THE GIFT OF REAL RELIEF.
Limited edition bundles are here! Save up to 25% on eczema essentials with our new bundles—and when you spend $75 or more, receive 2 free gel bead ice packs for cooling therapeutic relief.
Offer valid through 12/5 at 11:59pm PST or while supplies last. Receive a free gift on orders $75+ after discounts, before taxes and shipping. One free gift per order.
groundbreaking formulas that fundamentally rethink how we treat eczema.
“Effective long-term eczema care depends on more than just treating inflammation and itch—it means restoring and preserving a healthy skin microbiome.”
— Peter Lio, MD
Board-Certified Dermatologist
2.5x
more effective than a standard eczema treatment*
99.99%
of Staph aureus bacteria killed within 5 minutes**
*Based on a 2-week clinical trial of 24 adults with moderate to severe eczema comparing Hypothesis Eczema Precision Hydrogel to a product containing over-the-counter levels of colloidal oatmeal.
**Based on in vitro data of TPZ-01™enzyme
MEET
TPZ-O1™
Our Proprietary Enzyme
In a breakthrough for eczema care, our patented TPZ-01™ enzyme zeroes in on eczema-associated Staph aureus bacteria and eliminates them.
What you’ll see? Real daily relief that breaks the cycle of flare-ups and irritation so skin can finally heal.
MEET TPZ-O1™
Our Proprietary Enzyme
In a breakthrough for eczema care, our patented TPZ-01™ enzyme zeroes in on eczema-associated Staph aureus bacteria and eliminates them.
What you’ll see? Real daily relief that breaks the cycle of flare-ups and irritation so skin can finally heal.
2.5x
more effective than a standard eczema treatment*
99.99%
of Staph aureus bacteria killed within 5 minutes**
*Based on a 2-week clinical trial of 24 adults with moderate to severe eczema comparing Hypothesis Eczema Precision Hydrogel to a product containing over-the-counter levels of colloidal oatmeal.
**Based on in vitro data of TPZ-01™enzyme
ECZEMA + THE MICROBIOME
In a healthy skin microbiome, microorganisms live in balance and support skin health—but an eczema microbiome looks dramatically different.
Staph aureus bacteria on the skin drive eczema symptoms
The harmful bacteria Staph aureus can make up to 90% of the eczema microbiome, triggering flare-ups, itching, and skin barrier damage.
TPZ-01™ enzyme kills Staph aureus + preserves beneficial microbes
Unlike conventional eczema treatments, the TPZ-01™ enzyme addresses this root cause of eczema symptoms while preserving the skin’s protective microbiome.
Eczema Precision Hydrogel
Relieves irritation + itching from eczema
RESULTS
2.5x
more effective than a standard eczema treatment*
85%
reduction in eczema-associated Staph aureus bacteria on the skin*
100%
of participants saw reduced eczema symptoms within 2 weeks*
*Based on a 2-week clinical trial of 24 adults with moderate to severe eczema comparing Hypothesis Eczema Precision Hydrogel to a product containing over-the-counter levels of colloidal oatmeal.
Eczema Therapy Cream
Hydrates dry skin + restores the skin barrier
RESULTS
96%
said it nourished and improved dry skin*
91%
saw improved hydration for 24 hours after a single use*
100%
of participants saw immediate improvement in skin barrier function that lasted all day**
*Based on a 7-day clinical study of 34 adults with dry skin.
**Based on a clinical trial of 33 adults with damaged skin barriers.
Precision Healing Spray
Soothes flare-ups + calms eczema-prone skin
RESULTS
100%
100% of participants saw immediate improvement in skin barrier function that lasted all day*
97%
experienced instant improvement in hydration**
95%
agreed the spray is non-irritating and gentle on skin**
*Based on a clinical trial of 33 adults with damaged skin barriers.
**Based on a 7-day clinical study of 34 adults with dry skin.
Eczema Precision Hydrogel
Relieves irritation + itching from eczema
RESULTS
2.5x
more effective than a standard eczema treatment*
85%
reduction in eczema-associated Staph aureus bacteria on the skin*
100%
of participants saw reduced eczema symptoms within 2 weeks*
*Based on a 2-week clinical trial of 24 adults with moderate to severe eczema comparing Hypothesis Eczema Precision Hydrogel to a product containing over-the-counter levels of colloidal oatmeal.
Eczema Therapy Cream
Hydrates dry skin + restores the skin barrier
RESULTS
96%
said it nourished and improved dry skin*
91%
saw improved hydration for 24 hours after a single use*
100%
of participants saw immediate improvement in skin barrier function that lasted all day**
*Based on a 7-day clinical study of 34 adults with dry skin.
**Based on a clinical trial of 33 adults with damaged skin barriers.
Precision Healing Spray
Soothes flare-ups + calms eczema-prone skin
RESULTS
100%
100% of participants saw immediate improvement in skin barrier function that lasted all day*
97%
experienced instant improvement in hydration**
95%
agreed the spray is non-irritating and gentle on skin**
*Based on a clinical trial of 33 adults with damaged skin barriers.
**Based on a 7-day clinical study of 34 adults with dry skin.
Tested. Certified. Safe.
Our cutting-edge precision formulas have been rigorously tested and clinically validated for safety and efficacy.
Accepted by the National Eczema Association (NEA)
Certified Microbiome Friendly for Infants and Adults
EWG Verified®
Leaping Bunny Certified
Soothing in Action
See how our precision enzyme technology visibly calms and transforms eczema-prone skin.
Within 1–2 days my inflammation is way down, and in less than a week it is almost gone...It really has worked better than anything that I have tried.
ERIN
Not gonna lie, I stole some of this product I got for my daughter for myself!…Helps relieve the tightness and soothes the cracks both she and I get. It feels rich and thick—we both really enjoy using it!
KIM
I love the texture of the product. It soothes my skin and applies very easily…can put it on right before bed or right before applying makeup. My redness and flakiness have improved and feels so much better.
JESSICA
Backed by Dermatologists
