3-Step Precision Acne Routine
Cleanse, treat + restore for clearer, balanced skin
A complete precision acne routine in three steps: Daily Acne Cleanser dissolves excess oil without stripping, Acne Precision Serum with our patented CUT-02™ enzyme targets acne-causing bacteria, and Balancing + Brightening Gel Cream restores the barrier—all clinically proven to clear breakouts without harsh side effects.
3-Step Precision Acne Routine includes:
- Daily Acne Cleanser 180mL
- Acne Precision Serum 50mL
- Balancing + Brightening Gel Cream 50mL
Use the full 3-Step Precision Acne Routine for at least 30 days. If you're not satisfied with your results, return it within 60 days of purchase for a full refund minus shipping. (Learn More)
Free shipping on US orders over $50
Benefits
Dermatologist Approved
Hypoallergenic
Non-comedogenic
Safe for Eye Area
Safe for Sensitive SkinNo Added
Ingredients
How To Use
ACNE PRECISION SERUM
This cutting-edge gel-serum specifically targets acne-causing C. acnes bacteria with the patented CUT-02™ enzyme, clearing breakouts and preventing future acne without disrupting your skin's beneficial microbiome and without the harsh side effects of conventional acne treatments.
brightening + balancing gel cream
This oil-free, weightless moisturizer hydrates and rebalances the skin barrier while visibly reducing post-acne discoloration and uneven skin tone. Made with hyaluronic acid and niacinamide, it's clinically proven to accelerate skin barrier regeneration while providing long-lasting hydration.
DAILY ACNE CLEANSER
This daily purifying cleanser exfoliates clogged pores and dissolves excess oil, treating acne without drying the skin barrier. Designed to work in parallel with the patented CUT-02™ enzyme, this cleanser is clinically proven to reduce oiliness, acne, and redness.
ACNE PRECISION SERUM
This cutting-edge gel-serum specifically targets acne-causing C. acnes bacteria with the patented CUT-02™ enzyme, clearing breakouts and preventing future acne without disrupting your skin's beneficial microbiome and without the harsh side effects of conventional acne treatments.
brightening + balancing gel cream
This oil-free, weightless moisturizer hydrates and rebalances the skin barrier while visibly reducing post-acne discoloration and uneven skin tone. Made with hyaluronic acid and niacinamide, it's clinically proven to accelerate skin barrier regeneration while providing long-lasting hydration.
DAILY ACNE CLEANSER
This daily purifying cleanser exfoliates clogged pores and dissolves excess oil, treating acne without drying the skin barrier. Designed to work in parallel with the patented CUT-02™ enzyme, this cleanser is clinically proven to reduce oiliness, acne, and redness.
Real People, Real Results
Daily Acne Cleanser
RESULTS
100%
saw reduced acne symptoms within 2 weeks of use*
100%
saw reduced skin oiliness after 4 weeks of use*
91%
reported cleaner pores after 4 weeks of use*
91%
said the cleanser is gentle enough to use twice a day*
*Based on a clinical trial of 32 adults with mild to severe acne
Acne Precision Serum
RESULTS
99.9%
of C. acnes bacteria killed within 1 hour without harming beneficial bacteria*
97%
saw fewer breakouts**
81%
reduction in inflamed pimples**
95%
said it was non-irritating**
*Based on in vitro data of CUT-02™ enzyme
**Based on a clinical trial of 32 adults with mild to severe acne
Balancing + Brightening Gel Cream
Hydrates dry skin + restores the skin barrier
RESULTS
100%
experienced skin barrier regeneration after a single use*
100%
experienced instant hydration*
81%
reported more even skin tone in 4 weeks**
89%
said their skin had less redness in 4 weeks**
*Based on a clinical trial of 31 adults with mild to severe acne
** Based on a clinical trial of 32 adults with mild to severe acne
Daily Acne Cleanser
RESULTS
100%
saw reduced acne symptoms within 2 weeks of use*
100%
saw reduced skin oiliness after 4 weeks of use*
91%
reported cleaner pores after 4 weeks of use*
91%
said the cleanser is gentle enough to use twice a day*
*Based on a clinical trial of 32 adults with mild to severe acne
Acne Precision Serum
RESULTS
99.9%
of C. acnes bacteria killed within 1 hour without harming beneficial bacteria*
97%
saw fewer breakouts**
81%
reduction in inflamed pimples**
95%
said it was non-irritating**
*Based on in vitro data of CUT-02™ enzyme
**Based on a clinical trial of 32 adults with mild to severe acne
Balancing + Brightening Gel Cream
Hydrates dry skin + restores the skin barrier
RESULTS
100%
experienced skin barrier regeneration after a single use*
100%
experienced instant hydration*
81%
reported more even skin tone in 4 weeks**
89%
said their skin had less redness in 4 weeks**
*Based on a clinical trial of 31 adults with mild to severe acne
** Based on a clinical trial of 32 adults with mild to severe acne
Smart Science, By Design
 with CUT-02™ |
Benzoyl Peroxide | Antibiotics | Accutane | |
|---|---|---|---|---|
| Specifically targets acne bacteria |  |
 |
|
|
| Supports the microbiome | |
|
|
|
| Low risk of skin irritation | |
Dryness, peeling, redness | Irritation + rashes | Severe dryness |
| No other side effects | |
Possible benzene exposure |
Antibiotic resistance |
Significant potential side effects |
| Safe for long-term use | |
Limited by irritation | |
|
FAQS
How is this routine different from conventional acne treatments?
Most acne treatments target all bacteria—disrupting your skin's microbiome and causing harsh side effects like dryness and irritation. Our three-step routine is built around the patented CUT-02™ enzyme, which selectively targets only acne-causing C. acnes bacteria while preserving your skin's beneficial microbiome. The result is effective acne care gentle enough for daily use.
How long does it take to see results?
You should typically start to see improvements within one to two weeks, with the most substantial results building over the full 8 weeks. In our clinical trial, 97% of participants reported fewer breakouts and 95% experienced no irritation over 8 weeks of daily use. Consistent daily use is key—it takes time for the microbiome to rebalance and inflammation to calm.
What's included in the 3-Step Precision Acne Routine?
The 3-Step Precision Acne Routine includes Daily Acne Cleanser, Acne Precision Serum, and Balancing + Brightening Gel Cream—everything you need for a complete precision acne care regimen.
Is this routine safe for sensitive skin?
Yes. All three products are dermatologist approved, hypoallergenic, non-comedogenic, and safe for sensitive skin and the eye area. Our precision approach targets only acne-causing bacteria, meaning fewer harsh side effects than conventional treatments.
Note: The Daily Acne Cleanser and Acne Precision Serum contain salicylic acid. As products with salicylic acid can increase your skin’s sun sensitivity, use an SPF during the day.
Does this routine contain fragrance?
None of the products in the 3-Step Precision Acne Routine contain added fragrances. You may notice a faint natural aroma from our active and therapeutic ingredients, particularly the amino acid methionine in the Acne Precision Serum and the tea tree oil in the Daily Acne Cleanser. We choose not to add unnecessary ingredients to mask our formulas' natural aromas.
How do I use hypothesis™ acne products in my daily routine?
Start with one application daily: in the evening, cleanse skin with the Daily Acne Cleanser, then apply the Acne Precision Serum. Once the Acne Precision Serum has fully absorbed into the skin, apply Balancing + Brightening Gel Cream and leave on overnight. Increase to twice daily application (morning and evening) if well-tolerated. Apply Precision Clarifying Spray as needed throughout the day to instantly calm skin and keep C. acnes bacteria in check. Apply Precision Microdart Blemish Patches as needed to clean, dry skin to address early, under-the-surface pimples.
Note: The Daily Acne Cleanser and Acne Precision Serum contain salicylic acid. As products with salicylic acid can increase your skin’s sun sensitivity, use an SPF during the day
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- NMNatsumi M.ReviewingAcne Precision SerumI recommend this productWhat is your skin type? Dry, Combination, SensitiveWhat are your skin challenges? Blackheads/Clogged Pores, Pimples, OilinessWhat did you like about the product? Non-drying, Lightweight, Microbiome friendly, Easy to applyRated 5 out of 5 stars3 months agoGreat product!
Loved this serum! Used as directed after the paired cleanser. I loved that it didn’t leave my face feeling greasy. Super easy to apply and love the gentle yet super effective formula.
- AHAlex H.ReviewingDaily Acne CleanserI recommend this productWhat is your skin type? Combination, Acne-proneWhat are your skin challenges? Blackheads/Clogged Pores, PimplesWhat did you like about the product? Skin feels cleansed, Gentle formula, Lightweight, Non-dryingRated 4 out of 5 stars3 months agoEnjoyable
I liked the cleanser! It made my face feel clean and had a nice smell. I think it soaked in a little bit when I would put it on, so I had to really rub it on my face. I don’t really know if I’ve seen results, but I wasn’t as consistent as I should have been.
- ATAnnie T.ReviewingDaily Acne CleanserI recommend this productWhat is your skin type? Oily, Acne-proneWhat are your skin challenges? Whiteheads, Pimples, RednessWhat did you like about the product? Easy to rinse off, Gentle formula, Redness reductionRated 5 out of 5 stars3 months agoGentle and effective
Easy to use and seems to be effective. Worked in stubborn acne that did not respond to salicylic acid cleansing pads.
- AGAllegra G.ReviewingDaily Acne CleanserI recommend this productWhat is your skin type? Dry, Acne-prone, SensitiveWhat are your skin challenges? Whiteheads, Blackheads/Clogged Pores, Pimples, Hyperpigmentation, RednessWhat did you like about the product? Easy to rinse off, Gentle formulaRated 4 out of 5 stars1 month agoGood product strong smell
This is a great cleanser for acne prone skin, it’s gentle and easy to apply. The only comment i have is there is a strong minty smell to it.
- KWKim W.ReviewingBalancing + Brightening Gel CreamI recommend this productWhat is your skin type? Acne-prone, SensitiveWhat are your skin challenges? Whiteheads, PimplesWhat did you like about the product? Lightweight, HydratingRated 5 out of 5 stars6 days agoLightweight and effective
I am really impressed by this product. It felt more lightweight and slippery, and less creamy, than the daily moisturizer I typically use. But it was so hydrating!! It totally soothed the tight feeling I get after washing my face and was super effective at keeping my dry skin hydrated. Worked all day, didn’t clog my pores, didn’t interfere with my makeup. I also like the dispenser, I only needed a little to apply over my whole face and this dispenser gave me good control over how much I pumped out.
Clinically tested formulas that specifically target and kill the bacteria behind acne, leaving your skin’s beneficial microbiome balanced and restored.
