Acne Essentials Duo
Bundle and Save ($74.98 value)
A simple two-step routine to exfoliate, cleanse skin, and target acne bacteria at the source. Our Daily Acne Cleanser dissolves excess oil and prevents new acne blemishes, while our groundbreaking Acne Precision Serum specifically targets acne-causing C. acnes bacteria thanks to the patented CUT-02™ enzyme. These two essentials for acne-prone skin are designed to work together, and are clinically proven to reduce acne symptoms like redness, tenderness, and discoloration—all without harsh side effects.
2-Piece Acne Essentials Duo includes:
- Acne Precision Serum 50mL
- Daily Acne Cleanser 180mL
Free shipping on US orders over $50
Benefits
Dermatologist Approved
Hypoallergenic
Non-comedogenic
Safe for Eye AreaNo Added
Ingredients
How To Use
OTHER KEY INGREDIENTS
Salicylic Acid
This FDA-approved treatment for acne penetrates deep into pores to control breakouts and helps prevent new acne from forming.
Centella Asiatica
Rich in antioxidants, centella helps to calm irritation and strengthen the skin’s naturally protective barrier.
Tea Tree Oil
Derived from the tea tree plant, this ingredient features antioxidant, antibacterial, and anti-inflammatory properties to purify and help calm inflamed skin.
Aloe
The anti-inflammatory extract from the aloe plant helps soothe irritated skin and reduce visible redness.
OTHER KEY INGREDIENTS
Salicylic Acid
This FDA-approved treatment for acne penetrates deep into pores to control breakouts and helps prevent new acne from forming.
Centella Asiatica
Rich in antioxidants, centella helps to calm irritation and strengthen the skin’s naturally protective barrier.
Tea Tree Oil
Derived from the tea tree plant, this ingredient features antioxidant, antibacterial, and anti-inflammatory properties to purify and help calm inflamed skin.
Aloe
The anti-inflammatory extract from the aloe plant helps soothe irritated skin and reduce visible redness.
MEET CUT-02™
99.9% of C. acnes bacteria killed within 1 hour without harming beneficial bacteria*
In a breakthrough for acne care, our patented CUT-02™ enzyme strategically targets and kills acne-causing C. acnes bacteria, leaving the rest of the skin’s beneficial bacteria unharmed. Unlike traditional acne treatments like antibiotics or benzoyl peroxide that destroy all skin microbes, good and bad, the CUT-02™ enzyme's targeted approach means clearer skin, fewer side effects like irritation and redness, and a rapid return to a healthy, balanced microbiome.
*Based on in vitro data of CUT-02™ enzyme
MEET CUT-02™
99.9% of C. acnes bacteria killed within 1 hour without harming beneficial bacteria*
In a breakthrough for acne care, our patented CUT-02™ enzyme strategically targets and kills acne-causing C. acnes bacteria, leaving the rest of the skin’s beneficial bacteria unharmed. Unlike traditional acne treatments like antibiotics or benzoyl peroxide that destroy all skin microbes, good and bad, the CUT-02™ enzyme's targeted approach means clearer skin, fewer side effects like irritation and redness, and a rapid return to a healthy, balanced microbiome.
*Based on in vitro data of CUT-02™ enzyme
Real People, Real Results
Clears breakouts + targets acne-causing bacteria
RESULTS
99.9%
of C. acnes bacteria killed within 1 hour without harming beneficial bacteria*
93%
of people saw improvement in acne symptoms after 2 weeks**
89%
said their skin had less redness**
95%
said it was non-irritating**
*Based on in vitro data of CUT-02™ enzyme
**Based on an 8-week clinical trial of 19 adults with very mild to severe acne
Exfoliates + clears clogged pores
RESULTS
100%
saw reduced acne symptoms within 2 weeks of use*
100%
saw reduced skin oiliness after 4 weeks of use*
91%
reported cleaner pores after 4 weeks of use*
91%
said the cleanser is gentle enough to use twice a day*
*Based on a clinical trial of 32 adults with mild to severe acne (sebumetry measurements)
Clears breakouts + targets acne-causing bacteria
RESULTS
99.9%
of C. acnes bacteria killed within 1 hour without harming beneficial bacteria*
93%
of people saw improvement in acne symptoms after 2 weeks**
89%
said their skin had less redness**
95%
said it was non-irritating**
*Based on in vitro data of CUT-02™ enzyme
**Based on an 8-week clinical trial of 19 adults with very mild to severe acne
Exfoliates + clears clogged pores
RESULTS
100%
saw reduced acne symptoms within 2 weeks of use*
100%
saw reduced skin oiliness after 4 weeks of use*
91%
reported cleaner pores after 4 weeks of use*
91%
said the cleanser is gentle enough to use twice a day*
*Based on a clinical trial of 32 adults with mild to severe acne (sebumetry measurements)
Smart Science, By Design
 with CUT-02™ |
Benzoyl Peroxide | Antibiotics | Accutane | |
|---|---|---|---|---|
| Specifically targets acne bacteria |  |
 |
|
|
| Supports the microbiome | |
|
|
|
| Low risk of skin irritation | |
Dryness, peeling, redness | Irritation + rashes | Severe dryness |
| No other side effects | |
Possible benzene exposure |
Antibiotic resistance |
Significant potential side effects |
| Safe for long-term use | |
Limited by irritation | |
|
FAQS
How is hypothesis™ acne care different from other acne treatments?
Acne treatments like benzoyl peroxide and antibiotics kill bacteria broadly—including the good bacteria your skin needs—and can be harsh on the skin, causing dryness, redness, and irritation. Our patented CUT-02™ precision enzyme is different: it targets only acne-causing C. acnes bacteria while preserving the rest of your skin’s helpful microbiome. The result is effective acne care that's gentle enough for daily use without the harsh side effects that make conventional treatments hard to stick with, and a healthier, more balanced microbiome.
Do hypothesis™ acne products contain fragrance?
Our acne products contain no added fragrances. You may notice that the tea tree oil in our Daily Acne Cleanser formula has a mild herbal aroma. This functional ingredient has antioxidant, antibacterial, and anti-inflammatory properties to purify and help calm inflamed skin. For our Acne Precision Serum containing the CUT-02™ enzyme, you may notice a faint natural aroma from our active and therapeutic ingredients. We choose not to add unnecessary ingredients to mask our formulas’ natural aromas.
Where can I apply the Acne Essentials Duo?
Our Daily Acne Cleanser and Acne Precision Serum can be applied anywhere on your face or body where you’re experiencing breakouts. As with all our products, our acne formulas are safe for use around the eyes, dermatologist approved, and rigorously clinically tested for safety and efficacy. We recommend applying liberally to irritated, acne-prone skin, or anywhere you typically have acne blemishes.
How do I use hypothesis™ acne products in my daily routine?
Start with one application daily: in the evening, cleanse skin with the Daily Acne Cleanser, then apply the Acne Precision Serum. Once the Acne Precision Serum has fully absorbed into the skin, apply a moisturizer as needed and leave on overnight. Increase to twice daily application (morning and evening) if well-tolerated. Apply Precision Microdart Blemish Patches as needed to clean, dry skin to address early, under-the-surface pimples.
Our acne products are designed to work synergistically with one another, and the Daily Acne Cleanser is specifically formulated to be compatible with our precision acne products with the CUT-02™ enzyme. If you use other serums or treatments in your regimen, we recommend applying them after the Daily Acne Cleanser and before the Acne Precision Serum.
Note: As products with salicylic acid can increase your skin’s sun sensitivity, use an SPF during the day.
How long does it take to see results with the Acne Essentials Duo?
You should typically start to see improvements within one to two weeks, with the most substantial results building over the full 8 weeks — particularly during weeks 4–8. In our 8-week clinical trial, 71% of participants noticed improvement after one week and 93% saw a reduction in acne within two weeks. Over the full 8 weeks, participants reported reduced oiliness, redness, and comedones, as well as more even skin tone.
As with many acne treatments, consistent daily use is key — it takes time for the microbiome to rebalance and inflammation to calm.
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- MMagdalaneReviewingAcne Precision SerumI recommend this productWhat is your skin type? CombinationWhat are your skin challenges? Hyperpigmentation, Blackheads/Clogged PoresWhat did you like about the product? Gentle formula, Lightweight, Microbiome friendly, Easy to applyRated 5 out of 5 stars1 month agoResults in 2 weeks
Used it with their cleanser and my skin was completely clear in two weeks. Genuinely nothing like it.
- AEAriane E.ReviewingDaily Acne CleanserI recommend this productWhat is your skin type? Combination, SensitiveWhat are your skin challenges? Blackheads/Clogged Pores, PimplesWhat did you like about the product? Everyday use, Skin feels cleansed, Easy to rinse off, Gentle formulaRated 4 out of 5 stars1 month agoGood for sensitive skin and adult acne
I really liked the smell of this cleanser. The gentleness for everyday use and the improvement of my acne along my jawline after a breakout. It did not prevent my acne breakouts however, I did enjoy trying this product.
- IRIzek R.ReviewingDaily Acne CleanserI recommend this productWhat is your skin type? Oily, Acne-proneWhat are your skin challenges? Whiteheads, Blackheads/Clogged Pores, Pimples, Oiliness, RednessWhat did you like about the product? Everyday use, Skin feels cleansed, Easy to rinse off, LightweightRated 4 out of 5 stars2 months agoEasy to use
Easy to use and visible results. Made significant improvements in skin texture.
- IRIzek R.ReviewingAcne Precision SerumI recommend this productWhat is your skin type? OilyWhat are your skin challenges? Whiteheads, Blackheads/Clogged Pores, Pimples, Oiliness, RednessWhat did you like about the product? Everyday use, Hydrating, Lightweight, Easy to applyRated 4 out of 5 stars2 months agoEasy to use
Easy to use and visible results that made a change in skin. Happy
- MTMikel T.ReviewingAcne Precision SerumI recommend this productWhat is your skin type? Oily, Dry, SensitiveWhat are your skin challenges? Whiteheads, Blackheads/Clogged Pores, Pimples, Oiliness, RednessWhat did you like about the product? Everyday use, Redness reduction, Hydrating, Easy to applyRated 5 out of 5 stars2 months agoClears it all up!
From having a face full of acne to instantly having a clear face has been so life changing. I have used so many different acne cleansers, but this one helped clear up my acne, especially with me having sensitive skin!
Clinically tested formulas that specifically target and kill the bacteria behind acne, leaving your skin’s beneficial microbiome balanced and restored.
