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PRECISION HEALING SPRAY
4.4
Rated 4.4 out of 5 stars
4.4
#size_standard size 200ml
4.6
Rated 4.6 out of 5 stars
4.6
#size_standard size 80ml
4.4
Rated 4.4 out of 5 stars
4.4
ECZEMA PRECISION KIT
4.7
Rated 4.7 out of 5 stars
4.7

ECZEMA PRECISION KIT

A set of travel-sized skin-soothing eczema essentials

4.7
Rated 4.7 out of 5 stars
4.7

Your complete eczema care routine in travel-friendly sizes. This duo targets flare-ups at their source, with our patented TPZ-01™ enzyme that specifically eliminates Staph aureus bacteria while restoring your skin's natural balance. Our Eczema Precision Hydrogel delivers lasting relief, while our Eczema Therapy Cream replenishes your skin barrier and locks in moisture. Together, they soothe itching and reduce irritation for real relief.

2-piece Eczema Precision Kit includes:
Eczema Precision Hydrogel 30 mL
Eczema Therapy Cream 30 mL

Details

Backed by independent testing and some of the most rigorous certifications in skincare, our formulas represent a new standard in safe, effective eczema care.

Dermatologist Approved
Safe for Eye Area
NEA Accepted
Hypoallergenic
EWG Verified®
Steroid Free
Certified Microbiome Friendly
Fragrance Free
Ingredients

TPZ-01™ Enzyme
Our patented TPZ-01™ enzyme selectively targets and kills 99.99% of eczema-associated Staph aureus bacteria within 5 minutes while preserving beneficial microorganisms.

Colloidal Oatmeal
The key calming component in chamomile, this anti-inflammatory ingredient helps to reduce redness.

3 Essential Ceramides
This oat-derived skin protectant soothes itching and calms irritation from eczema.

Advanced Moisture Complex
(Hyaluronic Acid, Sodium PCA, Urea, Glycerin)

Four potent moisture attractors provide immediate hydration for dry, irritated skin.

Full ingredient list

Eczema Precision Hydrogel
Active Ingredient: 0.01% Colloidal Oatmeal
Inactive Ingredients:
Water/Aqua/Eau, Sorbitol, Arginine HCl, Hydroxyethylpiperazine Ethane Sulfonic Acid, Panthenol, Sodium Chloride, Hydroxypropyl Methylcellulose, Methionine, Calcium Chloride, Methylparaben, Sodium Hydroxide, Acetyl Cysteine, sr-(Staphylococcus sp. Polypeptide-1 Dipeptide-81 Streptococcus Suis Phage Polypeptide-1 Dipeptide-19 Hexapeptide-40), Hydrochloric Acid

Eczema Therapy Cream
Active Ingredient: 1% Colloidal Oatmeal
Inactive Ingredients:
Water/Aqua/Eau, Glycerin, Caprylic/Capric Triglyceride, Cetyl Alcohol, Bis-Diglyceryl Polyacyladipate-2, Jojoba Esters, Polyglyceryl-2 Stearate, Butyrospermum Parkii (Shea) Butter, Bisabolol, Zingiber Officinale (Ginger) Extract, Ceramide NP, Ceramide AP, Ceramide EOP, Phytosphingosine, Cholesterol, Sodium PCA, Urea, Trehalose, Sodium Hyaluronate, Hexylene Glycol, Polyquaternium-51, Triacetin, Caprylyl Glycol, Sodium Lauroyl Lactylate, Tocopherol, Tocopheryl Acetate, Dimethicone, Ammonium Acryloyldimethyltaurate/VP Copolymer, Hydroxyacetophenone, Glyceryl Stearate, Stearyl Alcohol, Carbomer, Xanthan Gum, 1,2-Hexanediol, Citric Acid, Sodium Hydroxide, Tetrasodium Glutamate Diacetate, Ethylhexylglycerin

How To Use

Shake and apply Eczema Precision Hydrogel to eczema-prone skin at least twice daily (morning and evening) or as often as desired. Let absorb into the skin for 5 minutes before layering on other skincare. Use as a standalone treatment, or follow with Eczema Therapy Cream as part of a comprehensive eczema regimen. Apply Eczema Therapy Cream to body and face as often as needed to lock in moisture, soothe itch, and calm dry, eczema-prone skin. 

ECZEMA THERAPY CREAM

This deeply hydrating moisturizer is designed to work in parallel with the Eczema Precision Hydrogel to repair the skin barrier. Made with 1% colloidal oatmeal and ceramides, this pH-balanced formula relieves the itch of eczema and supports an optimal pH level for a healthy microbiome.

ECZEMA PRECISION HYDROGEL

Made with our patented TPZ-01™ enzyme, this lightweight hydrogel is the first eczema treatment to address the skin’s microbiome imbalance head on, targeting and killing eczema-associated Staph aureus bacteria to break the cycle of damage and irritation so skin can finally heal.

ECZEMA THERAPY CREAM

This deeply hydrating moisturizer is designed to work in parallel with the Eczema Precision Hydrogel to repair the skin barrier. Made with 1% colloidal oatmeal and ceramides, this pH-balanced formula relieves the itch of eczema and supports an optimal pH level for a healthy microbiome.

ECZEMA PRECISION HYDROGEL

Made with our patented TPZ-01™ enzyme, this lightweight hydrogel is the first eczema treatment to address the skin’s microbiome imbalance head on, targeting and killing eczema-associated Staph aureus bacteria to break the cycle of damage and irritation so skin can finally heal.

Eczema Precision Hydrogel

Relieves irritation + itching from eczema

RESULTS

2.5x

more effective than a standard eczema treatment*

85%

reduction in eczema-associated Staph aureus bacteria on the skin*

100%

of participants saw reduced eczema symptoms within 2 weeks*

*Based on a 2-week clinical trial of 24 adults with moderate to severe eczema comparing Hypothesis Eczema Precision Hydrogel to a product containing over-the-counter levels of colloidal oatmeal.

Eczema Therapy Cream

Hydrates dry skin + restores the skin barrier

RESULTS

96%

said it nourished and improved dry skin*

91%

saw improved hydration for 24 hours after a single use*

100%

of participants saw immediate improvement in skin barrier function that lasted all day**

*Based on a 7-day clinical study of 34 adults with dry skin.
**Based on a clinical trial of 33 adults with damaged skin barriers.

Jessica M.

I love the texture of the hydrogel. It soothes my skin and applies very easily…can put it on right before bed or right before applying makeup. My redness and flakiness have improved and feels so much better.

Kim W.

Not gonna lie, I stole some of this cream I got for my daughter for myself!…Helps relieve the tightness and soothes the cracks both she and I get. It feels rich and thick—we both really enjoy using it!

Smart Science, By Design

FAQS

How is this different from other eczema treatments?

Studies show that people with eczema have much higher levels of a bacteria called Staphylococcus aureus on their skin, particularly during flare-ups.  Once on the skin, Staphylococcus aureus—also known as Staph, Staph aureus, or S. aureus—can secrete toxins that damage the skin barrier, increase itching, and activate the immune system. The more Staph aureus on skin, the more severe the eczema symptoms—yet standard eczema treatments like moisturizers and steroid creams do not address this underlying imbalance in the eczema skin microbiome.

 At Hypothesis, we’re using the science of biotechnology to develop clinically validated skincare that tackles the eczema microbiome head on. Our patented TPZ-01™ precision enzyme targets and kills eczema-associated Staph aureus bacteria while preserving the rest of your skin’s helpful microbiome, helping to reestablish a healthy, balanced microbiome that breaks the cycle of itching, skin barrier damage, and flare-ups.

Does the Eczema Precision Hydrogel contain steroids or fragrance? 

All Hypothesis products are both steroid-free and fragrance-free. We avoid known irritants in our formulas and use rigorously screened, cutting-edge ingredients with proven track records of both gentleness and efficacy. Our clinically tested formulas are dermatologist-approved, accepted by the National Eczema Association (NEA), EWG Verified™, certified Microbiome Friendly by MyMicrobiome for both infants and adults with eczema, safe for use in the delicate eye area, and hypoallergenic.

Where can I apply Hypothesis products?

The Eczema Precision Hydrogel and Eczema Therapy Cream can be applied anywhere externally on your face or body where you’re experiencing eczema symptoms, including eyelids. As with all our products, this formula is safe for use around the eyes, dermatologist approved, and accepted by the National Eczema Association (NEA). We recommend applying liberally to itchy, irritated, or dry skin, or anywhere you typically have eczema flare-ups.

As with all new skincare products, we recommend doing a patch test before first use, especially if you have very sensitive skin or known allergies. Apply a small amount to an area like the inside of your wrist or behind your ear, wait 24 hours, and check for any reaction before applying to larger areas or your face.

How do I use Hypothesis products in my daily routine?

We recommend using our Eczema Precision Hydrogel with our patented TPZ-01™ precision enzyme at least twice a day (morning and night), but more often if needed for additional soothing. Our Precision Healing Spray with TPZ-01™ is a convenient spray format designed for quick application to hard-to-reach areas or on-the-go use throughout the day. It can be used as a standalone soothing spray, or used in conjunction with our Eczema Precision Hydrogel for a double dose of the TPZ-01™ enzyme. Our Eczema Therapy Cream is a moisturizer designed to work in tandem with the TPZ-01™ enzyme, and can be used after the Precision Healing Spray or Eczema Precision Hydrogel to seal in additional moisture. Apply the Eczema Therapy Cream any time your skin needs immediate hydration or skin barrier repair.

How long does it take to see results?

In clinical studies of the Eczema Precision Hydrogel, most users saw initial improvement in their eczema symptoms within a week, with best results after 2–4 weeks of twice-daily use. The Eczema Therapy Cream immediately hydrates and strengthens the skin barrier with benefits that last all day.

Is the Eczema Precision Hydrogel safe for babies and children?

Yes, all of our hypoallergenic, dermatologist-approved formulas are extensively tested by independent certifying organizations to meet the highest standards for safety and gentleness on sensitive skin. Our formulas are steroid-free and fragrance-free, have received the National Eczema Association (NEA) Seal of Acceptance, and are EWG Verified™ for meeting stringent standards for safety and sustainability. Our products are also certified Microbiome Friendly by MyMicrobiome for both infants and adults.

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100%would recommend this product
4.7
Rated 4.7 out of 5 stars
Based on 17 reviews
Total 5 star reviews: 12 Total 4 star reviews: 5 Total 3 star reviews: 0 Total 2 star reviews: 0 Total 1 star reviews: 0
17 reviews
  • DW
    Darci W.
    I recommend this product
    What are your skin challenges? Eczema, Redness, Itchiness, Skin thickening, Dryness
    What is your primary area of concern? Face, Hands, Legs, Arms
    What did you like about the product? Visible results, Soothing relief, Itch relief, Redness reduction
    Rated 5 out of 5 stars
    1 month ago
    It worked.

    I started using the Precision Hydrogel mid flare on my face, I know I had a staph problem on my skin because I had previously had a skin scraping from my dermatologist to confirm it was staph. After a round of antibiotics I was still having issues with the bacteria causing another flare. I had redness, a burning sensation when applying cream, pretty intense flaking with an all over puffiness/swollen complexion. I noticed improvements after the first couple of uses and within a few weeks the flaking is now very minimal, I have no more redness or burning and as a by product my skin is less puffy. I'm pretty mind blown. Make sure you wait the 5 minutes before applying any other creams after - which is the only annoying part of using this product but I really can't get over how well this worked on my skin. I will be using this as a regular part of my routine. 10/10 can't recommend this enough.

    The therapy cream works well and is gentle and moisturizing. Good basic cream to have for adding moisture to the skin.

  • AD
    Alexia D.
    I recommend this product
    What are your skin challenges? Eczema, Redness, Itchiness, Dryness
    What is your primary area of concern? Face
    What did you like about the product? Visible results, Soothing relief, Itch relief, Redness reduction, Fast absorbing
    Rated 5 out of 5 stars
    1 month ago
    My new favorite eczema product

    The hypothesis products are fantastic! I used the eczema precision hydrogel to treat a spot of eczema on my face, and within a week, it was basically gone, after being resistant to improvement with other over the counter lotions for several months. The precision hydrogel also, surprisingly, eliminated a chlorine rash from my daughter’s legs. The rash looked similar to eczema to me, and so I wondered if it would help. It did! She’d had the rash for over a week, not improving with lotion or steroid creams. And again, after a couple of days of treatment with the precision hydrogel, her skin was clear. I heartily recommend this lotion to my friends and family, and it has become an instant staple in our household.

    I've been very impressed with the eczema therapy cream. As a person with dry, sensitive skin, I've had a lot of negative reactions to lotions -- even those that are listed as "sensitive" or "hypoallergenic". With this one, I didn't have any of that sensitivity or irritation pop up. Instead, it felt like a light, soothing lotion with a surprisingly deep and long-lasting hydrating effect. I also appreciate the lack of perfume in this, since that can also be a trigger for my skin to react. The eczema therapy cream has a mild oatmeal scent that is pleasant and not distracting. I'm looking forward to using this with our family's dry hands in the winter!

  • LJ
    Lisa J.
    I recommend this product
    What are your skin challenges? Eczema, Redness, Itchiness, Dryness
    What is your primary area of concern? Face, Neck, Legs, Arms
    What did you like about the product? Redness reduction, Microbiome friendly, Everyday use, Gentle formula
    Rated 4 out of 5 stars
    1 month ago
    Reduced topical steroid use to almost zero

    The pictures don't do it justice for my daughter's eczema flare(s). But the hydrogel/relief spray has helped to shorten her flares cycles and prevent it progressing and deteriorating rapidly. We have been able to move away from the potent steroid creams and oils from 2 to 3 times a day on the whole body to less once weekly to specific areas. The hot spots and patches are still apparent with hypopenmentation and dryness. But the redness and rentless itching/scratching is much improved.

    The therapy cream is a very good moisturizer, no smell, light, thick yet not greasey at all.

  • AE
    Ariane E.
    I recommend this product
    What are your skin challenges? Eczema, Itchiness, Dryness
    What is your primary area of concern? Face, Legs, Trunk
    What did you like about the product? Visible results, Soothing relief, Hydrating, Gentle formula, Fast absorbing
    Rated 5 out of 5 stars
    1 month ago
    Smooth and hydrated

    From patchy rough spots to smooth all over. The eczema on my son’s back can appear sometimes quickly after a sweaty nap or hot day of play outside, but these last few weeks he has had no new breakouts and his skin is soft and smooth from head to toe.

    We loved the cream for everything. I found that I needed less of the product over time as the dryness improved immediately and a little went a long way to keeping the skin hydrated.

  • RY
    Richmond Y.
    Verified Reviewer
    I recommend this product
    What are your skin challenges? Eczema, Itchiness
    What is your primary area of concern? Arms
    What did you like about the product? Visible results, Soothing relief, Itch relief, Fast absorbing, Barrier repair
    Rated 5 out of 5 stars
    6 days ago
    Stops itching instantly

    I’ve been itching really badly on the inside of my elbows, and this is the only product that stopped the itching immediately after I applied it. It doesn’t irritate my skin at all, and the science behind it is no joke. I don’t even need to use it every day because it helps my skin so much. I just apply it when it starts itching. By far the best product I’ve tried! I don’t itch as often anymore, and my cuts are healing.”