
CHELSEA
Y’all please get this!! I’ve been having eczema flares on my hands and arm for about 3 years now and no product has worked…Hypothesis has been a game changer. I’m less flakey, not that irritated when I put on long sleeves, and minimal itching.
TAHJ
It definitely has been a god send to finally have something that helps me to manage my eczema.
JANE
I love how smoothly it goes on and that it is easy to apply on the most sensitive of skin. The improvements in my skin were noticeable after just a few uses. I have added this as a permanent product in my eczema rotation!
BRYANA
Precision Healing Spray
Soothes flare-ups + calms eczema-prone skin
RESULTS
100%
100% of participants saw immediate improvement in skin barrier function that lasted all day*
97%
experienced instant improvement in hydration**
95%
agreed the spray is non-irritating and gentle on skin**
*Based on a clinical trial of 33 adults with damaged skin barriers.
**Based on a 7-day clinical study of 34 adults with dry skin.
Eczema Therapy Cream
Hydrates dry skin + restores the skin barrier
RESULTS
96%
said it nourished and improved dry skin*
91%
saw improved hydration for 24 hours after a single use*
100%
of participants saw immediate improvement in skin barrier function that lasted all day**
*Based on a 7-day clinical study of 34 adults with dry skin.
**Based on a clinical trial of 33 adults with damaged skin barriers.
Precision Healing Spray
Soothes flare-ups + calms eczema-prone skin
RESULTS
100%
100% of participants saw immediate improvement in skin barrier function that lasted all day*
97%
experienced instant improvement in hydration**
95%
agreed the spray is non-irritating and gentle on skin**
*Based on a clinical trial of 33 adults with damaged skin barriers.
**Based on a 7-day clinical study of 34 adults with dry skin.
Eczema Therapy Cream
Hydrates dry skin + restores the skin barrier
RESULTS
96%
said it nourished and improved dry skin*
91%
saw improved hydration for 24 hours after a single use*
100%
of participants saw immediate improvement in skin barrier function that lasted all day**
*Based on a 7-day clinical study of 34 adults with dry skin.
**Based on a clinical trial of 33 adults with damaged skin barriers.
Smart Science, By Design
 WITH TPZ-01™ |
COLLOIDAL OATMEAL |
BLEACH BATHS |
STEROID CREAMS |
PRESCRIPTION DRUGS |
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| Treats eczema symptoms |  |
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| Targets eczema-associated S. aureus | |
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| Preserves the skin’s beneficial microbiome | |
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| Patented technology | |
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| No side effects | |
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FAQS
How is this different from other eczema treatments?
Studies show that people with eczema have much higher levels of a bacteria called Staphylococcus aureus on their skin, particularly during flare-ups. Once on the skin, Staphylococcus aureus—also known as Staph, Staph aureus, or S. aureus—can secrete toxins that damage the skin barrier, increase itching, and activate the immune system. The more Staph aureus on skin, the more severe the eczema symptoms—yet standard eczema treatments like moisturizers and steroid creams do not address this underlying imbalance in the eczema skin microbiome.
At Hypothesis, we’re using biotechnology to develop clinically validated skincare that tackles the eczema microbiome head on. Our patented TPZ-01™ precision enzyme targets and kills eczema-associated Staph aureus bacteria while preserving the rest of your skin’s helpful microbiome, helping to reestablish a healthy, balanced microbiome that breaks the cycle of itching, skin barrier damage, and flare-ups.
Do Hypothesis products contain steroids or fragrance?
All Hypothesis products are both steroid-free and fragrance-free. We avoid known irritants in our formulas and use rigorously screened, cutting-edge ingredients with proven track records of both gentleness and efficacy. Our clinically tested formulas are dermatologist-approved, accepted by the National Eczema Association (NEA), EWG Verified™ for Eczema, certified Microbiome Friendly by MyMicrobiome for both infants and adults with eczema, safe for use in the delicate eye area, and hypoallergenic.
Where can I apply Hypothesis products?
The Precision Healing Spray and Eczema Therapy Cream can all be applied anywhere externally on your face or body where you’re experiencing eczema symptoms, including eyelids. All formulas are safe for use around the eyes, dermatologist approved, and accepted by the National Eczema Association (NEA). We recommend applying liberally to itchy, irritated, or dry skin, or anywhere you typically have eczema flare-ups.
How do I use Hypothesis products in my daily routine?
Our Precision Healing Spray with TPZ-01™ is a convenient spray format designed for quick application to hard-to-reach areas or on-the-go use throughout the day. It can be used as a standalone soothing spray, or used in conjunction with our Eczema Precision Hydrogel for a double dose of the TPZ-01™ enzyme. Our Eczema Therapy Cream is a moisturizer designed to work in tandem with the TPZ-01™ enzyme, and can be used after the Precision Healing Spray or Eczema Precision Hydrogel to seal in additional moisture. Apply the Eczema Therapy Cream any time your skin needs immediate hydration or skin barrier repair.
How long does it take to see results?
In clinical studies of the Precision Healing Spray, users experienced instant relief of dry, cracked skin immediately after use and 97% saw improved hydration within 30 minutes. Most users saw additional improvement in flare-ups and irritation within a week, with best results after 2–4 weeks of twice-daily use.In clinical studies, the Eczema Therapy Cream immediately hydrates and strengthens the skin barrier with benefits that last all day.
Reviews
- NRNaiya R.ReviewingECZEMA THERAPY CREAMI recommend this productWhat are your skin challenges? Eczema, Redness, Itchiness, Skin thickening, DrynessWhat is your primary area of concern? Arms, ScalpWhat did you like about the product? Soothing relief, Redness reduction, Fast absorbingRated 5 out of 5 stars8 months agoEczema journey
I loved the cream it was awesome and total game changer. Definitely helped with itching and soothing my skin. Texture is improved so much and skin looks so much healthier
- NWNatalie W.ReviewingECZEMA THERAPY CREAMI recommend this productWhat are your skin challenges? Psoriasis, Redness, Skin thickeningWhat is your primary area of concern? Legs, ArmsWhat did you like about the product? Hydrating, Gentle formula, Fast absorbing, VersatileRated 5 out of 5 stars8 months agoMoisturized the dry patches on my skin
I really loved this cream. It's unscented and calms the dry patches that my psoriasis creates. I used it once a day on my whole body and another targeted on the dry spots where I also applied the spray. I have used it up and would love to use more!
- AEAriane E.ReviewingECZEMA THERAPY CREAMI recommend this productWhat are your skin challenges? Eczema, Itchiness, DrynessWhat is your primary area of concern? Face, Legs, TrunkWhat did you like about the product? Hydrating, Everyday use, Gentle formula, Fast absorbingRated 5 out of 5 stars8 months agoGentle enough for toddler skin!
We loved the cream for everything. I found that I needed less of the product over time as the dryness improved immediately and a little went a long way to keeping the skin hydrated.
- OXOlivia X.ReviewingECZEMA THERAPY CREAMI recommend this productWhat are your skin challenges? Redness, Psoriasis, Texture, HyperpigmentationWhat is your primary area of concern? FaceWhat did you like about the product? Visible results, Soothing relief, Redness reduction, Fast absorbing, HydratingRated 5 out of 5 stars5 minutes agoLightweight and Helpful
I used this alongside the hydrogel which was so nice for my really dry and oil prone skin. I am usually oily on my t zone and then have large dry patches due to psoriasis. I feel like my skin coloration really healed and my forehead looks mostly the same color now instead of really large red patches that were burning to the touch.
- SNSophia N.Verified BuyerReviewingPRECISION HEALING SPRAYI recommend this productWhat are your skin challenges? Eczema, Redness, Itchiness, Dryness, TextureWhat is your primary area of concern? Hands, Legs, Arms, TrunkWhat did you like about the product? Visible results, Soothing relief, Itch relief, Barrier repair, Everyday useRated 5 out of 5 stars6 months agoMagic in a Bottle
I had this angry red patch on my hand for about 3 months. The doctors prescribed me antibiotics, steroid creams, etc. and nothing worked. I developed these patches all over my body, and the doctors kept insisting that steroid creams were the best/only way to heal my eczema. I ordered Hypothesis immediately as a last ditch effort and was shocked by the results. After using the gel, spray, and cream on my hand, my patch was cleared up in a week and a half. The spot is almost completely gone and my skin is so close to feeling like it used to. After using my hand as a test patch and having no reaction, I’ve started using this all over my body and am still amazed by the results! Couldn’t recommend this more. (Before and After Pictures for Proof!!)
Clinically tested, next-generation formulas that treat the bacteria behind flare-ups to visibly transform skin.
