Eczema Precision Hydrogel
Relieves irritation + itching from eczema
Made with our patented TPZ-01™ enzyme, this lightweight hydrogel is the first eczema treatment to address the skin’s microbiome imbalance head on, targeting eczema-associated Staph aureus bacteria to break the cycle of damage and irritation so skin can finally heal.
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Benefits
Dermatologist Approved
Safe for Eye Area
NEA Accepted
Hypoallergenic
EWG Verified®
Steroid Free
Certified Microbiome Friendly
Fragrance FreeIngredients
How To Use
KEY INGREDIENTS
Colloidal Oatmeal
This oat-derived skin protectant soothes itching and calms irritation from eczema.
Pro-Vitamin B5 + Sorbitol
Two potent moisture magnets that hydrate, comfort, and help replenish the skin barrier.
Amino Acid Complex
These antioxidant-rich essential amino acids help support skin elasticity and improve moisture retention.
KEY INGREDIENTS
Colloidal Oatmeal
This oat-derived skin protectant soothes itching and calms irritation from eczema.
Pro-Vitamin B5 + Sorbitol
Two potent moisture magnets that hydrate, comfort, and help replenish the skin barrier.
Amino Acid Complex
These antioxidant-rich essential amino acids help support skin elasticity and improve moisture retention.
MEET TPZ-01™
99.99% of S. aureus bacteria killed within 5 minutes*
In a breakthrough for eczema care, our patented TPZ-01™ enzyme strategically zeroes in on eczema-associated Staph aureus bacteria, leaving the rest of the microbiome balanced for a stronger, more resilient skin barrier.
*Based on in vitro data of TPZ-01™ enzyme
MEET TPZ-01™
99.99% of Staph aureus bacteria killed within 5 minutes*
In a breakthrough for eczema care, our patented TPZ-01™ enzyme strategically zeroes in on eczema-associated Staph aureus bacteria, leaving the rest of the microbiome balanced for a stronger, more resilient skin barrier.
*Based on in vitro data of TPZ-01™ enzyme
Real People, Real Results
I LOVE that I can use it on my child repeatedly, for as long as needed…I didn’t have to be concerned about how long she was using it, like I do with topical steroids, and the fact that IT WORKED made both of us feel better.
KIM
I knew I had a staph problem on my skin…I noticed improvements after the first couple of uses and within a few weeks the flaking is now very minimal. I’m pretty mind blown…10/10 can’t recommend this enough.
DARCI
My 6-year old has struggled with eczema since he was a baby…To say the results were incredible is an understatement. Within just a couple of weeks, his red, itchy skin completely returned to normal.
CHRISTA
I had this angry red patch on my hand for about 3 months. The doctors prescribed me antibiotics, steroid creams, etc. and nothing worked. I ordered Hypothesis as a last ditch effort and was shocked by the results…My patch was cleared up in a week and a half.
SOPHIA
I have tried everything on the market & I had lost hope. I ran into an Instagram profile of a young woman…I was her results and decided to try this brand. Initial reaction, I loved that it relieved the itching…in no time, it cleared up my flare.
HELEN
Within 1 to 2 days my inflammation is way down, and in less than a week it is almost gone…It really has worked better than anything that I have tried.
ERIN
I love the texture of the product. It soothes my skin and applies very easily…can put it on right before bed or right before applying makeup. My redness and flakiness have improved and feels so much better
JESSICA
Where has this been my whole life? This formula is incredible and truly helped my eczema skin so much. It also helped me to realize that staph aureus was definitely playing a role in my flares…
BRYANA
If Hypothesis didn’t exist, I would have thrown in the towel and let urgent care shoot me up with steroids after 3.5 years of battling TSW…My skin felt immense relief after using the Eczema Therapy Cream
CHELSEA
Y’all please get this!! I’ve been having eczema flares on my hands and arm for about 3 years now and no product has worked…Hypothesis has been a game changer. I’m less flakey, not that irritated when I put on long sleeves, and minimal itching.
TAHJ
The Hypothesis gel provides me with instant itch relief, and my highly sensitive skin has no reaction to the formula.
JULIA
It definitely has been a god send to finally have something that helps me to manage my eczema.
JANE
Clinically Proven Eczema Relief Within 2 Weeks
2.5 x
more effective than a standard eczema treatment*
85 %
reduction in eczema-associated Staph aureus bacteria on the skin*
100 %
of participants saw reduced eczema symptoms within 2 weeks*
*Based on a 2-week clinical trial of 24 adults with moderate to severe eczema comparing Hypothesis Eczema Precision Hydrogel to a product containing over-the-counter levels of colloidal oatmeal.
Smart Science, By Design
 WITH TPZ-01™ |
COLLOIDAL OATMEAL |
BLEACH BATHS |
STEROID CREAMS |
PRESCRIPTION DRUGS |
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| Treats eczema symptoms |  |
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| Targets eczema-associated S. aureus | |
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| Preserves the skin’s beneficial microbiome | |
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| Patented technology | |
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| No side effects | |
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FAQS
How is this different from other eczema treatments?
Studies show that people with eczema have much higher levels of a bacteria called Staphylococcus aureus on their skin, particularly during flare-ups. Once on the skin, Staphylococcus aureus—also known as Staph, Staph aureus, or S. aureus—can secrete toxins that damage the skin barrier, increase itching, and activate the immune system. The more Staph aureus on skin, the more severe the eczema symptoms—yet standard eczema treatments like moisturizers and steroid creams do not address this underlying imbalance in the eczema skin microbiome.
At Hypothesis, we’re using the science of biotechnology to develop clinically validated skincare that tackles the eczema microbiome head on. Our patented TPZ-01™ precision enzyme targets and kills eczema-associated Staph aureus bacteria while preserving the rest of your skin’s helpful microbiome, helping to reestablish a healthy, balanced microbiome that breaks the cycle of itching, skin barrier damage, and flare-ups.
Does the Eczema Precision Hydrogel contain steroids?
All Hypothesis products are both steroid-free and fragrance-free. We avoid known irritants in our formulas and use rigorously screened, cutting-edge ingredients with proven track records of both gentleness and efficacy. Our clinically tested formulas are dermatologist-approved, accepted by the National Eczema Association (NEA), EWG Verified®, certified Microbiome Friendly by MyMicrobiome for both infants and adults with eczema, safe for use in the delicate eye area, and hypoallergenic.
Does the Eczema Precision Hydrogel contain fragrance?
The Eczema Precision Hydrogel is fragrance-free. We avoid known irritants in our formulas and use rigorously screened, cutting-edge ingredients with proven track records of both gentleness and efficacy. You may notice a mild, naturally-occurring scent from the amino acid methionine. Methionine is an antioxidant that helps maintain the stability of our patented TPZ-01™ enzyme while protecting the skin from free radicals and supporting the skin barrier. Rather than covering this natural scent with potentially irritating synthetic fragrances or chemical masking agents, we choose to keep our formula as streamlined as possible to minimize irritation. Methionine's scent is completely normal and should quickly fade as the formula absorbs into your skin.
Where can I apply the Eczema Precision Hydrogel?
The Eczema Precision Hydrogel can be applied anywhere externally on your face or body where you’re experiencing eczema symptoms, including eyelids. As with all our products, this formula is safe for use around the eyes, dermatologist approved, and accepted by the National Eczema Association (NEA). We recommend applying liberally to itchy, irritated, or dry skin, or anywhere you typically have eczema flare-ups.
As with all new skincare products, we recommend doing a patch test before first use, especially if you have very sensitive skin or known allergies. Apply a small amount to an area like the inside of your wrist or behind your ear, wait 24 hours, and check for any reaction before applying to larger areas or your face.
How do I use Hypothesis products in my daily routine?
We recommend using our Eczema Precision Hydrogel with our patented TPZ-01™ precision enzyme at least twice a day (morning and night), but more often if needed for additional soothing. Our Precision Healing Spray with TPZ-01™ is a convenient spray format designed for quick application to hard-to-reach areas or on-the-go use throughout the day. It can be used as a standalone soothing spray, or used in conjunction with our Eczema Precision Hydrogel for a double dose of the TPZ-01™ enzyme. Our Eczema Therapy Cream is a moisturizer designed to work in tandem with the TPZ-01™ enzyme, and can be used after the Precision Healing Spray or Eczema Precision Hydrogel to seal in additional moisture. Apply the Eczema Therapy Cream any time your skin needs immediate hydration or skin barrier repair.
How long does it take to see results?
In clinical studies of the Eczema Precision Hydrogel, most users saw initial improvement in their eczema symptoms within a week, with best results after 2–4 weeks of twice-daily use.
Is the Eczema Precision Hydrogel safe for babies and children?
Yes, all of our hypoallergenic, dermatologist-approved formulas are extensively tested by independent certifying organizations to meet the highest standards for safety and gentleness on sensitive skin. Our formulas are steroid-free and fragrance-free, have received the National Eczema Association (NEA) Seal of Acceptance, and are EWG Verified® for meeting stringent standards for safety and sustainability. Our products are also certified Microbiome Friendly by MyMicrobiome for both infants and adults.
Reviews
Clinically tested, next-generation formulas that treat the bacteria behind flare-ups to visibly transform skin.
