Acne Precision Serum
Clears breakouts + targets acne-causing bacteria
This cutting-edge gel-serum specifically targets acne-causing C. acnes bacteria with our patented CUT-02™ enzyme, clearing breakouts and preventing future acne without disrupting your skin’s beneficial microbiome. Our rigorously tested formula is clinically proven to reduce acne symptoms like redness, tenderness, and discoloration—all without the harsh side effects of traditional acne treatments.
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Benefits
Dermatologist Approved
Hypoallergenic
Non-comedogenic
Safe for Eye AreaNo Added
Ingredients
How To Use
KEY INGREDIENTS
0.5% Salicylic Acid
This FDA-approved treatment for acne penetrates deep into pores to control breakouts and helps prevent new acne from forming.
Pro-Vitamin B5
This moisture-attracting ingredient reduces visible redness, adds weightless hydration, and helps replenish the skin barrier.
Centella Asiatica
Rich in antioxidants, centella helps to calm irritation and strengthen the skin’s naturally protective barrier.
KEY INGREDIENTS
0.5% Salicylic Acid
This FDA-approved treatment for acne penetrates deep into pores to control breakouts and helps prevent new acne from forming.
Pro-Vitamin B5
This moisture-attracting ingredient reduces visible redness, adds weightless hydration, and helps replenish the skin barrier.
Centella Asiatica
Rich in antioxidants, centella helps to calm irritation and strengthen the skin’s naturally protective barrier.
Betaine
Naturally derived from beets, betaine provides lightweight hydration & protects against future irritation.
MEET CUT-02™
99.9% of C. acnes bacteria killed within 1 hour without harming beneficial bacteria*
In a breakthrough for acne care, our patented CUT-02™ enzyme strategically targets and kills acne-causing C. acnes bacteria, leaving the rest of the skin’s beneficial bacteria unharmed. Unlike traditional acne treatments like antibiotics or benzoyl peroxide that destroy all skin microbes, good and bad, the CUT-02™ enzyme's targeted approach means clearer skin, fewer side effects like irritation and redness, and a rapid return to a healthy, balanced microbiome.
*Based on in vitro data of CUT-02™ enzyme
MEET CUT-02™
99.9% of C. acnes bacteria killed within 1 hour without harming beneficial bacteria*
In a breakthrough for acne care, our patented CUT-02™ enzyme strategically targets and kills acne-causing C. acnes bacteria, leaving the rest of the skin’s beneficial bacteria unharmed. Unlike traditional acne treatments like antibiotics or benzoyl peroxide that destroy all skin microbes, good and bad, the CUT-02™ enzyme's targeted approach means clearer skin, fewer side effects like irritation and redness, and a rapid return to a healthy, balanced microbiome.
*Based on in vitro data of CUT-02™ enzyme
Real People, Real Results
Clinically Proven to Reduce Acne Without Irritation in 2 Weeks
99.9 %
of C. acnes bacteria killed within 1 hour without harming beneficial bacteria*
93 %
of people saw improvement in acne symptoms after 2 weeks**
89 %
said their skin had less redness**
95 %
said it was non-irritating**
*Based on in vitro data of CUT-02™ enzyme
**Based on an 8-week clinical trial of 19 adults with very mild to severe acne
Smart Science, By Design
 with CUT-02™ |
Benzoyl Peroxide | Antibiotics | Accutane | |
|---|---|---|---|---|
| Specifically targets acne bacteria |  |
 |
|
|
| Supports the microbiome | |
|
|
|
| Low risk of skin irritation | |
Dryness, peeling, redness | Irritation + rashes | Severe dryness |
| No other side effects | |
Possible benzene exposure |
Antibiotic resistance |
Significant potential side effects |
| Safe for long-term use | |
Limited by irritation | |
|
FAQS
How is the Acne Precision Serum different from other acne treatments?
Acne treatments like benzoyl peroxide and antibiotics kill bacteria broadly—including the good bacteria your skin needs—and can be harsh on the skin, causing dryness, redness, and irritation. The patented CUT-02™ enzyme in our Acne Precision Serum is different: it targets only acne-causing C. acnes bacteria while preserving the rest of your skin’s helpful microbiome. The result is effective acne care that's gentle enough for daily use without the harsh side effects that make conventional treatments hard to stick with, and a healthier, more balanced microbiome.
Does the Acne Precision Serum contain benzoyl peroxide?
All hypothesis™ products, including the Acne Precision Serum, are benzoyl peroxide-free and benzene-free. We avoid known irritants in our formulas and use rigorously screened, cutting-edge ingredients with proven track records of both gentleness and efficacy. Our targeted, clinically tested formulas are dermatologist-approved, microbiome-friendly, hypoallergenic, non-comedogenic, and non-irritating to eyes.
How long does it take to see results?
You should typically start to see improvements within one to two weeks, with the most substantial results building over the full 8 weeks — particularly during weeks 4–8. In our 8-week clinical trial, 71% of participants noticed improvement after one week and 93% saw a reduction in acne within two weeks. Over the full 8 weeks, participants reported reduced oiliness, redness, and comedones, as well as more even skin tone.
As with many acne treatments, consistent daily use is key — it takes time for the microbiome to rebalance and inflammation to calm.
Where can I apply the Acne Precision Serum?
The Acne Precision Serum can be applied anywhere on your face or body where you’re experiencing breakouts. As with all our products, our acne formulas are safe for use around the eyes, dermatologist approved, and rigorously clinically tested for safety and efficacy. We recommend applying liberally to irritated, acne-prone skin, or anywhere you typically have acne blemishes.
How do I use hypothesis™ acne products in my daily routine?
Start with one application daily: in the evening, cleanse skin with the Daily Acne Cleanser, then apply the Acne Precision Serum. Once the Acne Precision Serum has fully absorbed into the skin, apply a moisturizer as needed and leave on overnight. Increase to twice daily application (morning and evening) if well-tolerated. Apply Precision Microdart Blemish Patches as needed to clean, dry skin to address early, under-the-surface pimples.
Our acne products are designed to work synergistically with one another, and the Daily Acne Cleanser is specifically formulated to be compatible with our precision acne products with the CUT-02™ enzyme. If you use other serums or treatments in your regimen, we recommend applying them after the Daily Acne Cleanser and before the Acne Precision Serum.
Note: As products with salicylic acid can increase your skin’s sun sensitivity, use an SPF during the day.
Does the Acne Precision Serum contain fragrance?
As with all our acne products, the Acne Precision Serum contains no added fragrances. You may notice a faint natural aroma from our active and therapeutic ingredients. We choose not to add unnecessary ingredients to mask our formulas’ natural aromas.
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Clinically tested formulas that specifically target and kill the bacteria behind acne, leaving your skin’s beneficial microbiome balanced and restored.
