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Precision Clarifying Spray

Targets C. acnes bacteria + soothes breakout prone skin

4.8
Rated 4.8 out of 5 stars
4.8
Unlike conventional sprays that wipe out all bacteria, this precision spray for breakout-prone skin uses the patented CUT-02™ enzyme to selectively target breakout-causing bacteria in hard-to-reach areas without disrupting the skin’s beneficial microbiome. Clinically proven to soothe & restore the barrier, relieving irritation in breakout-prone skin.
Benefits
  • Specifically targets breakout-causing C. acnes bacteria
  • Preserves the skin's beneficial bacteria and strengthens the barrier
  • Soothes and relieves irritation in breakout-prone skin
  • Visibly reduces redness
  • Provides weightless moisture and skin barrier support
  • Restores the skin's protective microbiome
  • Reaches hard-to-reach areas including back and chest
Dermatologist Approved
Hypoallergenic
Non-comedogenic
Safe for Sensitive Skin
Safe for Eye Area
No Added
  • Fragrance
  • Oils
  • Silicones
  • Phthalates
  • Dyes
  • Drying alcohols
  • Benzoyl peroxide
Ingredients

CUT-02™ Enzyme
A patented first-of-its-kind precision enzyme that selectively targets breakout-causing C. acnes bacteria while preserving the skin's beneficial microbiome.

Allantoin
A multifunctional skin protectant that soothes and relieves irritation in breakout-prone skin.

Aloe
The anti-inflammatory extract from the aloe plant helps soothe irritated skin and reduce visible redness.

Betaine
Naturally derived from beets, betaine moisturizes, restores the barrier, and protects against environmental stressors to skin.

Full Ingredient List
Water/Aqua/Eau, Betaine, Aloe Barbadensis Leaf Juice, Allantoin, sr-(Caudoviricetes Polypeptide-1 Depeptide-81 Cutibacterium Acnes Polypeptide-1 Pentapeptide-124 Dipeptide-19 Hexapeptide-40), Caprylhydroxamic Acid, 1,2-Hexanediol, Propanediol, Hydroxyethylpiperazine Ethane Sulfonic Acid, Sodium Chloride, Arginine HCl, Methionine, Sodium Hydroxide, Hydrochloric Acid

How To Use

Apply to irritated, acne-prone skin on face or body as often as needed throughout the day. 

OTHER KEY INGREDIENTS

Allantoin

A multifunctional skin protectant that soothes and relieves irritation in breakout-prone skin.

Aloe

The anti-inflammatory extract from the aloe plant helps soothe irritated skin and reduce visible redness.

Betaine

Naturally derived from beets, betaine moisturizes, restores the barrier, and protects against environmental stressors to skin.

MEET CUT-02™

99.9% of C. acnes bacteria killed within 1 hour without harming beneficial bacteria*

In a breakthrough for acne care, our patented CUT-02™ enzyme strategically targets and kills acne-causing C. acnes bacteria, leaving the rest of the skin's beneficial bacteria unharmed. Unlike traditional sprays that destroy all skin microbes, good and bad, the CUT-02™ enzyme's targeted approach means clearer skin, fewer side effects like irritation and redness, and a rapid return to a healthy, balanced microbiome.

*Based on in vitro data of CUT-02™ enzyme

OTHER KEY INGREDIENTS

Allantoin

A multifunctional skin protectant that soothes and relieves irritation in breakout-prone skin.

Aloe

The anti-inflammatory extract from the aloe plant helps soothe irritated skin and reduce visible redness.

Betaine

Naturally derived from beets, betaine moisturizes, restores the barrier, and protects against environmental stressors to skin.

MEET CUT-02™

 99.9% of C. acnes bacteria killed within 1 hour without harming beneficial bacteria*

In a breakthrough for acne care, our patented CUT-02™ enzyme strategically targets and kills acne-causing C. acnes bacteria, leaving the rest of the skin's beneficial bacteria unharmed. Unlike traditional sprays that destroy all skin microbes, good and bad, the CUT-02™ enzyme's targeted approach means clearer skin, fewer side effects like irritation and redness, and a rapid return to a healthy, balanced microbiome.

*Based on in vitro data of CUT-02™ enzyme

Real People, Real Results

Clinically Proven to Soothe + Restore the Barrier

99.9%

of C. acnes bacteria killed within 1 hour without harming beneficial bacteria*

100%

experienced skin barrier regeneration after a single use**

97%

experienced instant hydration**

84%

said it soothed breakouts**

*Based on in vitro data of CUT-02™ enzyme
**Based on a clinical trial of 32 adults with mild to severe acne

Benzoyl Peroxide Antibiotics Accutane
Specifically targets acne bacteria
Supports the microbiome
Low risk of skin irritation Dryness, peeling, redness Irritation + rashes Severe dryness
No other side effects Possible benzene
exposure
Antibiotic
resistance
Significant potential
side effects
Safe for long-term use Limited by irritation
*data on file

FAQS

How is the Precision Clarifying Spray different from hypochlorous acid sprays or other acne sprays?

Most conventional sprays like hypochlorous acid eliminate all bacteria—including the beneficial bacteria your skin needs to stay balanced. The Precision Clarifying Spray is different: its patented CUT-02™ enzyme selectively targets only breakout-causing C. acnes bacteria while preserving your skin's protective microbiome. The result is effective bacterial control that’s gentle enough for daily use without the harsh side effects that make conventional treatments hard to stick with.

Does the Precision Clarifying Spray contain benzoyl peroxide?

All hypothesis™ products, including the Precision Clarifying Spray, are benzoyl peroxide-free and benzene-free. We avoid known irritants in our formulas and use rigorously screened, cutting-edge ingredients with proven track records of both gentleness and efficacy. Our targeted, clinically tested formulas are dermatologist-approved, microbiome-friendly, hypoallergenic, non-comedogenic, and non-irritating to eyes.

Where can I use the Precision Clarifying Spray?

The Precision Clarifying Spray can be applied anywhere on the face or body where you're experiencing breakouts—it’s particularly good for hard-to-reach areas like the back and chest. It's also safe for the eye area, dermatologist approved, and clinically tested for safety and gentleness.

Does the Precision Clarifying Spray contain fragrance?

As with all hypothesis™ products, the Precision Clarifying Spray contains no added fragrances. You may notice a faint natural aroma from our active and therapeutic ingredients. We choose not to add unnecessary ingredients to mask our formulas' natural aromas.

How do I use hypothesis™ acne products in my daily routine?

Start with one application daily: in the evening, cleanse skin with the Daily Acne Cleanser, then apply the Acne Precision Serum. Once the Acne Precision Serum has fully absorbed into the skin, apply Balancing + Brightening Gel Cream and leave on overnight. Increase to twice daily application (morning and evening) if well-tolerated. Apply Precision Clarifying Spray as needed throughout the day to instantly calm skin and keep C. acnes bacteria in check. Apply Precision Microdart Blemish Patches as needed to clean, dry skin to address early, under-the-surface pimples.


Note: The Daily Acne Cleanser and Acne Precision Serum contain salicylic acid. As products with salicylic acid can increase your skin’s sun sensitivity, use an SPF during the day.

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100%would recommend this product
4.8
Rated 4.8 out of 5 stars
Based on 6 reviews
6 reviews
  • KL
    Kelly L.
    I recommend this product
    Rated 5 out of 5 stars
    4 days ago
    Love the spray

    I really liked this product. As someone who gets acne flare ups throughout the month I’m always looking for products to treat my skin. This spray product was great, I love it as a spray option because it’s convenient, I brought it with me to use after the gym, and I love not having to rub a product in with my hands. I am also very sensitive to smells so I like that there’s not a strong scent to it.

  • BM
    Brandi M.
    I recommend this product
    Rated 5 out of 5 stars
    6 days ago
    Gentle & effective!

    I've been using the Hypothesis Precision Clarifying Spray in my daily skincare routine and I love it! It's very gentle on my skin but has made a noticeable improvement in my acne. I like how the spray comes out in a fine mist. It's easy to target certain areas where I'm having breakouts. The spray is soothing and doesn't irritate my skin. It absorbs quickly and easily. It works perfectly with my other Hypothesis products. Highly recommend!

  • BD
    Brie D. V.
    I recommend this product
    Rated 5 out of 5 stars
    Yesterday
    Lightweight, effective, and easy to apply!

    This product is easy to apply in just the right amount. It applies super lightweight so I can use it in the morning and evening.

  • MK
    Megan K.
    I recommend this product
    Rated 4 out of 5 stars
    5 days ago
    Clarifying spray

    I've been loving the Hypothesis Precision Clarifying Spray for those moments when my skin needs a quick refresh throughout the day. The mist feels incredibly lightweight and soothing, making it easy to use on both my face and body without leaving behind any sticky residue. What I appreciate most is how convenient it is. Whether I've just finished a workout, spent time outdoors, or simply want to freshen up my skin between classes, this spray helps my skin feel clean and balanced. The fine mist is gentle enough for sensitive, acne-prone skin and doesn't interfere with my makeup or skincare routine. I've also noticed that my skin looks less irritated after using it consistently, especially during periods when I'm more prone to breakouts. The compact bottle makes it easy to keep in my bag, so I can use it anytime, anywhere. If you're looking for a simple addition to your skincare routine that helps refresh acne-prone skin and supports a clearer-looking complexion, this spray is definitely worth trying.

  • OB
    Ozzie B.
    I recommend this product
    Rated 5 out of 5 stars
    6 days ago
    First spray that works for my skin

    My skin is dry and acne prone, with relatively frequent irritation from treating the acne. If your skin is like mine, nothing works exactly right. Retinols and strong acids help acne, but can actually make you so irritated that you get more acne from your barrier being damaged. Lots of soothing products are really helpful for the redness and barrier elements, but as soon as I start using them regularly enough to see a real difference, I get little colorless bumps and weird texture. Both of these things suck because maintaining consistency is what gets rid of acne. This spray is the first one for acne that is light, soothing, effective, and portable enough to work into my routine. I have used this as part of a larger routine at night but it’s also great to bring to the gym with only moisturizer and face wash. Very easy to spray on my face, leave for one minute, and continue getting ready.